Pertussis Reinfection in an Adult: A Cause of Persistent Cough Not to Be Ignored

Koufakis, Theocharis; Paschala, Anastasia; Siapardanis, Dimitrios

doi:10.1155/2017/4786141

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…24 Six case studies reported mild to severe pertussis disease in adults aged 31-82 years with underlying conditions as Diabetes Mellitus Type II, Wegener's granulomatosis, multiple myeloma, renal transplantation, and acquired immune deficiency syndrome. [41][42][43][44][45][46] Mannose-binding lectin deficiency (MBL) One study evaluated the risk of pertussis in patients with MBL. Among study participants of all ages (median age of 15 years, age range: 1-71), severe MBL deficiency was significantly more frequent among the 125 pertussis patients than among the 430 controls (11.2% vs. 5.8%, odds ratio 2.0 [95% CI: 1.0-4.1]).…”

Section: Immunocompromising Conditionsmentioning

confidence: 99%

Pertussis in High Risk Groups: An Overview of the Past Quarter Century

Jenkins

Savic

Kandeil³

2020

Human Vaccines & Immunotherapeutics

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Infectious diseases can impact chronic medical conditions. However, it is currently not clear how pertussis correlates with preexisting or underlying disorders. We reviewed literature from the last 25 years to describe the burden and impact of pertussis infection in specific risk groups in individuals aged ≥11 years. Our literature search returned 543 hits, of which 18 were eligible for this review. Adolescents and adults with underlying conditions, such as asthma, chronic obstructive pulmonary disease (COPD), or obesity are potentially at increased risk of pertussis infection. Immunodeficiency and smoking have also been associated with worsened pertussis symptoms and an increased pertussis-related hospitalization rate. In patients with pertussis and preexisting asthma or COPD, symptoms were worsened, and healthcare costs were consequently increased. Further efforts are needed to close the knowledge gap and to understand the burden of pertussis in at-risk adolescent and adult populations to help inform vaccination strategies and recommendations.

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Section: Immunocompromising Conditionsmentioning

confidence: 99%

Pertussis in High Risk Groups: An Overview of the Past Quarter Century

Jenkins

Savic

Kandeil³

2020

Human Vaccines & Immunotherapeutics

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The problem of pertussis in some regions of the world

Басов

Цвиркун

Герасимова

et al. 2019

Russian Journal of Infection and Immunity

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Pertussis infection remains a high-priority issue both for Russian health care and abroad. A rise of pertussis incidence in various human age groups instigates a search for new ways to fight this infection and improve methods for its laboratory diagnostics. By taking into consideration a short-term effect induced by acellular and whole-cell vaccines, a feasibility of introducing the second or even the third pertussis revaccination is vigorously debated. Objective of the study was to analyze the experience and effectiveness of acellular pertussis vaccines in countries, which use the second and third pertussis revaccination in the National Immunization Schedule in order to have an insight into adjusting strategy and tactics of pertussis immunization In Russia. Analyzing pertussis prevalence demonstrated that despite a wide immunization coverage pertussis incidence in the last years (2008–2015) was increased in a large number of countries in the European region, as well as inAustralia,CanadaandUSA. However, the reasons for elevated pertussis incidence have not been clarified yet. On one hand, it may be accounted for by low vaccination coverage in adolescents and adults; weakened immune protection after vaccination; genetic changes in Bordetella pertussis; shortened durability of protective immunity in children vaccinated with acellular vs. whole-cell vaccine; improved monitoring and morbidity reporting, as well as improved laboratory diagnostics due to shifting from serological and bacteriological to molecular genetic assays. In an attempt to solve this issue, researchers from several countries collaborate to discuss and develop a strategy to reduce pertussis incidence. ForRussia, the most important is to empower and/or improve existing infant immunization strategy in order to provide wide coverage with the four dose pertussis vaccine for decreasing the risk of pertussis morbidity and mortality. It is worth noting the “cocoon” strategy given the high risk of pertussis infection in children of the first months of life. We believe that forRussiait is worth investigating an opportunity of using children 2–3 months of life an acellular vaccine as the first vaccination, which is expected to increase the coverage of this cohort and allow to increase proportion of children who might complete vaccination by 5 months of age. At the same time, more reasonable might be to preserve a number of age groups for pertussis vaccination in the current National Immunization Schedule, as expanding age limits for vaccination might put a risk at increasing pertussis morbidity in older individuals, which could be hard to diagnose.

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Pertussis Reinfection in an Adult: A Cause of Persistent Cough Not to Be Ignored

Cited by 2 publications

References 21 publications

Pertussis in High Risk Groups: An Overview of the Past Quarter Century

Pertussis in High Risk Groups: An Overview of the Past Quarter Century

The problem of pertussis in some regions of the world

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