Perfil proteico e metabolismo oxidativo de cordeiros experimentalmente infectados pelo Haemonchus contortus e suplementados com selênio e vitamina E

Nicolodi, Paula Rocha Sampaio Junchem; Camargo, Emmanuel Veiga de; Zeni, Diego; Rocha, Ricardo Xavier da; Cyrillo, Fernanda Cavallini; Souza, Fernando Nogueira de; Libera, Alice Maria Melville Paiva Della; Bondan, Carlos; Leal, Marta Lizandra do Rêgo

doi:10.1590/s0103-84782010000300010

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…Different results were obtained by Nicolodi (2008) with selenium and vitamin E supplementation in sheep experimentally infected by H. contortus , and by Mattos et al. (2005) with such supplementation in goats naturally infected by H. contortus .…”

Section: Resultsmentioning

confidence: 93%

SHORT COMMUNICATION: Neutrophil oxidative metabolism and haemogram of sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E

Camargo

Lopes

Costa

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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The objective of this study was to evaluate neutrophil oxidative metabolism and haemogram in sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E. Twenty male Corriedale sheep were utilised and distributed into four experimental groups each with five animals infected with larvae: G1--supplemented with sodium selenite, 0.2 mg/kg body weight (bw) given intramuscularly (IM); G2--supplemented with sodium selenite and vitamin E, 0.2 mg/kg bw and 2000 IU per animal, respectively, both IM; G3--supplemented with vitamin E, 2000 IU per animal IM; G4--not supplemented. A haemogram and the number of parasite eggs were determined in samples of blood and faeces, respectively, on days zero (T0), 20 (T1), 40 (T2) and 60 (T3) and nitroblue tetrazolium (NBT) assays were performed on heparinized blood samples taken on days zero, 30 and 60. A lower total leucocyte count was detected in G1 in relation to G4 at T4. Lymphocytes were reduced in G1 in relation to G3 and G4 at T3. In both non-stimulated (NBT-NS) and stimulated (NBT-S) dye reduction assays, there was reduced activity at 60 days, in relation to other times in the groups treated with selenium (G1 and G2). On the basis of results obtained, we conclude that supplementation with selenium provides better antioxidant protection to neutrophils.

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Section: Resultsmentioning

confidence: 93%

SHORT COMMUNICATION: Neutrophil oxidative metabolism and haemogram of sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E

Camargo

Lopes

Costa

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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“…Zn and Cu are known to play an important role in the animal organism (Herdt and Hoff, 2011). In addition, some researchers have shown that the use of Cu and other minerals, such as nutritional supplements may help controlling the parasites (Nicolodi et al, 2010;Fausto, 2011). However, there is still lack of studies using the combination of minerals in an attempt to provide better conditions to face the severe parasitism caused by H. contortus.…”

Section: Introductionmentioning

confidence: 99%

Immune response of lambs experimentally infected with Haemonchus contortus and parenterally treated with a combination of zinc and copper

Schafer

Leal

Molento

et al. 2015

Small Ruminant Research

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“…Nicolodi et al (2010) relataram que não há influência da suplementação com selênio e vitamina E no perfil proteico e metabolismo oxidativo quando os cordeiros se encontram severamente parasitados por Haemonchus contortus.…”

Section: Resultsunclassified

Peroxidação lipídica em cabras com anemia e doença respiratória tratadas com ferro por via parenteral

Santos

Botteon

et al. 2014

Pesq. Vet. Bras.

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RESUMO.-Objetivou-se avaliar a progressão da doença e o dano oxidativo em cabras com anemia e doença respirató-ria mediante aplicação de ferro parenteral. Foram estudadas seis cabras, adultas, com parâmetros eritrocitários indicativos e anemia e manifestações de doença respiratória (tosse, espirros e secreção nasal). O grupo controle foi composto por seis cabras adultas, sadias. As cabras de ambos os grupos após serem submetidos à avaliação clínica receberam dose similar (0,5g) de hidróxido férrico em complexo dextrânico, por via intramuscular. Amostras de sangue colhidas com EDTA, antes da aplicação do ferro e 48 horas depois foram utilizadas para determinação da concentração de substâncias reativas ao ácido tiobarbitúrico (TBARS). Nas cabras doentes antes da aplicação do ferro os valores de TBARS foram equivalentes aos valores mensurados nos controles antes e após a aplicação do ferro (p>0,05). Os valores mensurados nas cabras doentes foram muito mais elevados (p<0,001) no mesmo grupo de animais depois da aplicação do ferro e nos controles antes e após a aplicação. A aplicação do ferro agravou a condição clinica dos animais com doença respiratória, sendo evidenciada uma condição de toxidade refletida pelo estresse oxidativo. Assim sendo, não se deve recomendar tal suplementação nos caprinos acometidos de doenças do aparelho respiratório. Aimed to evaluate the progression of the disease and oxidative damage in goats with anemia and respiratory disease by application of parenteral iron. Six goats, adults, with anemia and respiratory disease (coughing, sneezing and nasal discharge) were studied. The control group was composed of six adults goats, healthy. The goats of both groups after undergoing clinical evaluation received similar dose (0.5g) of ferric hydroxide in complex dextran intramuscularly. Blood samples collected in EDTA before the application of iron and 48 hours were taken for determination of concentration of thiobarbituric acid reactive substances (TBARS). In patients goats before the application of iron TBARS values were equivalent to the measured values in the control group before and after applying the iron (p>0.05). The values measured in patients goats were significantly higher (p<0.001) in the group of animals even after the application of iron and controls before and after application. The application of iron worsened the clinical condition of the animals with respiratory disease, evidencing a condition of toxicity reflected by oxidative stress. Therefore, one should not recommend to supplementation in goats with respiratory diseases.

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Perfil proteico e metabolismo oxidativo de cordeiros experimentalmente infectados pelo Haemonchus contortus e suplementados com selênio e vitamina E

Abstract: Perfil proteico e metabolismo oxidativo de cordeiros experimentalmente infectados peloHaemonchus contortus e suplementados com selênio e vitamina E

Cited by 9 publications

References 26 publications

SHORT COMMUNICATION: Neutrophil oxidative metabolism and haemogram of sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E

SHORT COMMUNICATION: Neutrophil oxidative metabolism and haemogram of sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E

Immune response of lambs experimentally infected with Haemonchus contortus and parenterally treated with a combination of zinc and copper

Peroxidação lipídica em cabras com anemia e doença respiratória tratadas com ferro por via parenteral

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