Peri-implant osseointegration after low-level laser therapy: micro-computed tomography and resonance frequency analysis in an animal model

Mayer, Luciano; Gomes, Fernando Vacilotto; Oliveira, Marília Gerhardt de; Moraes, João Feliz Duarte de; Carlsson, Lennart

doi:10.1007/s10103-016-2051-3

Cited by 23 publications

(17 citation statements)

References 34 publications

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“…The animal studies have all reported that photo therapy with low levels of light can provide greater bone-implant interface strength and also improve the osseointegration process (Table 2). 6,15,18,[20][21][22][23][24][25][26][27][28][29][30][31][32][33] Removal torque values increased significantly along with time even after a single laser irradiation compared with a nonirradiated control group in the study by Boldrini et al 24 Gomes et al have interestingly shown that higher energy levels (10 or 20 J/cm 2 ) promote more implant-bone contact compared with a lower energy (5 J/cm 2 ). Better ISQ values were also observed in the 20 J/cm 2 group (this article was published in the Quintessense journal in the same year with the Mayer et al bibliography).…”

Section: Can Photobiomodulation Influence Ti Implant Stability?mentioning

confidence: 99%

“…Most of these studies reported positive effects in terms of promotion of bone formation around Ti implants, and higher bone implant contacts (BICs) were reported ( Table 1). [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Many researchers have confirmed that low-level light therapy can promote bone formation by stimulatory effects on osteoblasts, which can lead to greater osteo-integration of Ti implants. This has been evaluated in different study designs and laser irradiation parameters.…”

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confidence: 99%

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Photobiomodulation in Periodontology and Implant Dentistry: Part 2

Gholami

Asefi

Hooshyarfard

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Part 1 of this article can be located at www.liebertpub.com/doi/10. 1089/photob.2019.4710.) Objective: Finding evidence-based treatment strategies for low-level light therapy and the correct incorporation of these treatment methods in the clinical practice of periodontics. Background: Photobiomodulation has been shown to have biostimulatory, anti-inflammatory, and analgesic effects that can be beneficial in periodontal and dental implant treatment procedures. Methods: In this review, we have addressed some clinical questions regarding the potential clinical application of low-level light irradiation and its photobobiomodulatory effects in periodontology and implantology. The literature was searched for in vivo (animal or clinical) articles written in English in four electronic databases of PubMed, Scopus, Google Scholar, and Cochrane Library until April 2019. Only studies with low irradiation doses without any thermal effects used only for their photobiomodulatory purposes were included. Results: We were able to find relevant studies for all of our questions, and positive effects for the application of light therapy were reported in most of the studies. However, there is still a great deal of heterogeneity in terms of study designs and most importantly in light irradiation devices and the parameters used. Due to this issue, it was not possible to reach specific evidence-based irradiation protocols for the questions addressed in this review. Conclusions: Based on our search results, an obvious positive effect of low-level light therapy on stimulation of healing of periodontal soft and hard tissues and reduction of inflammation can be seen. Future well-designed randomized control studies with the same irradiation settings and systematic reviews evaluating the studies found on the questions mentioned are necessary to reach evidence-based recommendations.

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Section: Can Photobiomodulation Influence Ti Implant Stability?mentioning

confidence: 99%

mentioning

confidence: 99%

Photobiomodulation in Periodontology and Implant Dentistry: Part 2

Gholami

Asefi

Hooshyarfard

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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“…The RFA has been successfully used in clinical studies as the only non-invasive, functional measurement method. It is regarded as a sufficient tool for evaluating the course of intraosseous implant stability in clinical practice [9,[51][52][53] and in preclinical settings [54][55][56][57][58]. We found that ISQ values moderately changed with healing time.…”

Section: Discussionmentioning

confidence: 72%

“…Some of the studies did not detect any change during healing between primary and secondary stabilities with RFA [59,60]. In contrast, other results showed a dynamic increase in ISQ values from primary to secondary stability [9,[54][55][56][57][58]. Taken together, RFA is an appropriate method for determining differences between very early and late stages of osseointegration.…”

