The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

Merat, Shahin; Khalili, Sara; Mostajabi, Pardise; Ghorbani, Anahita; Ansari, Reza; Malekzadeh, Reza

doi:10.1007/s10620-009-0854-9

Cited by 128 publications

(110 citation statements)

References 19 publications

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“…Based on these studies, at best peppermint has a marginal efficacy. However, it is important to note that there are no adverse reactions although there was a high dropout rate in one trial [72] .…”

Section: Peppermintmentioning

confidence: 96%

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Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

2017

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The gastrointestinal tract digests and absorbs dietary nutrients, protects the body against physical and chemical damage from contents in its lumen, provides immunity against external antigens, and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome and inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Because these diseases are associated with oxidative stress, a host of antioxidant supplements are used for maintenance and recovery of the gut functions. However, the benefits of these supplements have not been established. The available 80 human trials were rated for levels of confidence and for benefits of the antioxidant supplements. For Crohn's disease, the supplements for which clear benefits occurred in at least 2 studies were allopurinol, Boswellia serrata (frankincense or shallaki), Artemesia species (wormwood), Tripterygium wilfordii (léi gōng téng), and omega-3 fatty acids. Similar beneficial supplements for ulcerative colitis were allopurinol, Matricaria chamomilla (chamomile), Curcuma longa (curcumin in turmeric), and omega-3 fatty acids. There was also a clear benefit for ulcerative colitis in 2 studies where a multiherbal Chinese medicine preparation and an Ayurvedic medicine preparation were used. For irritable bowel syndrome, there was only a marginal benefit of some of the antioxidant supplements. Thus, some antioxidant supplements may be beneficial at certain stages of specific diseases. This is consistent with the current concept that antioxidants act by inhibiting oxidative stress pathways in a tissue- and environment-specific manner and not by simply acting as scavengers.

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Section: Peppermintmentioning

confidence: 96%

“…Table 1 lists 7 studies that examined the benefits of peppermint in IBS [67][68][69][70][71][72] . Based on these studies, at best peppermint has a marginal efficacy.…”

Section: Peppermintmentioning

confidence: 99%

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

2017

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“…The most recent review included 5 trials for a total of 482 patients (107)(108)(109)(110)(111); it showed a statistically significant positive effect of peppermint oil versus placebo, with a NNT of 3 (95% CI: 2-4) (90). However, there was significant heterogeneity among studies.…”

Section: Efficacymentioning

confidence: 99%

Clinical Practice Guideline: Irritable bowel syndrome with constipation and functional constipation in the adult

Mearin¹,

Ciriza²,

Mínguez³

et al. 2016

Rev Esp Enferm Dig

103

151

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In this Clinical Practice Guideline we discuss the diagnostic and therapeutic approach of adult patients with constipation and abdominal complaints at the confluence of the irritable bowel syndrome spectrum and functional constipation. Both conditions are included among the functional bowel disorders, and have a significant personal, healthcare, and social impact, affecting the quality of life of the patients who suffer from them. The first one is the irritable bowel syndrome subtype, where constipation represents the predominant complaint, in association with recurrent abdominal pain, bloating, and abdominal distension. Constipation is characterized by difficulties with or low frequency of bowel movements, often accompanied by straining during defecation or a feeling of incomplete evacuation. Most cases have no underlying medical cause, and are therefore considered as a functional bowel disorder. There are many clinical and pathophysiological similarities between both disorders, and both respond similarly to commonly used drugs, their primary difference being the presence or absence of pain, albeit not in an "all or nothing" manner. Severity depends not only upon bowel symptom intensity but also upon other biopsychosocial factors (association of gastrointestinal and extraintestinal symptoms, grade of involvement, and perception and behavior variants). Functional bowel disorders are diagnosed using the Rome criteria. This Clinical Practice Guideline has been made consistent with the Rome IV criteria, which were published late in May 2016, and discuss alarm criteria, diagnostic tests, and referral criteria between Primary Care and gastroenterology settings. Furthermore, all the available treatment options (exercise, fluid ingestion, diet with soluble fiber-rich foods, fiber supplementation, other dietary components, osmotic or stimulating laxatives, probiotics, antibiotics, spasmolytics, peppermint essence, prucalopride, linaclotide, lubiprostone, biofeedback, antidepressants, psychological therapy, acupuncture, enemas, sacral root neurostimulation, surgery) are discussed, and practical recommendations are made regarding each of them.

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“…Good tonic for the stomach and liver. Eliminates thread worms in children, relieves colic due to worms, and due to indigestion It is considered to be good for digestion and effective in the treatment of irritable bowl syndrome (Cappello et al 2007;Merat et al 2010) Therapeutic uses of edible plants in Bangalore city, India 309…”

Section: Mentha Sativamentioning

confidence: 99%

Therapeutic uses of edible plants in Bangalore city, India: combining health with cooking practices through home herbal gardens

Torri

Hollenberg

2011

Environ Dev Sustain

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This article examines the therapeutic uses and perceptions of edible plants cultivated in home herbal gardens in the city of Bangalore, Southern India. We suggest that an examination of edible plants within a therapeutic context facilitates a more comprehensive understanding of the role that plants play both in the diet and in the health of urban populations such as in Bangalore. We conclude by reinforcing the importance of promoting awareness of the combined value of medicinal and edible plants through their cultivation in home gardens and the role of local health knowledge in health promotion.

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The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

Cited by 128 publications

References 19 publications

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

Clinical Practice Guideline: Irritable bowel syndrome with constipation and functional constipation in the adult

Therapeutic uses of edible plants in Bangalore city, India: combining health with cooking practices through home herbal gardens

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