Evaluation of Anti-Ulcer Activity of the Ethanolic Extract of Phyllanthus Urinaria in Experimental Animals

Deshpande, Mangirish N; Balekar, Neelam

doi:10.22159/ajpcr.2018.v11i12.28235

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…[7] Phyllanthus urinaria is commonly known as Bhumyamalaki is an annual perennial plant indigenous to tropical Asia. [8] Whole plant as well as different parts of the plants have been traditionally used to treat different disease such as jaundice, hypertension and haemorrhoids. [9] P. urinaria have been described in Ayurvedic text "Bhavprakashnighantu" under the chapter "Guduchyadivarg" as "Pittashamak" which can be useful in reducing the hyperactivity and may have potential effect in "Pittajapasmara" (type of epilepsy as described in Ayurveda).…”

Section: Abstract a R T I C L E I N F O Alcoholic Extract Of Leaves O...mentioning

confidence: 99%

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Investigation of Anticonvulsant activity of Phyllanthus urinaria L. in Swiss albino rats

Deshpande,

Dighe,

Biradar

et al. 2022

Int. J. Pharm. Sci. Drug Res.

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Phyllanthus urinaria commonly known as Bhumyamlaki is an annual perennial plant indigenous to the Indian subcontinent and is used in traditional medicine as antidiabetic, antihypertensive, anti-inflammatory, antimalarial, and hepatoprotective. An ayurvedic text such as Bhavprakashnighantu describes P. urinaria is useful in reducing hyperactivity and beneficial in the treatment “Pittajapasmara” (type of epilepsy as described in ayurveda). The present study aimed to evaluate traditional claims in the folk medicine of bhumyamlaki (P. urinaria) which can be beneficial in the treatment of epilepsy using wistar albino rats. The anticonvulsant activity was carried out using the MES-induced seizure and PTZ-induced seizure model. In the MES-induced seizure model, animals were divided into a group of 5 (n=6). Group I was treated with saline, group II-IV was treated with ethanolic extract of P. urinaria (EPU) at the dose level of 100, 200 and 400 mg/kg. Standard drug phenytoin (25 mg/kg., p.o) was given to group V. Similar grouping was done in PTZ induced seizure model with deviation of the standard group which was treated with diazepam (4 mg/kg., i.p). Anticonvulsant activity was noted by accessing the parameters such as delay in the tonic hind limb extension, stupor, and decrease in mortality. It was observed that ethanolic extract of the whole plant of P. urinaria has significant (p < 0.001) anticonvulsant activity causing the delay in onset of tonic and clonic seizures and improved percentage protection against mortality. Further research is required to find out the exact mechanism of action.

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Section: Abstract a R T I C L E I N F O Alcoholic Extract Of Leaves O...mentioning

confidence: 99%

“…Presence of phytoconstituents such as lignans, tannins, glycosides, flavonoids was found and reported earlier by the author. [8]…”

Section: Phytochemical Parametersmentioning

confidence: 99%

Investigation of Anticonvulsant activity of Phyllanthus urinaria L. in Swiss albino rats

Deshpande,

Dighe,

Biradar

et al. 2022

Int. J. Pharm. Sci. Drug Res.

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A Review of Antiulcer Activity of Some Medicinal Plants

Deshpande,

Dighe,

Nagare

2024

J. Drug Delivery Ther.

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Peptic ulcer is a gastrointestinal disorder and with increased prevalence. Peptic ulcer is breaking of endothelial lining of stomach and exposing underlying tissues. Peptic ulcer occurs due to high secretion of acid and reduced defensive factors in stomach and duodenum. It is imbalance between aggressive and defensive factors. Non-steroidal anti-inflammatory drugs and Helicobacter pylori infection also increases the risk of peptic ulcer. Indiscriminate use of synthetic drugs leads to adverse effects and concomitant use of antibiotics potentiates drug-drug interaction thus search of drugs from natural sources especially herbs is need of hour. several herbal medicines have been evaluated for its antiulcer efficacy using several ulcer inducing models in laboratory animals. Present study aims at review of gastroprotective and ulcer healing potential medicinal herbs and compilation of data. This article is only restricted to antiulcer efficacy of the medicinal plants. This review presents information about the anti-ulcer efficacy of medicinal plants and various antiulcer models used to screen them. Keywords: Peptic ulcer, Gastric ulcer, Gastroprotective activity, Phyllanthus urinaria, Adiantum lunulatum, Ulcer healing activity

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Pharmacological Screening Techniques for Evaluation of Gastric Ulcers: Principles, Mechanism and Procedures

Shivam¹,

Sachan²,

Chandra³

2020

IJPSRR

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A gastric ulcer is the most common disease in the world. Different allopathic medicine or drugs are used for the treatment of gastric ulcers. These are effective in the treatment of ulcers but produce various side effects. These days use alternative medicine for the treatment of gastric ulcers. The natural drugs produce lower side effects in the living system therefore these are best from allopathic drugs. Identification of plants for the treatment of gastric ulcers the screenings of plants are requiring. Various methods are used to check the activity of natural drugs or herbs. These methods are called experimental animal's models. In pursuing medical knowledge and alleviating human suffering, animal models have provided invaluable details. Using different animal models, the basis of our basic knowledge of disease pathophysiology and human anatomy can primarily be traced to preclinical studies.

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Evaluation of Anti-Ulcer Activity of the Ethanolic Extract of Phyllanthus Urinaria in Experimental Animals

Cited by 3 publications

References 19 publications

Investigation of Anticonvulsant activity of Phyllanthus urinaria L. in Swiss albino rats

Investigation of Anticonvulsant activity of Phyllanthus urinaria L. in Swiss albino rats

A Review of Antiulcer Activity of Some Medicinal Plants

Pharmacological Screening Techniques for Evaluation of Gastric Ulcers: Principles, Mechanism and Procedures

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