Section: Discussionmentioning

confidence: 95%

Development of a quantitative preclinical screening model for implant osseointegration in rat tail vertebra

et al. 2018

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Objectives Functional tooth replacement and bone regeneration are parts of the daily practice in modern dentistry, but wellreproducible and relatively inexpensive experimental models are still missing. We aimed to develop a new small animal model to monitor osseointegration utilizing the combination of multiple evaluation protocols. Material and methods After cutting the tail between the C4 and C5 vertebrae in Wistar rats, costume made, parallel walled, nonthreaded implants were placed into the center of the tail parallel with its longitudinal axis using a surgical guide. Osseointegration of the titanium implants was followed between 4 and 16 weeks after surgery applying axial extraction force, and resonance frequency analysis as functional tests, and histomorphometry and micro-CT as structural evaluations. Results In functional tests, we observed that both methods are suitable for the detection of the time-dependent increase in osseointegration, but the sensitivity of the pull-out technique (an approximately five times increase with rather low standard error) was much higher than that of the resonance frequency analysis. In structural evaluations, changes in the detected bone implant contact values measured by histomorphometry (yielding 1.5 times increase, with low variations of data) were more reliable than micro-CT based evaluations to screen the developments of contact between bone and implant. Conclusion Our results provide evidence that the caudal vertebrae osseointegration model is useful for the preclinical evaluation of implant integration into the bone. Clinical relevance The combination of the biomechanical and structural tests offers a well-reproducible small animal system that can be suitable for studying the integration of various implant materials and surface treatments.

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“…30 In the last decades, the use of LLLT has been widely studied in dentistry. [31][32][33][34] In oral implantology, some studies have assessed the use of LLLT to improve the primary stability at the early stages of osseointegration [7][8][9] ; however, most of these studies were performed in animal models. As stated earlier, the last systematic review on this topic suggested that there is a lack of evidence about the influence of LLLT on implant stability in humans.…”

Section: Discussionmentioning

confidence: 99%

Influence of low‐level laser therapy on implant stability in implants placed in fresh extraction sockets: A randomized clinical trial

Lobato

Kinalski

Martins

et al. 2020

Clin Implant Dent Rel Res

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Background: Low-level laser therapy (LLLT) has been suggested to improve primary stability at the early stages of osseointegration in animal models. However, there is still scarce evidence about its influence on implant stability in humans. Purpose: To assess the influence of LLLT on implant stability in implants placed in fresh extraction sockets. Material and methods: A randomized controlled trial was designed according to the SPIRIT guidelines and is reported following the CONSORT. Patients were randomly allocated according to control or LLLT groups. LLLT consisted in the application of GaAlAs laser (808 nm, avg. power density: 50 mW, circular spot diameter and area: 0.71 cm/0.4cm 2) applied in six points in contact mode with peri-implant soft tissue (1.23 minutes in each point of application; dose per point 11 J) before bone perforation and after suturing. The total dose resulted in 66 J per application moment. This LLLT protocol was applied only in the dental implant placement session. Implant stability was by ISQ at implant placement (T 0) and the abutment selection (T a). Digital radiographs for T 0 and T a were used to assess the distance between the implant platform and alveolar bone crest, in millimeters. T-test and Shapiro-Wilk test were used to analyze data between groups using the implant as a unit of analysis. Results: Fifty implants were placed in 44 patients. The insertion torque ranged from 15 to 60 N.cm (mean 35.64 ± 13.34). Two implants of the LLLT and one of the control groups were lost to follow-up and one implant of the control group failed to osseointegrate (4.3%). ISQ at T 0 ranged from 17 to 79 (mean 59.33 ± 13.05) and from 40 to 89 (mean 66.46 SD ± 11.56) at T a. No differences were observed when comparing the groups with ISQ difference (P = .433) or radiographical peri-implant alterations (P = .261). Conclusions: LLLT did not influence implant stability in implants placed in fresh extraction sockets when assessed at healing abutment installation.

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Peri-implant osseointegration after low-level laser therapy: micro-computed tomography and resonance frequency analysis in an animal model

Cited by 23 publications

References 34 publications

Photobiomodulation in Periodontology and Implant Dentistry: Part 2

Photobiomodulation in Periodontology and Implant Dentistry: Part 2

Development of a quantitative preclinical screening model for implant osseointegration in rat tail vertebra

Influence of low‐level laser therapy on implant stability in implants placed in fresh extraction sockets: A randomized clinical trial

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