Peppermint oil (Mintoil®) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial

Cappello, G.; Spezzaferro, M.; Grossi, Laurino; Manzoli, Lamberto; Marzio, L.

doi:10.1016/j.dld.2007.02.006

Cited by 170 publications

(113 citation statements)

References 24 publications

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“…Former studies have suggested peppermint oil as a possible treatment for IBS symptoms [18,21]. In one randomized placebo-controlled clinical study, a 4-week treatment with Colpermin improved the overall abdominal symptoms in patients with IBS [19]. Another study demonstrated that Colpermin could alleviate the severity of abdominal pain in 79% of patients [21].…”

Section: Discussionmentioning

confidence: 97%

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The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

et al. 2009

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Herbal remedies, particularly peppermint, have been reported to be helpful in controlling symptoms of irritable bowel syndrome (IBS). We conducted a randomized double-blind placebo-controlled study on 90 outpatients with IBS. Subjects took one capsule of enteric-coated, delayed-release peppermint oil (Colpermin) or placebo three times daily for 8 weeks. We visited patients after the first, fourth, and eighth weeks and evaluated their symptoms and quality of life. The number of subjects free from abdominal pain or discomfort changed from 0 at week 0 to 14 at week 8 in the Colpermin group and from 0 to 6 in controls (P < 0.001). The severity of abdominal pain was also reduced significantly in the Colpermin group as compared to controls. Furthermore, Colpermin significantly improved the quality of life. There was no significant adverse reaction. Colpermin is effective and safe as a therapeutic agent in patients with IBS suffering from abdominal pain or discomfort.

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Section: Discussionmentioning

confidence: 97%

“…This finding has led medical researchers to investigate the effectiveness of peppermint oil in IBS treatment [16,17]. Previous studies have suggested that an enteric-coated peppermint-oil formulation (Colpermin) might be helpful in relieving some symptoms of irritable bowel syndrome [18,19].…”

Section: Introductionmentioning

confidence: 96%

The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

et al. 2009

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“…Once initiated, the onset of efficacy may occur as early as week 2 [19], but may be delayed until week 6 [20]. Adverse effects with peppermint oil in the trials were similar to placebo, with 2 cases of heartburn, one of which resulted from a patient chewing the medication [20,21]. In addition to heartburn, adverse effects associated with peppermint oil in the general population included nausea and vomiting.…”

Section: Resultsmentioning

confidence: 99%

Medication Management of Irritable Bowel Syndrome

Trinkley

Nahata²

2014

Digestion

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Background: Irritable bowel syndrome (IBS) is a complex syndrome that is difficult to manage. Here we present the evidence supporting medication treatments for specific IBS symptoms, discuss evidence-based management of IBS with medications including dose regimens and adverse effects and review progress on research for new IBS treatments. Summary: Currently, there is evidence to support improvements in specific IBS symptoms following treatment with loperamide, psyllium, bran, lubiprostone, linaclotide, amitriptyline, trimipramine, desipramine, citalopram, fluoxetine, paroxetine, dicyclomine, peppermint oil, rifaximin, ketotifen, pregabalin, gabapentin and octreotide and there are many new medications being investigated for the treatment of IBS. Key Message: Of the medications with demonstrated improvements for IBS symptoms, rifaximin, lubiprostone, linaclotide, fiber supplementation and peppermint oil have the most reliable evidence supporting their use for the treatment of IBS. Onset of efficacy for the various medications has been noted to be as early as 6 days after initiation; however, the efficacy of most medications was not assessed prospectively at predefined periods. Additional studies of currently available and new medications are ongoing and are needed to better define their place in therapy and expand therapeutic options for the treatment of IBS. The most promising new medications for IBS include a variety of novel pharmacologic approaches, most notably the dual μ-opioid receptor agonist and δ-opioid antagonist, JNJ-27018966.

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“…The Food and Drug Administration (FDA), however, does not seem to examine these products with the same scrutiny used for conventional drugs. Cappello et al (Cappello et al, 2007) and Kingham (Kingham, 1995) showed that peppermint essential oil could relieve abdominal pain by reducing smooth muscle spasm in the gastrointestinal tract. In the current study, peppermint oil could significantly decrease heartburn, constipation, and belching.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Effects of Cumin, Peppermint, and Milk of Magnesia on Gastrointestinal Complications after Caesarean Section

Niaki¹,

Atarod²,

Omidvar³

et al. 2016

GJHS

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Context: Gastrointestinal problems are common after Cesarean section. During the past three decades, there has been an increasing trend in the use of herbal plants in the treatment of various medical conditions. Material and Methods:A total of 83 patients undergoing non-emergency Cesarean delivery in Imam Hospital were randomly selected. Patients with underlying diseases, history of gastrointestinal problems, fever, intestinal adhesion, longer-than-usual Cesarean section, and lack of cooperation were excluded. The subjects were informed about the study objectives and procedure and asked to provide written informed consent. They were then randomly assigned into three groups of cumin, peppermint, MOM. Gastrointestinal complications were assessed 20, 40, 60, and 120 minutes after drug administration. Statistical Analysis Used:The collected data were analyzed using Fisher's exact and chi-square tests in SPSS for Windows 18.0. Results:There was no significant difference between three groups according to incidence of gastrointestinal side effects after Cesarean section at the mentioned intervals.Conclusions: Cumin and peppermint were as effective as MOM.

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Peppermint oil (Mintoil®) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial

Cited by 170 publications

References 24 publications

The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

Medication Management of Irritable Bowel Syndrome

Comparing the Effects of Cumin, Peppermint, and Milk of Magnesia on Gastrointestinal Complications after Caesarean Section

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