Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

Brocco, Marcos Célio; Paulo, Danilo Nagib Salomão; Baptista, João Florêncio de Abreu; Ferrari, Thiago Antunes; Azevedo, Thiago Caetano V. de; Silva, Alcino Lázaro da

doi:10.1590/s0102-86502008000100008

Cited by 17 publications

(19 citation statements)

References 27 publications

(34 reference statements)

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“…Previous studies demonstrated a reduction in rat fecal peritonitis mortality when the animals were treated with lavage containing lidocaine 8 and bupivacaine 9 . Ropivacaine, despite presenting an anti-inflammatory and antimicrobial effect more discrete than the other anesthetics 10 10 .…”

Section: Discussionmentioning

confidence: 96%

Histological features of peritoneal lavage with ropivacaine in rats with fecal peritonitis

et al. 2012

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PURPOSE:To evaluate the histological features in lungs, peritoneum and liver of rats subjected to fecal peritonitis and treated with peritoneal lavage with 0.2% ropivacaine. METHODS: Twenty Wistar rats were subjected to laparotomy 6 h after the fecal peritonitis induction with autogenous stool. Rats were randomly distributed into 4 groups: I -(n=5) Control, no treatment; II -(n=5) Drying of the abdominal cavity; III -(n=5) Abdominal cavity lavage with 3 ml 0.9% saline solution and drying; and IV -(n=5) Abdominal cavity lavage with 3 ml 0.2% ropivacaine and drying. The animals that died underwent necropsy, and the surviving ones were subjected to euthanasia on the 11th day post-surgery. Fragments of liver, lungs and peritoneum were removed for histological evaluation. RESULTS:The animals that received peritoneal lavage (groups III and IV) showed greater survival than the drying and control groups. Lavage with ropivacaine prevented death during the observed period. Peritoneal lavage with ropivacaine maintained the architecture of the lung, peritoneum and liver without any important histological alterations. The histopathological findings analyzed correlated with greater survival of group IV. CONCLUSION: Treatment of fecal peritonitis in rats with peritoneal lavage using 0.2% ropivacaine demonstrated a reduction in histopathological alterations related to inflammatory response and sepsis. Key words: Peritonitis. Peritoneal Lavage. Anesthetics. Sepsis. Rats. RESUMO OBJETIVO:Avaliar os aspectos histopatológicos em pulmões, peritônios e fígados de ratos submetidos à peritonite fecal e tratados com lavagem peritoneal com ropivacaína a 0,2%. MÉTODOS: Utilizou-se 20 ratos Wistar, submetidos à laparotomia 6 horas após a indução de peritonite fecal com fezes autógenas, distribuídos aleatoriamente em quatro grupos: I-(n=5) Controle, nenhum tratamento; II-(n=5) Enxugamento da cavidade abdominal; III-(n=5) Lavagem da cavidade abdominal com 3 ml de solução salina 0,9% e enxugamento ; IV-(n=5) Lavagem da cavidade abdominal com 3 ml de ropivacaína a 0,2% e enxugamento. Os animais que morreram foram necropsiados e os sobreviventes foram eutanasiados no 11º dia do pós-operatório. Retirou-se fragmentos do fígado, pulmões e do peritônio dos animais para estudo histopatológico. RESULTADOS: Os animais que receberam lavagem peritoneal (grupos III e IV) apresentaram maior sobrevida que os grupos enxugamento e controle. A lavagem com ropivacaína impediu o óbito no período avaliado. A lavagem peritoneal com ropivacaína manteve a arquitetura do pulmão, peritônio e fígado sem alterações histológicas importantes. Os achados histopatológicos analisados foram condizentes com o maior tempo de sobrevida no grupo IV. CONCLUSÃO: A lavagem peritoneal com ropivacaína a 0,2% no tratamento da peritonite fecal em ratos demonstrou reduzir as alterações histopatológicas relacionados à resposta inflamatória e sepse. Descritores: Peritonite. Lavagem Peritoneal. Anestésicos. Sepse. Ratos.Brocco MC et al.

