Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice

Obara, Kiyohaya; Ishihara, Masayuki; Ishizuka, Toshiaki; Fujita, Masanori; Ozeki, Yuichi; Maehara, Tadaaki; Saitō, Yoshio; Yura, Hirofumi; Matsui, Takemi; Hattori, Hidemi; Kikuchi, Makoto; Kurita, Akira

doi:10.1016/s0142-9612(03)00220-5

Cited by 287 publications

(180 citation statements)

References 25 publications

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“…Chitosan hydrogel induced wound closure. The addition of FGF-2 to the chitosan hydrogel further accelerated wound closure, a substantial formation of granulation tissue and re-epithelialization only in db/db mice (Obara et al, 2003). Such properties support the use of chitosan as a carrier for growth factors with a gradually controlled release.…”

Section: Hydrogels and Growth Factor Deliverymentioning

confidence: 61%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

439

198

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Abstract:Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethylchitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,Ntrimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

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Section: Hydrogels and Growth Factor Deliverymentioning

confidence: 61%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

439

198

View full text Add to dashboard Cite

show abstract

“…Wound dressings that release NO [38][39][40] on the wound surface, wound dressings containing bFGF 41,42) and a glycosaminoglycan hydrogel film 43) have recently been developed for healing skin lesions. All of these dressings have been shown to enhance healing of a full-thickness excisional wound, but they have not yet been made available as commercial products.…”

Section: Discussionmentioning

confidence: 99%

Effect of Zwitterionic Polymers on Wound Healing

Fujishita

Inaba

Tada

et al. 2008

Biological & Pharmaceutical Bulletin

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The effect of a thin film of a zwitterionic random copolymer composed of carboxybetaine [1-carboxy-N,Ndimethyl-N-(2 -methacryloyloxyethyl)methanaminium inner salt] (CMB) and n-butyl methacrylate (BMA), poly(CMB-r-BMA) (CMB, 30 mol%), on the healing of a full-thickness excisional and incisional wound in hairless rats was examined. The poly(CMB-r-BMA) film significantly enhanced wound closure and complete healing of a full-thickness excisional wound compared with the effect of the poly(n-butyl methacrylate) (PBMA) and the poly(ethylene terephthalate) (PET) films. However, the poly(CMB-r-BMA) film did not enhance healing of a fullthickness incisional wound in hairless rats. The amount of proteins adsorbed and that of neutrophiles adhered onto the poly(CMB-r-BMA) film were significantly smaller than those onto the PBMA and PET films. The results suggested that various cells and growth factors in the wound exudate are utilized effectively by covering an excisional wound with the poly(CMB-r-BMA) film, resulting in acceleration of healing. In addition, the poly(CMB-r-BMA) film significantly enhanced healing of a full-thickness excisional wound in hairless rats compared with the effect of Tegaderm ® as wound dressings. The poly(CMB-r-BMA) film has potential as a new wound dressing.

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“…With increased drug resistance and cytotoxic effect of antiseptics used for wound dressing (Cooper et al, 1991;Greenwood, 1995), the need for a safe and effective dressing also increased. Chitosan hydrogel might be one of the most useful and protective forms which allow contraction of the wound in a suitably moist healing environment, as well as, possess most of the properties of an ideal wound dressing materials (Labrude and Becq, 2003;Obara et al, 2003;Stashak et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Effect of Chitosan Gel on Wound Healing: Experimental Study in Donkeys

Anis¹,

Sharshar²,

Gaber³

et al. 2017

AJVS

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Key words:Chitosan gel, Donkeys, Histopathological changes, Wound healing Chitosan is one of the natural bioactive materials known for its wound healing effect. Healing of equine's wounds are often delayed and complicated. This study aimed to evaluate efficacy of chitosan gel on healing of equine skin-wounds in comparison to povidone-iodine (as control). Six adult male donkeys were used and divided equally into two groups; group A (2x2 cm skin-wound) and group B (4x4 cm skin-wound). Full thickness skin-wounds were created on forearms and shoulders. Wounds at the right side were irrigated using povidone-iodine, while wounds at the left side were dressed using chitosan gel. Clinically, chitosan treated wounds contracted faster than control wounds, and shoulder-wounds contracted faster than that of the forearm. By the end of the experiment all chitosan treated wounds were completely healed with intact epidermis. In contrast, 10.4 % and 13.3 % of wound's area treated with povidone-iodine in group B at the shoulder and the forearm regions, respectively, still unclosed. Grossly, povidoneiodine treated wounds in both regions, were covered with scab in group A, and had an area of granulation tissue in the wound-centers in group B. Chitosan treated wounds, in both groups in both regions, were completely covered with cornified epithelium. Microscopically, the re-epithelialization was uncompleted in povidone-iodine treated wounds in both groups in both regions. In contrary, complete epidermal layer was observed in wounds treated with chitosan in both groups in both regions. Finally, chitosan gel may be better than povidone-iodine in healing of equine skin wounds.

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Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice

Cited by 287 publications

References 25 publications

Chitosan as a starting material for wound healing applications

Chitosan as a starting material for wound healing applications

Effect of Zwitterionic Polymers on Wound Healing

Effect of Chitosan Gel on Wound Healing: Experimental Study in Donkeys

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