Pharmacological evidences for the extracts and secondary metabolites from plants of the genus Hibiscus

Maganha, Elemar Gomes; Halmenschlager, Rafael da Costa; Rosa, Renato Moreira; Henriques, João Antônio Pêgas; Ramos, Ana Lı́gia Lia de Paula; Saffi, Jenifer

doi:10.1016/j.foodchem.2009.04.005

Cited by 135 publications

(84 citation statements)

References 99 publications

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“…Hibiscus sabdariffa has been used in traditional medicine in treatment for several diseases such as hypertension, hepatic disease, cardiovascular disease, atherosclerosis, and diabetes [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Detection of potential AcrAB-TolC multidrug efflux pump inhibitor in calyces extract of Hibiscus sabdariffa

Al‐Karablieh¹,

Abu-Qatouseh²,

Aburjai³

2017

J Intercult Ethnopharmacol

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Aim: The aim of this study is to investigate the occurrence of potential efflux pump inhibitor (EPI) against AcrAB-TolC efflux pump in the methanol extract of Hibiscus sabdariffa. Materials and Methods: Calyces of H. sabdariffa were purchased from the local market in April 2014, used in methanol extraction. The methanol extract of H. sabdariffa was subjected to agar plate diffusion against Escherichia coli TG1 and its ∆acrB-∆tolC followed by a thin layer chromatography (TLC) bioassay. The fraction corresponding to EPI fraction was eluted from the silica gel by methanol. The synergistic effect of antimicrobials and EPI fraction was measured by minimum inhibitory concentration (MIC) determination for E. coli and Erwinia amylovora strains. The ability of EPI fraction to enhance ethidium bromide (EtBr) accumulation was conducted. Results: E. coli TG1 was more sensitive to the methanol extracts of H. sabdariffa than E. coli ∆acrB-∆tolC. Inhibition zone corresponding to flavones on TLC bioassay plate has been formed which might be related to the fraction of potential EPI. The MIC values revealed that EPI fraction enhanced the activity of the used antimicrobials by 4-8 folds in E. coli TG1 and by 4-10 folds in E. amylovora 1189. Addition of EPI fraction in a dose-dependent manner increased the intercellular accumulation of EtBr in the wild type stains of E. coli TG1 and E. amylovora 1189. Conclusion: An EPI fraction behaves like a multidrug EPI, and further investigation should be conducted for determination the structure of chemical constituents in EPI fraction.

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Section: Introductionmentioning

confidence: 99%

“…Many antioxidant compounds have been reported in H. sabdariffa such as cyanidin 3-rutinoside, delphinidin 3-sambubioside, cyanidin 3-sambubioside, cyanidin 3-glucoside, and delphinidin 3-glucoside [18,19,27,28].…”

Section: Introductionmentioning

confidence: 99%

Detection of potential AcrAB-TolC multidrug efflux pump inhibitor in calyces extract of Hibiscus sabdariffa

Al‐Karablieh¹,

Abu-Qatouseh²,

Aburjai³

2017

J Intercult Ethnopharmacol

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“…The H. rosa-sinensis L. (family Malvaceae) evergreen medicinal shrub is commonly used in conventional medicine (red-flowered variety) as an antidiabetic and for gastrointestinal disorders, and for its cardioprotective, anticarcinogenic, antioxidative, renoprotective, hepatopretective, neuroprotective, and anti-inflammmatory properties, and for managing cognitive disorders [7][8][9][10][11]. The phytochemicals reported so far in Hibiscus rosa sinensis L. include alkaloids, amino acids, anthrocyanins, carbohydrate, flavonoids, glycosides, phytosterols, polyphenols, and vitamins [7,[12][13].…”

Section: Introductionmentioning

confidence: 99%

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

Hussain

Chaudhary

Anjum

et al. 2017

Pol. J. Environ. Stud.

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This study was initiated to anticipate the potential protective effects of flavonoid-rich fractions of Hibiscus rosa-sinenses flowers (HF) and leaves (HL) on cadmium (Cd)-induced toxicity in adult albino rabbits. Cd, being a prominent environmental pollutant, poses a threat for its widespread range of toxic expressions. A dramatic increase in total phenolics, flavonoids, and antioxidant capacity has been observed in flavonoid-rich fractions of HF and HL as compared to their crude extracts, suggesting for the rationale for their use in this study. Thirty-six male rabbits were indiscriminately allocated into six groups, including control, Cd (6.1 mg Cd/kg/day), HF and HL (200 mg HF & HL /Kg/day), Cd+HF, and Cd+HL (receiving the same doses of Cd, HF, and HL) groups. Treatment (p.o) for 60 days resulted in improvement of weight gain in Cd+HF and Cd+HL groups in comparison with the Cd group. Treatment with Cd+HF showed better results than Cd+HL by significantly decreasing (p<0.05) transaminases (AST, ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and creatinine and urea levels, while total bilirubin and albumin were increased on the 15 th , 30 th , 45 th , and 60 th days in a progressive manner when compared with the Cd receiving group. Likewise, the Cd+HF group showed better activities than Cd+HL by significantly increasing (p<0.05) superoxide dismutase, catalase, and vitamins C and E, while LPO and Cd concentrations were significantly decreased in the liver and kidney tissues when compared with Cd-intoxicated bucks.Values of these parameters in only HF and HL-receiving groups were near the control. The histopathological

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“…Another benefit of calyx roselle is helping recover from drug addiction, reducing headache (migraine), treating coughs and diarrhea [4]. In the calyx roselle contains cyanidin-3-rutinoside and delphinidin-3-glucoxyloside as the major anthocyanin [8].…”

Section: Introductionmentioning

confidence: 99%

“…Anthocyanins are currently used as a natural colorant, antioxidant, anticancer and to prevent premature aging [8]. There is possibility that crown of roselle has the same anthocyanin like the calyx, so the crown can be use.…”

Section: Introductionmentioning

confidence: 99%

ISOLATION ANTHOCYANIN FROM ROSELLE PETALS (<i>Hibiscus sabdariffa</i> L) AND THE EFFECT OF LIGHT ON THE STABILITY

Nuryanti¹,

Matsjeh²,

Anwar³

et al. 2012

Indones. J. Chem.

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Pharmacological evidences for the extracts and secondary metabolites from plants of the genus Hibiscus

Cited by 135 publications

References 99 publications

Detection of potential AcrAB-TolC multidrug efflux pump inhibitor in calyces extract of Hibiscus sabdariffa

Detection of potential AcrAB-TolC multidrug efflux pump inhibitor in calyces extract of Hibiscus sabdariffa

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

ISOLATION ANTHOCYANIN FROM ROSELLE PETALS (<i>Hibiscus sabdariffa</i> L) AND THE EFFECT OF LIGHT ON THE STABILITY

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