Photoaging: a Review of Current Literature

Huang, Amy; Chien, Anna L.

doi:10.1007/s13671-020-00288-0

Cited by 54 publications

(65 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Twenty-eight members of the human MMP family have been isolated and identified [36]. They can be divided into five subgroups: (1) Collagenase (MMP-1, MMP-8, and MMP-13) recognizes the substrate through the hemophilia protein-like domain and degrades collagen; (2) Gelatinase (MMP-2 and MMP-9) can digest a variety of ECMs, such as type I collagen and type IV collagen; (3) Stromelysins (MMP-3, MMP-10, and MMP-11) are similar to collagenase, but cannot cut type I collagen; (4) Stromelysins (MMP-7 and MMP-26) lack hemophilin-like domains and degrade type IV collagen but not type I collagen; (5) The membrane-type MMPs (MMP-14, MMP-15, and MMP-16) break down type I collagen. MMPs in mice are similar to humans, and studies also found the high expression and significant role of MMPs in mouse skin [37].…”

Section: Matrix Metalloproteinases (Mmps)mentioning

confidence: 99%

“…Among them, photoaging is the most crucial factor causing skin aging damage. Skin photoaging is caused by long-term exposure to ultraviolet (UV) [ 3 ] and manifests as rough, dry, and sagging skin, deeper skin wrinkles, excessive skin pigmentation, or angiotelectasis [ 4 ], even leading to various benign or malignant tumors, such as solar keratosis, squamous cell carcinoma, and malignant melanoma [ 5 ]. UV activates or inhibits various signal pathways in the dermis and epidermis, leading to a decrease in the content of the extracellular matrix (ECM) and causing uneven structure or even skin collapse [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Boosting the Photoaged Skin: The Potential Role of Dietary Components

et al. 2021

View full text Add to dashboard Cite

Skin photoaging is mainly induced by ultraviolet (UV) irradiation and its manifestations include dry skin, coarse wrinkle, irregular pigmentation, and loss of skin elasticity. Dietary supplementation of nutraceuticals with therapeutic and preventive effects against skin photoaging has recently received increasing attention. This article aims to review the research progress in the cellular and molecular mechanisms of UV-induced skin photoaging. Subsequently, the beneficial effects of dietary components on skin photoaging are discussed. The photoaging process and the underlying mechanisms are complex. Matrix metalloproteinases, transforming growth factors, skin adipose tissue, inflammation, oxidative stress, nuclear and mitochondrial DNA, telomeres, microRNA, advanced glycation end products, the hypothalamic–pituitary–adrenal axis, and transient receptor potential cation channel V are key regulators that drive the photoaging-associated changes in skin. Meanwhile, mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging. The major mechanisms of these dietary components to alleviate skin photoaging include the maintenance of skin moisture and extracellular matrix content, regulation of specific signaling pathways involved in the synthesis and degradation of the extracellular matrix, and antioxidant capacity. Taken together, the ingestion of food-derived functional components could be an attractive strategy to prevent skin photoaging damage.

show abstract

Section: Matrix Metalloproteinases (Mmps)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Boosting the Photoaged Skin: The Potential Role of Dietary Components

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The process of photoaging also depends on skin phototype, ethnicity, and sex. In terms of pathogenesis, ultraviolet radiation is the worst causative factor in photoaging by inciting oxidative damage and pro-inflammatory pathways leading to structural changes in the skin [ 3 ]. For this reason, the prevention and treatment of these risks are important and interesting.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Anti-Photoaging Effects on UVA-Irradiated Human Fibroblasts of Rosmarinic Acid Enriched Extract Prepared from Thunbergia laurifolia Leaves

Pattananandecha

Apichai

Julsrigival

et al. 2021

Plants

View full text Add to dashboard Cite

The current study investigated the inhibiting effect on reactive oxygen species (ROS), reactive nitrogen species (RNS), and matrix metalloproteinase-1 (MMP-1) production in a cell-based study of standardized rosmarinic acid enriched extract (SRAEE) prepared from Thunbergia laurifolia leaves. HPLC chromatogram revealed that rosmarinic acid is a major component in prepared SRAEE, followed by caffeic acid. SRAEE exhibited antioxidant activity both in vitro and cell-based studies. SRAEE showed scavenging effects on nitric oxide and superoxide anion and inhibition effects on lipid peroxidation in vitro. SRAEE also inhibited ROS and MMP-1 production in normal human dermal fibroblast cells induced by H2O2 and UVA, respectively, without exerted cytotoxicity. Additionally, collagen degradation was protected by SRAEE induced by UVA. Nitric oxide and inducible nitric oxide synthase (iNOS) productions were also inhibited by SRAEE in RAW264.7 mouse macrophage cells induced by combined lipopolysaccharide (LPS)-interferon-γ (IFN-γ). The results indicated that SRAEE is a potential candidate as a natural pharmaceutical active ingredient for cosmeceutical product application.

show abstract

“…Although many scientists have tried their best to slow, halt, or reverse the destruction of the ozone layer, such as reducing the emission of chlorofluorocarbons, this recovery process requires several years or even decades ( Krutmann and Berneburg, 2021 ). Therefore, we should focus on the use of the existing resources for treating or preventing the damage induced by UV radiation ( Sambandan and Ratner, 2011 ; Huang and Chien, 2020 ). Photoaging is one of the main causes of damage from long-term UV radiation and is very hard to avoid in daily life ( Poon et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-Photoaging and Anti-Inflammatory Effects of Ginsenoside Rk3 During Exposure to UV Irradiation

et al. 2021

View full text Add to dashboard Cite

Ginseng is a widely cultivated perennial plant in China and Korea. Ginsenoside Rk3 is one of the major active components of ginseng and is a promising candidate to regulate skin pigments and exert anti-photoaging effects on skin physiology. Ginsenoside Rk3 was mixed with a cream (G-Rk3 cream) and smeared on the skin of mice. Then, the mice were exposed to ultraviolet (UV) A (340 nm and 40 W) and UVB (313 nm and 40 W) radiation. Special attention was given to the anti-photoaging and anti-inflammatory effects of ginsenoside Rk3 on the mouse skin. Macroscopic evaluation indicated that the mouse dorsal skin looked smooth and plump even under UV irradiation for 12 weeks. Pathological analysis indicated that there was no obvious photoaging or inflammation in the mouse skin that was treated with the G-Rk3 cream. More healthy, intact, and neat collagen fibers were observed in mice treated with the G-Rk3 cream than in untreated mice. Further analysis proved that ginsenoside Rk3 could inhibit the decrease in water and hydroxyproline levels in skin tissues and the loss of superoxide dismutase and glutathione peroxidase activities in the blood. Moreover, ginsenoside Rk3 slowed or halted increases in malondialdehyde, matrix metalloproteinase (MMP)-1, and MMP-3 levels in the blood and levels of interleukin 1, interleukin 6, and tumor necrosis factor α in skin tissues. In conclusion, ginsenoside Rk3 plays a significant role in inhibiting photoaging and inflammation to protect skin health.

show abstract

Photoaging: a Review of Current Literature

Cited by 54 publications

References 55 publications

Boosting the Photoaged Skin: The Potential Role of Dietary Components

Boosting the Photoaged Skin: The Potential Role of Dietary Components

Antioxidant Activity and Anti-Photoaging Effects on UVA-Irradiated Human Fibroblasts of Rosmarinic Acid Enriched Extract Prepared from Thunbergia laurifolia Leaves

Anti-Photoaging and Anti-Inflammatory Effects of Ginsenoside Rk3 During Exposure to UV Irradiation

Contact Info

Product

Resources

About