Boosting the Photoaged Skin: The Potential Role of Dietary Components

Abstract

Skin photoaging is mainly induced by ultraviolet (UV) irradiation and its manifestations include dry skin, coarse wrinkle, irregular pigmentation, and loss of skin elasticity. Dietary supplementation of nutraceuticals with therapeutic and preventive effects against skin photoaging has recently received increasing attention. This article aims to review the research progress in the cellular and molecular mechanisms of UV-induced skin photoaging. Subsequently, the beneficial effects of dietary components on skin photoaging are discussed. The photoaging process and the underlying mechanisms are complex. Matrix metalloproteinases, transforming growth factors, skin adipose tissue, inflammation, oxidative stress, nuclear and mitochondrial DNA, telomeres, microRNA, advanced glycation end products, the hypothalamic–pituitary–adrenal axis, and transient receptor potential cation channel V are key regulators that drive the photoaging-associated changes in skin. Meanwhile, mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging. The major mechanisms of these dietary components to alleviate skin photoaging include the maintenance of skin moisture and extracellular matrix content, regulation of specific signaling pathways involved in the synthesis and degradation of the extracellular matrix, and antioxidant capacity. Taken together, the ingestion of food-derived functional components could be an attractive strategy to prevent skin photoaging damage.

Photoprotective effects of sphingomyelin-containing milk phospholipids in ultraviolet B–irradiated hairless mice by suppressing nuclear factor-κB expression

“…Skin photoaging caused by UVB exposure over a long period of time causes histological changes, such as irregular changes in keratinocytes, an increase in the number of fibroblasts and inflammatory cells, and an accelerated increase in cross-linked collagen fiber levels in the dermis (Robert et al, 2009). Furthermore, exposure of the skin to UVB also causes ROS production (Ansary et al, 2021;Geng et al, 2021). Exposure to UVB promotes continuous ROS generation in keratinocytes, and ROS are rapidly removed by enzymatic and nonenzymatic methods.…”

Ectopic Odorant Receptor Responding to Flavor Compounds: Versatile Roles in Health and Disease

“…Skin, the largest organ in the body, not only serves as an effective barrier to protect the body from diverse environmental stimuli including ultraviolet radiation and mechanical stress [ 70 ], but also functions as a sensory organ expressing multiple sensory receptors [ 71 ]. As the major cell type of the epidermal layer, keratinocytes functionally express a variety of different ORs.…”

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

“…A double-blind randomized controlled trial reported that oral vitamin D and E supplement preserves muscle mass and strength and enhances quality of life in sarcopenic older adults [63]. It was thought that the combination of vitamin C and vitamin E can efficaciously eliminate water-soluble and fat-soluble free radicals at the same time, preventing free radicals from causing oxidative damage to the cell membrane [64]. Thus, future study is warranted to investigate whether supplementation with a combination of vitamin C and vitamin E may have a more pronounced effect compared with the separate treatment of vitamin C and vitamin E. β-Carotene, a red-colored pigment found in plants and animals, is one of the most abundant provitamin A carotenoid in human diet and tissues.…”