Peritonite Fecal Em Ratos: Eficácia Da Lavagem Da Cavidade Peritoneal Com Solução De Cloreto De Sódio a 0,9%

Torres, Orlando Jorge Martins; Macedo, Eliane Lopes; Melo, Tereza Cristina Monteiro de; Costa, Jackeliny Garcia; Nunes, Pedro Murilo Sales; Viana, Renata Mirelli de Melo; Dietz, Ulrich

doi:10.1590/s0102-86501999000200003

Cited by 8 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…although peritoneal washing is utilized by a large number of surgeons 23 . Peritoneal washing with physiological saline of peritonitic rats, evoked lower mortality compared to plain cleaning of the cavity with compresses 24 . In group 4 rats, when the local anesthetic was added to the saline, a better result was obtained, indicating that the solution with the local anesthetics was more efficient against peritonitis than saline alone.…”

Section: Discussionmentioning

confidence: 90%

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

et al. 2008

View full text Add to dashboard Cite

PURPOSE: To study the effects of peritoneal lavage with a 2% lidocaine solution, on the survival of the rats submitted to peritonitis caused by their own feces. METHODS: Forty-eight Wistar rats, weighting between 300g and 330g (mean, 311,45 ±9,67g), were submitted to laparotomy 6 hours following induction of fecal peritonitis. Animals were randomly divided into four groups of 12 each as follows: 1- Control, no therapy; 2- Drying of the abdominal cavity; 3- Peritoneal lavage with saline and drying; 4- Peritoneal lavage with a 2% lidocaine solution and drying. Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11th day and necropsied. RESULTS: Death occurred within 52 h in all animals of group 1; within 126 h in 100% of those of group 2; within 50 h in 50% of those of group 3. All animals of group 4 survived. Survival on the 11 th day was higher in groups 3 and 4 than in groups 1 and 2 (p<0.001), and higher in group 4 than in group 3 (p<0.01). CONCLUSION: Peritoneal lavage with a 2% lidocaine saline solution without adrenaline, prevented the mortality of all animals with fecal peritonitis .

show abstract

Section: Discussionmentioning

confidence: 90%

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Previous studies confirm the importance of peritoneal lavage in the prognosis of peritonitis 2,4,7,11 . One of the most fearsome complications of peritonitis is sepsis.…”

Section: Discussionmentioning

confidence: 59%

“…There are reports of the use of saline solutions, acidic pepsin, carbolic acid, mercury chloride, salicylic acid, ethacryidine, water, camphor oil, camphor oil with ether, sodium hypochlorite, hypertonic glucose, alcohol, ether, prednisolone 13 , povidoneiodine, chlorhexidine, hydrogen peroxide and antibiotics 11 . The peritoneal lavage with saline solution has been used for many years and has shown favorable results 7 contaminating clean areas in cases of localized peritonitis, which, according to some authors, lavage is not the best management 11,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Peritoneal lavage is a procedure that dilutes enzymes which inactivate antimicrobials and digests tissues, removes toxic substances derived from bacteria or released by cell destruction, and removes foreign material such as feces, gastrointestinal secretion, urine, bile, blood, pus and fibrin 7 In this context, coconut water is a fluid that shows relevant chemical and biological characteristics, and its use for peritoneal lavage may be quite promising 8 . It has been reported the use of coconut water, in small amounts and in a short period of time, for intravenous hydration, evidencing success and improvement in the physiological conditions of the patients and showing no antigenic effects and systemic reactions 9 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Peritoneal Lavage with Coconut Water in Healing of Colon Anastomosis in Rat Abdominal Sepsis Model

et al. 2017

View full text Add to dashboard Cite

Purpose: The objective of this study was to evaluate the efficacy of peritoneal lavage with coconut water in the healing of colonic anastomoses in a model of abdominal sepsis in rats. Methods: Twelve Wistar rats were used. The animals were randomly selected and distributed in 2 groups, with six rats each. Group 1: rats with sepsis + peritoneal lavage with 0.9% saline solution and Group 2: rats with sepsis + peritoneal lavage with coconut water. Induction of abdominal sepsis was performed through the exteriorization of the cecum and ligature. After ligation, 4 perforations and gentle pressure were made in the cecum, allowing the small amount of stool to escape. The cecum was then replaced in the abdominal cavity and the abdominal incision sutured. Six hours after induction of sepsis, under anesthesia in all animals, 2 cm of colon resection and anastomosis were performed. The peritoneal lavage therapy was repeated 3 times, each wash with 5 ml of solution, which remained in the peritoneal cavity for 1 minute and then removed with sterile dry gauze. Coconut water was obtained from Cocus nucifera L specimens, with sterile technique for administration to the animals. Results: In group 2 the bursting pressure of anastomosis was 196.3±17.47 mmHg, significantly higher (p=0.001) than in the saline group, (152.8±12.31 mm/Hg). The peritoneal lavage group with coconut water presented histological scores with a significantly (p<0.001) lower inflammatory process (score 14.8±3.13) compared to the saline group (score 31.7±4.92). The count of colony forming units (CFU) in the peritoneal fluid was significantly lower (p=0.001) in the coconut water group (16.0±7.32 CFU) than in the saline group (83.5±8.62 CFU). Conclusion: The treatment of abdominal sepsis with peritoneal lavage using coconut water positively afluenced the healing of colon anastomosis in rats. It favored the bursting pressure, the reduction of inflammatory process, and bacterial colonization.