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Section: Discussionmentioning

confidence: 96%

Histological features of peritoneal lavage with ropivacaine in rats with fecal peritonitis

et al. 2012

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“…Furthermore, the follow-up, post intraperitoneal treatment, in the present study was longer than others performed in mice 31 and rats 32 .…”

Section: Discussionmentioning

confidence: 57%

“…Additionally, the follow-up is usually short in time, and there is no mention to mean age of the animals [29][30][31][32] . Almost all of these studies lend no support to concept that antibiotics or others substances produce reduction of the morbidity and mortality for sepsis secondary to peritonitis 9,30 .…”

Section: Discussionmentioning

confidence: 99%

Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion. Response to intra peritoneal moxifloxacin combined with dexamethasone

Melo

Gadelha²,

Oliveira

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the treatment outcome of severe peritonitis in rats submitted to permanent bilateral carotid occlusion (PBCO). METHODS:Sixteen Wistar rats (mean age of 8.5 months) with PBCO underwent autogenously fecal peritonitis, and were treated with moxifloxacin combined with dexamethasone, and followed-up for 45 days. Ten rats (mean age five months) without PBCO were used as a control group. The variables were expressed by their mean and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee. RESULTS:There was a significant increase (p=0.0002) in the mortality and morbidity in older rats that underwent PBCO (study group). However, even among the survival rats presenting with severe residual abscesses both in the abdomen and thorax cavities, they present an almost normal life. CONCLUSIONS:The treatment of severe autogenously fecal peritonitis with intraperitoneal moxifloxacin combined with dexamethasone was very effective in young rats without permanent bilateral carotid occlusion. The treatment reached reasonable results in older rats with PBCO, even considering residual abscesses on abdomen and thorax. Older age was the greater risk factor for the outcome of the treatment of severe peritonitis. Sepsis remains a challenging situation, especially in elderly.Key words: Peritonitis. Quinolones. Dexamethasone. Therapy. Rats. Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion.Response to intra peritoneal moxifloxacin combined with dexamethasone

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“…In a rat septic peritonitis model, lidocaine hydrochloride solution was an effective prophylaxis against adhesion, probably due to blocking the development of oxidative stress (Brocco et al 2008, Yuzbasioglu et al 2008Arung et al 2011;Ward and Panitch 2011). In another study, lidocaine was effective for the treatment of peritonitis, while NaCl 0.9% minimally affected adhesion formation (Gallos et al 2004).…”

Section: Discussionmentioning

confidence: 97%

“…Thus, local rinsing using normal saline is usually effective for preventing adhesion formation following LOPU (Teixeira et al 2011;Teixeira et al 2013). Lidocaine rinsing solution revealed promising results in rats with respect to the prevention of intraperitoneal adhesion formation, possibly due to modulation of oxidative stress, in an experimental peritonitis model (Brocco et al 2008;Yuzbasioglu et al 2008).…”

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confidence: 99%

Intraperitoneal lidocaine hydrochloride for prevention of intraperitoneal adhesions following laparoscopic genitourinary tract surgery in ewes

Mariano¹,

Uscategui²,

Nociti³

et al. 2015

Vet. Med. - Czech

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Adhesion formation involving the genitourinary tract is common following laparoscopic procedures. To evaluate the effectiveness of intraperitoneal lidocaine hydrochloride 1% solution for the prevention of abdominal adhesions, twenty four Santa Ines ewes submitted to laparoscopic ovum pick-up, uterine puncture and local rinsing, were randomly distributed into two groups of 12 animals, according to rinsing solution: normal saline (SG) or 1% lidocaine hydrochloride solution (LG). Laparoscopy for manipulation of the reproductive tract (uterine puncture trauma model and ovum pick-up) was applied. A standard laparoscopic approach using three ports in triangulation was employed. The uterus and ovaries were rinsed at the end of the procedure (using either saline or lidocaine hydrochloride) for removal of blood clots from the ovaries and uterine horn surfaces. Inflammation was assessed postoperatively by plasma fibrinogen, and all animals underwent a second laparoscopic procedure 21 days after surgery for macroscopic assessment of adhesion formation. Four cases of adhesion were observed in each group. The plasma fibrinogen did not differ between groups and among different time points, indicating an absence of systemic inflammation following laparoscopic procedures. There were no significant differences between treatments. Both normal saline and 1% lidocaine hydrochloride were similarly effective in the prevention of adhesion formation.Keywords: reproduction; endosurgery; ovary; uterus; laparoscopic; sheep List of abbreviations ET = embryo transfer, LOPU = laparoscopic ovum pick-up, LAI = laparoscopic artificial insemination, LG = lidocaine group, SG = normal saline (0.9% NaCl) group

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Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

Cited by 17 publications

References 27 publications

Histological features of peritoneal lavage with ropivacaine in rats with fecal peritonitis

Histological features of peritoneal lavage with ropivacaine in rats with fecal peritonitis

Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion. Response to intra peritoneal moxifloxacin combined with dexamethasone

Intraperitoneal lidocaine hydrochloride for prevention of intraperitoneal adhesions following laparoscopic genitourinary tract surgery in ewes

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