Pharmacokinetics of ciprofloxacin in sheep after single intravenous or intramuscular administration

Muñoz, Mario; Llovería, P.; Santos, Maísa Pavani dos; Abadía, Ana Rosa; Aramayona, J. J.; Bregante, M. A.

doi:10.1080/01652176.1996.9694613

Cited by 15 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…after intravenous administration, serum ciprofloxacin concentration (mean± SE) versus time data in dogs were best fitted to a two-compartment open model. This is comparable with the results of other studies in chicken (Anadoan et al, 2001), and in rabbits (Sahar and Eman, 2014), sheep (Munoz et al, 1996), goats (Raina et al, 1994), pre-ruminant calves (Nouws et al, 1988) and dogs (Abadia et al, 1995). Based on the compartmental model of analysis, distribution kinetic parameters, namely-distribution rate constant (α;3.46 ± 0.13 h ) suggested that rapid distribution of the drug from blood to tissues and body fluids.…”

Section: Discussionsupporting

confidence: 82%

“…In current study Distribution half-life of ciprofloxacin in dogs (0.20 ± 0.0 5) hours was longer than that in sheep (2.38 min) (Munoz et al, 1996), and pigs and pre-ruminant calves (Nouws et al, 1988), and in calves (7.8 min) suggesting thereby that the disposition kinetic behavior of drugs differ among different species of animals.…”

Section: Discussionmentioning

confidence: 93%

“…was greater comparable to that of 2.69 h and 2.44 h in calves and in pre-ruminant calves and 1.2h -1 in sheep respectively (Munoz et al, 1996), was almost comparable that of 4.85 h in horses (Yun et al, 1994), suggested that species-dependent differences in pharmaco-disposition of ciprofloxacin.…”

Section: Discussionmentioning

confidence: 94%

See 2 more Smart Citations

Pharmacokinetic Interactions between Intravenous Ciprofloxacin and Oral Ferrous Sulfate

Ibrahim¹,

Shakir²

2017

Adv. Anim. Vet. Sci.

View full text Add to dashboard Cite

| The changes in the bioavailability of oral antimicrobial activity in in vitro focus of many of the previous studies of the interaction of metal cations and quinolones. This study is the first to examine the possibility of interaction in the blood circulation using ciprofloxacin and ferrous sulfate as representative in the dogs model, and identify changes, if any, in the pharmaceutical antibiotics. To limit the direct physical interaction in the gastrointestinal. the current study design required the dogs (2.5 -3.5 Kg) to be dosed with 100 mg/kg of oral ferrous sulfate and 10 mg/kg of intravenous ciprofloxacin. Control animals received only intravenous ciprofloxacin. Blood samples were collected over time for quantitation of ciprofloxacin independently by HPLC assays. Results showed that the disposition of ciprofloxacin in control animals was biexponential with a (mean±SE) terminal elimination half-life (5.33 ± 0.14),(7.70 ± 0.08) respectively. The volume of distribution (Vd, 1.10± 0.15 L/kg), (Vd, 1.68 ± 0.33L/kg) was observed. When the antibiotic was dosed with oral iron, appeared to show a wider distribution and a longer elimination of ciprofloxacin relative to controls, antibiotic exposure (AUC 0-∞ ) was also significantly higher in the presence of iron (65.43 ± 1.60, 67.95 ± 1.78mg/ml/hr.). In conclusion, concomitant dosing oral iron lead to significant changes in the pharmacokinetics of intravenous and oral ciprofloxacin.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Pharmacokinetic Interactions between Intravenous Ciprofloxacin and Oral Ferrous Sulfate

Ibrahim¹,

Shakir²

2017

Adv. Anim. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…injection. The plasma concentration time profile was adequately described by a two-compartment open model (based on the Akaike, r 2 and positive and negative residuals) following intravenous administration, as has already been reported by Munoz et al (1996). The correlation coefficient (r 2 ) of the fit of the curve was 0.98.…”

Section: Resultsmentioning

confidence: 98%

Ciprofloxacin surf-plexes in sub-micron emulsions: A novel approach to improve payload efficiency and antimicrobial efficacy

Jain

Singodia

Gupta

et al. 2011

International Journal of Pharmaceutics

View full text Add to dashboard Cite

“…Pharmacokinetic behavior of ciprofloxacin was well characterized in calves, rabbits, ponies, sheep, rats, cow calves and buffalo calves (Nouws et al, 1988;Dowling et al, 1995;Munoz et al, 1996;Kumar et al, 1997;Zhu et al, 1999a,b;Raina et al, 2000;Jayakumar et al, 2000). Intestine is considered an important pathway in elimination of fluoroquinolones including ciprofloxacin .…”

Section: Introductionmentioning

confidence: 99%

Effect of quercetin on the disposition kinetics of ciprofloxacin

Devi¹,

Srinu²,

Rao³

2016

View full text Add to dashboard Cite

Pharmacokinetic interaction between ciprofloxacin, an antibacterial fluoroquinolone and flavonoid quercetin was investigated in the present study. Male wistar albino rats, weighing about 200-250 g were randomly divided into two groups, six rats in each group. Rats in group I (control) received ciprofloxacin alone (10 mg/kg PO). Group II received ciprofloxacin 30 min after pretreatment with quercetin (20 mg/kg PO). Rats were anaesthetized after ciprofloxacin administration for blood collection with a xylazine-ketamine combination. Blood samples were collected from jugular vein and tail clipping at predetermined time intervals prior to and at 0.33, 0.67,1, 1.5, 2, 4, 6, 8 and 12 h (20 , 40 , 6 0, 90, 12 0, 240 , 3 60, 48 0 a nd 720 min.) time interva ls after administration of ciprofloxacin. Peak plasma concentrations of ciprofloxacin will be reached in 1-2 h. after oral administration in rats. Plasma was separated by centrifuging at 3000 rpm for 10 min and stored at -20 o C until analyzed for ciprofloxacin by microbiological assay, using Escherichia coli (ATCC 25922). Based on plasma concentrations, the pharmacokinetic parameters were determined by non compa rtmenta l methods. Detectable plasma concentrations of ciprofloxacin in ra ts persisted upto 6 h when ciprofloxacin was given alone whereas ciprofloxacin was detectable up to 8 h in quercetin pretreated rats. Prior administration of quercetin modified the kinetic profile of ciprofloxacin as evidenced by the significantly (p<0.01) higher area under curve (AUC), area under the first moment curve (AUMC) and there was significant (p<0.01) decrease in V dss and Cl B when compared to untreated group.

show abstract

Pharmacokinetics of ciprofloxacin in sheep after single intravenous or intramuscular administration

Cited by 15 publications

References 18 publications

Pharmacokinetic Interactions between Intravenous Ciprofloxacin and Oral Ferrous Sulfate

Pharmacokinetic Interactions between Intravenous Ciprofloxacin and Oral Ferrous Sulfate

Ciprofloxacin surf-plexes in sub-micron emulsions: A novel approach to improve payload efficiency and antimicrobial efficacy

Effect of quercetin on the disposition kinetics of ciprofloxacin

Contact Info

Product

Resources

About