show abstract

“…Although the efficacy of peritoneal lavage is controversial in the medical literature, 19,20 a previous study conducted by the same author showed a significant reduction in mortality when local anesthetics were used in the peritoneum. 10 Local anesthetics increased survival in several studies using experimental models with mice 21 and dogs 22 , even when administered systemically.…”

mentioning

confidence: 99%

A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine

et al. 2012

View full text Add to dashboard Cite

A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine 1 Avaliação dos níveis séricos de interleucina 6 (IL-6) e fator de necrose tumoral (TNF-α) em ratos submetidos a peritonite fecal e tratado com ropivacaína intraperitoneal ABSTRACT PURPOSE:The objective of this study was to assess the cytokine serum levels of IL-6 and TNF-α in rats subjected to fecal peritonitis and treated with peritoneal lavage with 0.2% ropivacaine by peritoneal lavage. METHODS:We subjected 16 Wistar rats to laparotomy 6 hours after the induction of fecal peritonitis with autogenous stool and subsequently divided the rats randomly into 4 groups: I-control, no treatment; II-drying of the abdominal cavity; III-lavage of the abdominal cavity with 3 mL of 0.9% normal saline and drying; IV-lavage of the abdominal cavity with 3 mL of 0.2% ropivacaine and drying. Six hours following the laparotomy, the animals underwent cardiac puncture, and 1 mL of blood was collected for cytokine assessment before the animals were euthanized. RESULTS:The lavage with ropivacaine resulted in smaller TNF-α levels compared with those observed in the other treatment groups (p <0.05). Regarding IL-6 , the ropivacaine group showed lower cytokine levels than those observed in groups I and II, but there was no significant difference (p> 0.05) between groups III and IV. CONCLUSION:Peritoneal lavage with 0.2% ropivacaine was shown to reduce plasma levels of IL-6 and TNF-α in the treatment of fecal peritonitis in rats.Key words: Peritonitis. Anesthesia. Sepsis. IL-6. TNF-α. RESUMO:OBJETIVO: O objetivo do presente estudo foi avaliar as dosagens séricas das citocinas Il-6 e TNF-α em ratos submetidos à peritonite fecal e tratados com lavagem peritoneal com ropivacaína a 0,2%. MÉTODOS:Utilizaram-se 16 ratos Wistar, submetidos à laparotomia 6 horas após a indução de peritonite fecal com fezes autógenas, distribuídos aleatoriamente em 4 grupos: I-Controle, nenhum tratamento; II-Enxugamento da cavidade abdominal; III-Lavagem da cavidade abdominal com 3 ml de solução salina 0,9% e enxugamento; IV-Lavagem da cavidade abdominal com 3 ml de ropivacaína a 0,2% e enxugamento. Seis horas após a laparotomia os animais foram submetidos à punção cardíaca com retirada de 1 mL de sangue A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaineActa Cirúrgica Brasileira -Vol. 27 (7) 2012 -495 para a dosagem das citocinas e, a seguir, eutanasiados. RESULTADOS:A lavagem com ropivacaína apresentou valores de TNF-α menores do que os observados com os outros tratamentos (p<0,05). Em relação aos valores da IL-6, o grupo da ropivacaína apresentou valores menores do que os observados com os grupos I e II, mas não houve diferença estatística (p>0,05) em relação ao grupo III. CONCLUSÃO:A lavagem peritoneal com ropivacaína a 0,2% no tratamento da peritonite fecal em ratos demonstro...

show abstract

Peritonite Fecal Em Ratos: Eficácia Da Lavagem Da Cavidade Peritoneal Com Solução De Cloreto De Sódio a 0,9%

Cited by 8 publications

References 11 publications

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

Effect of Peritoneal Lavage with Coconut Water in Healing of Colon Anastomosis in Rat Abdominal Sepsis Model

A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine

Contact Info

Product

Resources

About