Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma

Garrett, R.; Niiyama, Eri; Kotsuchibashi, Yohei; Uto, Koichiro; Ebara, Mitsuhiro

doi:10.3390/fib3040478

Cited by 26 publications

(19 citation statements)

References 50 publications

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“…Although electrospinning is the simplest and easiest method that can produce a fiber of nano dimension, there are many factors that influence web characteristics [4,11,30]. Usually, the factors that affect electrospinning can be classified into two categories.…”

Section: Effects Of Electrospun Conditions On the Fiber Morphologymentioning

confidence: 99%

The Design of Temperature-Responsive Nanofiber Meshes for Cell Storage Applications

Maeda

Kim

Aoyagi

et al. 2017

Fibers

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Abstract:Here we report on the fabrication and characterization of temperature-responsive electrospun nanofiber meshes using N-isopropylacrylamide homopolymer (PNIPAAm). The effect of molecular weight on fiber formation and their thermoresponsive shrinking/dissolution behaviors were investigated. The PNIPAAm fiber meshes showed much faster temperature-dependent shrinking or dissolution than that of its corresponding film due to its unique fibrous structure. By utilizing these quick and dynamic shrinking/dissolution properties, we successfully demonstrated the temperature-modulated "on-off" capture/release systems for macroscopic or mesoscopic-scale objects. Finally, we explored the potential application of PNIPAAm meshes for cell storage.

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Section: Effects Of Electrospun Conditions On the Fiber Morphologymentioning

confidence: 99%

The Design of Temperature-Responsive Nanofiber Meshes for Cell Storage Applications

Maeda

Kim

Aoyagi

et al. 2017

Fibers

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“…The PCL nanofibers were prepared by the electrospinning method. Briefly, PCL was dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) (20 wt/v %) and electrospun for 2 h onto an aluminum substrate using 20 kV at a flow rate of 1 mL/h [ 22 ]. To immobilize HVJ-E particles on PCL nanofiber meshes, layer-by-layer (LbL) assembly technique was employed ( Figure 2 a).…”

Section: Resultsmentioning

confidence: 99%

Inactivated Sendai Virus (HVJ-E) Immobilized Electrospun Nanofiber for Cancer Therapy

et al. 2015

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Inactivated Hemagglutinating Virus of Japan Envelope (HVJ-E) was immobilized on electrospun nanofibers of poly(ε-caprolactone) by layer-by-layer (LbL) assembly technique. The precursor LbL film was first constructed with poly-L-lysine and alginic acid via electrostatic interaction. Then the HVJ-E particles were immobilized on the cationic PLL outermost surface. The HVJ-E adsorption was confirmed by surface wettability test, scanning laser microscopy, scanning electron microscopy, and confocal laser microscopy. The immobilized HVJ-E particles were released from the nanofibers under physiological condition. In vitro cytotoxic assay demonstrated that the released HVJ-E from nanofibers induced cancer cell deaths. This surface immobilization technique is possible to perform on anti-cancer drug incorporated nanofibers that enables the fibers to show chemotherapy and immunotherapy simultaneously for an effective eradication of tumor cells in vivo.

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“…The nanofiber mesh was fabricated using a versatile and costeffective process called electrospinning. Electrospinning uses electrical forces to produce polymer fibers with diameters ranging from tens of nanometers to several micrometers [9][10][11][12][13]. In early works, electrospinning was limited to the fabrication of nanofibers from organic polymers due to the stringent requirement on the viscoelastic behavior of the electrospinning solution.…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Towards a Rational Design of Zeolite-Polymer Composite Nanofibers for Efficient Adsorption of Creatinine

Takai

Kurimoto

Nakagawa

et al. 2016

Journal of Nanomaterials

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This report describes the compositional and structural design strategy of a zeolite-polymer composite nanofiber mesh for the efficient removal of uremic toxins towards blood purification application. The nanofiber is fabricated by electrospinning composite solution of biocompatible poly(ethylene-co-vinyl alcohol) (EVOH) and zeolite particles which are capable of selectively adsorbing uremic toxins such as creatinine. By controlling electrospinning conditions carefully, the incorporated zeolites in EVOH were found to correspond closely to the feed ratios. Elemental mapping images of Si show that zeolites were uniformly blended within the fibers. The fabricated composite fibers successfully adsorbed creatinine from solution and the adsorption capacity reached a maximum at 12 h. The crystallinity of the nanofiber was also controlled by varying the composition of ethylene content in EVOH. Less crystallinity resulted in higher creatinine adsorption capacity due to the barrier property of EVOH. Cytotoxicity assay demonstrated that the composite fibers showed less toxicity than free zeolite particles which killed more than 95% of cells. The proposed composite fibers, therefore, have the potential to be utilized as a new approach to removing creatinine selectively from the bloodstream.

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Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma

Cited by 26 publications

References 50 publications

The Design of Temperature-Responsive Nanofiber Meshes for Cell Storage Applications

The Design of Temperature-Responsive Nanofiber Meshes for Cell Storage Applications

Inactivated Sendai Virus (HVJ-E) Immobilized Electrospun Nanofiber for Cancer Therapy

Towards a Rational Design of Zeolite-Polymer Composite Nanofibers for Efficient Adsorption of Creatinine

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