Pharmacoepidemiologic study of potential drug interactions in outpatients of a university hospital in Thailand

Janchawee, Benjamas; Wongpoowarak, Wibul; Owatranporn, T.; Chongsuvivatwong, Virasakdi

doi:10.1111/j.1365-2710.2004.00598.x

Cited by 71 publications

(76 citation statements)

References 29 publications

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“…Average 1.44 pDDIs per patient was reported by Fokter et al [4] and median pDDIs of 2 per patient was estimated by Egger et al [13]. Vasudev and Harrison demonstrated a high prevalence of pDDIs (96 %) in psychiatric wards [14]; Janchawee et al reported the highest prevalence of pDDIs in psychiatric prescriptions (57.8 %) compared to internal medicine (42.4 %), pediatrics (13.1 %) and surgery (23.3 %) [18]. Both of above studies support our results, but partially, because study of Vasudev and Harrison included a small number (n = 48) of elderly patients only while Janchawee et al carried out their study on prescriptoin data of outpatient department of a university hospital.…”

Section: Discussionmentioning

confidence: 97%

Potential Drug-Drug Interactions in Psychiatric Ward of a Tertiary Care Hospital: Prevalence, Levels and Association with Risk Factors

Ismail¹,

Iqbal²,

Khattak³

et al. 2012

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 97%

Potential Drug-Drug Interactions in Psychiatric Ward of a Tertiary Care Hospital: Prevalence, Levels and Association with Risk Factors

Ismail¹,

Iqbal²,

Khattak³

et al. 2012

Trop. J. Pharm Res

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“…[4][5][6] In the present study, we found that the frequency of potential drug-drug interactions was 72.6% in patients receiving cardiovascular drugs at Jimma University Specialized Hospital, cardiac clinic; this is higher than the frequency in Thailand (27.9%). 7 This difference could be due to the differences in the level of understanding about drug-drug interactions by prescribers in the two studies and the presence of clinical pharmacists reduce the probability of potential drug-drug interactions in study done in Thailand. In other studies the incidence of potential DDIs in elderly patients with arterial hypertension in Croatia and on ambulatory patients over 55 years of age in Mexico city were found to be 90.6% and 80% respectively which are far greater than the value obtained in this study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of potential drug-drug interactions among outpatients receiving cardiovascular medications at Jimma University specialized hospital, South West Ethiopia

Chelkeba

Alemseged

Bedada

2013

Int J Basic Clin Pharmacol

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Background: The quality of pharmacotherapy is highly dependent on the process of choosing a drug in relation to nature of the disease. Several factors should be considered in choosing optimal pharmacotherapeutics strategy including efficacy, safety, availability and cost of the drugs. The objective of this study was to assess potential drug-drug interactions and risk factors in outpatients taking cardiovascular drugs at Jimma University specialized hospital. Methods: A cross-sectional study was conducted from Feb. to April, 2011on patients visiting the cardiac clinic of Jimma University Specialized hospital. A sample of 332 outpatients who were taking cardiovascular medications at study clinic was studied. MicroMedex software was used to screen drug-drug interactions and SPSS for windows software versions-16.0 was used for data analysis. Results: A total of 1249 drugs with average of 3.76 drugs per prescription were prescribed for the 332 patients. The frequency of potential DDIs was found to be 241 (72.6%). Among these 200 (67.3%) were of "moderate" severity and 164 (55.2%) were delayed in onset. The most common potential DDI observed was between Enalapril and Furosemide (20%). Patients who prescribed many drugs (AOR=4.09; P=0.00) by medical intern had a higher risk of developing potential DDIs (AOR=4.6; P=0.00). Conclusions: Patients with cardiovascular disorders are subjected to high risk of potential drug-drug interactions and the number of drugs prescribed and educational level of the prescribers has a high significantly associated with the occurrence of potential drug-drug interactions. Therefore, it is imperative that further studies need to be conducted to identify reasons for and tackle the problem and provide appropriate mechanisms for management. [Int J Basic Clin Pharmacol 2013; 2(2.000): 144-152

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“…These studies have found rates of potential DDI ranging from approximately 5.4% to 63% (3)(4)(5)(6)(7). Differences in methods to classify drug interactions, study periods and target population contribute to these discrepancies.…”

Section: Introductionmentioning

confidence: 99%

Drug-Drug Interactions Associated with Length of Stay and Cost of Hospitalization

2009

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Purpose To evaluate the prevalence of drug-drug interactions (DDI) in hospitalized patients and to identify associated risk factors. Methods A retrospective cross-sectional analysis of prescription data and medical records from a public hospital in Brazil was conducted to identify potential DDI. Inappropriate drug combinations were identified and classified with a standard drug interaction source. Primary diagnoses were classified with Charlson Comorbidity Index (CCI). Sex, age, polypharmacy and length of stay, among other variables, were correlated with the frequency of potential DDI. Results The study included 589 patients and 3,585 prescriptions. Thirty-seven percent of the patients were exposed to at least one potential interaction during their stay in the hospital. The most frequent interacting pair was Digoxin+Furosemide (11%). In univariate analysis, several variables were associated with DDI, including sex, age, number of prescribed drugs, length and cost of hospitalization and CCI. Multivariate analysis showed that the adjusted odds of being prescribed a potential DDI among patients in polypharmacy was almost five-fold that of patients taking fewer than five drugs. Further, length of stay, CCI and cost of hospitalization were independently associated with DDI. Conclusion Analysis of prescription data found that a substantial number of potential DDI were identified. Results of this study indicate that DDI is associated with number of prescribed drugs, increased duration of stay in the hospital and cost, which suggests that DDI are a significant clinical and economic problem. Potential harm to patients could be avoided. _______________________________________________________________________________________

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Pharmacoepidemiologic study of potential drug interactions in outpatients of a university hospital in Thailand

Abstract: Potential drug interactions were common in our sample of patients. The rate of such interactions increased with the number of drugs prescribed and the patient's age.

Cited by 71 publications

References 29 publications

Potential Drug-Drug Interactions in Psychiatric Ward of a Tertiary Care Hospital: Prevalence, Levels and Association with Risk Factors

Potential Drug-Drug Interactions in Psychiatric Ward of a Tertiary Care Hospital: Prevalence, Levels and Association with Risk Factors

Assessment of potential drug-drug interactions among outpatients receiving cardiovascular medications at Jimma University specialized hospital, South West Ethiopia

Drug-Drug Interactions Associated with Length of Stay and Cost of Hospitalization

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