Peptide-based hydrogel nanoparticles as effective drug delivery agents

Ischakov, Rafael; Adler‐Abramovich, Lihi; Buzhansky, Ludmila; Shekhter, Talia; Gazit, Ehud

doi:10.1016/j.bmc.2013.03.012

Cited by 125 publications

(76 citation statements)

References 28 publications

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“…While polysaccharides are very customizable through grafting and modification, their natural variability in composition and molecular weight can be a disadvantage when compared with well-defined synthetic polymers prepared with techniques such as controlled radical polymerization [114][115][116], or other synthetic nanostructures such as dendrimers [117] and peptide-based nanoparticles [118][119][120][121]. It is necessary to develop techniques for large-scale production of refined polysaccharides, having well-defined molecular weights and chemical compositions, which are suitable for safe application of these materials as DDSs.…”

Section: Resultsmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

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Section: Resultsmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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“…Hydrogel is a three-dimensional polymer network, in which the individual hydrophilic polymer chains are connected by the physical or chemical bond. It has been one of the most appealing polymeric materials used for preparing sustained-release systems that have a great impact on pharmaceutical development and regenerative medicine [3,4]. As a drug carrier, hydrogel has very obvious advantages, such as good biocompatibility, no side-effects, good biodegradability performance [5,6] and so on.…”

Section: Introductionmentioning

confidence: 99%

Aptamer-functionalized hydrogel as effective anti-cancer drugs delivery agents

Wang

Xia

Cai

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…A possible alternative is to develop a nanotechnology based system for delivery of the anticancer drug into the tumor [24][25][26][27][28][29][30][31]. External patches [32] have been investigated for use with imiquimod [33], however an implantable system has not yet been developed.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma

Garrett

Niiyama

Kotsuchibashi

et al. 2015

Fibers

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Abstract:In this paper we investigate a potential new treatment option for basal cell carcinoma using electrospun polymer nanofibers. Poly(ε-caprolactone) fibers incorporated with the anti-cancer drug imiquimod were successfully produced for the first time. These fibers were characterized and their diffusion release profile tested in vitro. A range of different electrospinning parameters were investigated in order to determine the most effective approach in optimizing the fibers for future in vivo testing. Characterization showed stable and homogeneous distribution of imiquimod. Although the drug was released faster than what would be needed to replicate the current treatment model, this system would ideally allow for a treatment option which reduces side effects and is more convenient for the patient than the current topical treatment.

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Peptide-based hydrogel nanoparticles as effective drug delivery agents

Cited by 125 publications

References 28 publications

Self-assembled polysaccharide nanostructures for controlled-release applications

Self-assembled polysaccharide nanostructures for controlled-release applications

Aptamer-functionalized hydrogel as effective anti-cancer drugs delivery agents

Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma

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