Pyrrolidine, piperidine, and pyridine alkaloids

Experimental Study on the Thermochemistry of Some Derivatives of Piperidinol

“…Piperidines are nonaromatic nitrogen heterocycles that, due to their applications, have attracted the attention of many fields of research. In fact, the piperidine derivatives are largely present in natural products. , In recent years, due to their biological and potential therapeutics, much attention has been paid toward the developments of an efficient synthesis , and to the employment of these compounds in drug-like molecules with medicinal uses. − …”

“…In fact, the piperidine derivatives are largely present in natural products. 1,2 In recent years, due to their biological and potential therapeutics, much attention has been paid toward the developments of an efficient synthesis 3,4 and to the employment of these compounds in drug-like molecules with medicinal uses. [5][6][7][8] The scientific literature already presents some thermochemical studies of some piperidine derivatives.…”

An Aminocatalyzed Michael Addition/Iron-Mediated Decarboxylative Cyclization Sequence for the Preparation of 2,3,4,6-Tetrasubstituted Pyridines: Scope and Mechanistic Insights

“…Reaction time: 96 h. Purification by flash column chromatography (SiO 2 , gradient: Hex - 9:1 Hex/AcOEt - 8:2 Hex/AcOEt - 7:3 Hex/AcOEt - 1:1 Hex/AcOEt) affords the title compound as a yellow oil (47 mg, 78%) …”

“…The pyridine heterocycle is an aromatic motif found in numerous alkaloids, pharmaceuticals, agrochemicals, chiral ligands, and materials, often present in R&D programs. Therefore, perhaps not surprisingly, synthetic approaches leading to this heteroaromatic nucleus are abundant.…”

Thermolysis of Geminal Diazides: Reagent-Free Synthesis of 3-Hydroxypyridines

“…The intriguing chemical nature of the pyridine heterocycle in combination with its prominence in natural products and pharmaceuticals has inspired chemists to develop new and efficient methodologies toward its synthesis . In particular, 3-hydroxypyridines have recently attracted attention due to their promising biological activity (Figure ).…”