Pharmacology and Phytochemistry of Pakistani Herbs and Herbal Drugs Used for Treatment of Diabetes

Karim, Asia; Nouman, Muhammad; Munir, Saba; Sattar, Saba

doi:10.3923/ijp.2011.419.439

Cited by 92 publications

(15 citation statements)

References 185 publications

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“…A number of plant secondary metabolites, including flavonoids and curcubitacins have previously been reported from C. colocynthis (Seger et al, 2005). It has been used in herbal treatment of diabetes (Karim et al, 2011), edema, bacterial infection and cancer. The aqueous pulp extract of the fruit is used for kidney, liver functions treatment (Rahbar and Nabipour, 2010).…”

Section: Resultsmentioning

confidence: 99%

Spectral analysis and anti-bacterial activity of methanolic fruit extract of Citrullus colocynthis using gas chromatography-mass spectrometry

Idan¹,

Al-Marzoqi²,

Hameed³

2015

Afr. J. Biotechnol.

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Phytochemicals are chemical compounds often referred to as secondary metabolites. Thirty three bioactive phytochemical compounds were identified in the methanolic extract of Citrullus colocynthis. The identification of phytochemical compounds is based on the peak area, retention time molecular weight and molecular formula. Gas chromatography-mass spectrometry (GC-MS) analysis of C. colocynthis revealed the existence of the methyl 6-oxoheptanoate, hexanoic acid, 2-isopropyl-2-methyl-5-oxo-, methyl ester, dodecanoic acid, 3-hydroxy, benzofuran,2,3-dihydro, 1,1-Cyclopropanedimethanol, 2-methyl-α-phenyl, 1,1-cyclopropanedimethanol, 2-methyl-α-phenyl, 12,15-octadecadiynoic acid, methyl ester,pregnane-3,20ß-diol, 14α,18α-[4-methyl-3-oxo-(1-oxa-4-azabutan, 3-(N,Ndimethyllaurylammonio)propanesulfonate, 2H-1-benzopyran-3,4-diol,2-(3,4-dimethoxyphenyl)-3,4dihydro-6-met, 11,13-dihydroxy-tetradec-5-ynoic acid, methyl ester, Cyclopenta[1,3]cyclopropa[1,2]cycloheptan-3(3aH)-one,1,2,3b,6,7, 4-(2,4,4-trimethyl-cyclohexa-1,5dienyl)-but-3-en-2-one, 1-tetradecanamine,N,N-dimethyl, α-D-glucopyranoside, O-α-D-glucopyranosyl-(1,fwdarw.3)-ß-D-fructo, acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-, 9octadecenamide,(z)- , butyrophenone,2´,3,4´,6´-tetramethyl-, ethyl 5,8,11,14,-eicosatetraenoate, 9,12,15octadecatrienoic acid, 2,3,-dihydroxypropyl ester, (Z,Z,Z) 5,7b,9,9a 476.241018tetrol,1a,1b,4,4a, 9,12,15-octadecatrienoic acid, 9,10-Secocholesta -5,7,10(19)triene-3,24,25,-triol,(3ß,5Z,7E)-, 9,12,15-Octadecatrienoic acid,2,3-dihydroxypropyl ester, (Z,Z,Z)-, triazido-(1,2,3,4,5-pentamethylcyclopenta-2,4-dienyl)-german, ethyl iso-allocholate, α-N-Normethadol, Octadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, phthalic acid , decyl oct-3-yl ester, 1,2-Benzenedicarboxylic acid , bis(8-methylnonyl)ester, phthalic acid, di(6-ethyl-3-octyl)ester, y-tocopherol, 1,4-ethanonaphthalene -6,9(4H)-dione,1,4a,5,8a-tetrahydro-4,5,7,10 and vitamin E. Methanolic extract of bioactive compounds of C. colocynthis was assayed for in vitro antibacterial activity against Proteus mirabilis, Escherichia coli, Pseudomonas aerogenosa, P. mirabilis, Staphylococcus aureus and Klebsiella pneumonia by using the diffusion method in agar. The zone of inhibition was compared with different standard antibiotics. The diameters of inhibition zones ranged from 4.91±0.260 to 1.03±0.200 mm for all treatments. -, 1H-cyclopropa[3,4]benz[1,2-e]ezulene -

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Section: Resultsmentioning

confidence: 99%

Spectral analysis and anti-bacterial activity of methanolic fruit extract of Citrullus colocynthis using gas chromatography-mass spectrometry

Idan¹,

Al-Marzoqi²,

Hameed³

2015

Afr. J. Biotechnol.

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“…Among the types of diabetes, the most prevalent form is type 2 diabetes, which is characterized by decreased insulin sensitivity instead of deficient insulin secretion due to autoimmune response that partially destroys pancreatic beta-cells (Karim et al, 2011). Mammalian ␣-glucosidase (␣-D-glucoside glucohydrolase, EC 3.2.1.20) is a key enzyme that catalyzes the digestion of carbohydrates.…”

Section: Introductionmentioning

confidence: 99%

Metabolite profiling of Ipomoea aquatica at different growth stages in correlation to the antioxidant and α-glucosidase inhibitory activities elucidated by 1H NMR-based metabolomics

Lawal

Mediani

Maulidiani

et al. 2015

Scientia Horticulturae

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“…In addition to the side effects, main problem with the synthetic drug therapy is a recurrence of ulcer after 1 year of the end of treatment [6]. Herbal medicines, due to cheaper accessibility, fewer or no side effects, and perceived effectiveness, are unfolding as substitute treatments to available synthetic drugs [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Ulcer Activity of the Ethanolic Extract of Phyllanthus Urinaria in Experimental Animals

Deshpande¹,

Balekar

2018

Asian J Pharm Clin Res

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Objective: The objective of this study is to investigate the antiulcer activity of the ethanolic extract of Phyllanthus urinaria (EEPU). Methods: In vivo anti-ulcer activity of EEPU was evaluated in the present study at 500 mg/kg body weight by pyloric ligation, ethanol-induced ulcer, aspirin-induced ulcer, and cold restraint-induced ulcer model. The anti-ulcer activity was assessed by determining and comparing the gastric volume, pH, free and total acidity, ulcer number and its inhibition, and ulcer severity.Result: EEPU at 500 mg/kg body weight dose showed significant antiulcer activity by decreasing ulcer index, gastric volume, pH, and free and total acidity. Gastroprotective effect of EEPU was substantiated by histopathological studies of the stomach in ulcer and treated groups.Conclusion: It can be concluded from the results that EEPU has potential antiulcer activity.

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Pharmacology and Phytochemistry of Pakistani Herbs and Herbal Drugs Used for Treatment of Diabetes

Cited by 92 publications

References 185 publications

Spectral analysis and anti-bacterial activity of methanolic fruit extract of Citrullus colocynthis using gas chromatography-mass spectrometry

Spectral analysis and anti-bacterial activity of methanolic fruit extract of Citrullus colocynthis using gas chromatography-mass spectrometry

Metabolite profiling of Ipomoea aquatica at different growth stages in correlation to the antioxidant and α-glucosidase inhibitory activities elucidated by 1H NMR-based metabolomics

Evaluation of Anti-Ulcer Activity of the Ethanolic Extract of Phyllanthus Urinaria in Experimental Animals

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