Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: A prospective, double-blind, randomized, placebo-controlled study

Ghotbi, Sh; Parsanezhad, Mohammad Ebrahim; Dehbashi, Sanaz; Alborzi, Saeed; Alborzi, Mahshid

doi:10.1016/j.jmig.2006.06.024

Cited by 46 publications

(24 citation statements)

References 28 publications

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“…There are few randomized, controlled trials in humans assessing the efficacy of PTX after surgical treatment of endometriosis (26)(27)(28)(29). Some investigators have noted a trend for improved fertility (12%-14% increase in pregnancy rates after a 6-month period) after treatment with PTX, which did not reach statistical significance (27,29).…”

Section: Discussionmentioning

confidence: 99%

Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model

Vlahos

Gregoriou

Deliveliotou

et al. 2010

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model

Vlahos

Gregoriou

Deliveliotou

et al. 2010

Fertility and Sterility

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“…Pentoxifylline is a phosphodiesterase inhibitor with anti-inflammatory properties and has been studied in infertile women with endometriosis. A single small-scale RCT with 60 cases reported a nonsignificant increase in pregnancy rates with pentoxifylline use (31% vs. 18.5% with placebo in a 12-month period) [53] , while a prospective, double-blind, randomized, placebo-controlled study did not agree with the former authors [54] . Current data based on the established pharmacopoeia indicate that medical treatment of endometriosis-associated infertility is not effective and should not be pursued.…”

Section: Medical Treatment Of Endometriosis-associated Infertilitymentioning

confidence: 95%

Advances in Treatment Options of Endometriosis

Özkan

Arıcı

2008

Gynecol Obstet Invest

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Endometriosis, defined as the presence of endometrial tissue outside the uterus, is a challenging condition associated with substantial morbidity. Management of endometriosis must be individualized according to the desired treatment outcome, whether it is relief of pain, improvement of fertility, or the prevention of recurrence. For alleviation of endometriosis-associated pain, medical treatment is generally successful, with no medical agent being more efficacious than another in spite of significantly differing side-effect profiles. Surgical therapy has also been demonstrated to reduce pain scores in comparison with expectant management, although conservative surgery has been frequently associated with recurrence. The efficacy of combination therapies still remains to be clarified. For treatment of endometriosis-associated infertility, suppressive medical treatment has been proven to be detrimental to fertility and should be discouraged, while surgery is probably efficacious for all stages. Controlled ovarian hyperstimulation with intrauterine insemination is recommended in early-stage and surgically corrected endometriosis. Combined surgery with GnRH analog treatment has been proposed to be first-line therapy, followed by IVF as second-line therapy in advanced cases. More rigorously designed randomized clinical trials focusing on the endocrinological, immunological, and genetic aspects of endometriosis are necessary to refine conclusions regarding the etiopathogenesis and therapeutic innovations of this perplexing disease.

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“…FDA has approved the agent to treat symptoms of intermittent claudication resulting from peripheral arterial disease [71]. It has also been used to treat glomerular proteinuric nephropathy [72], multi-infarct dementia [73], Peyronie's disease [74], sarcoidosis [75], peripheral neuropathy [76], sickle cell disease [77], alcoholic [78] and non-alcoholic steato-hepatitis [79], endometriosis [80] and radiation-induced fibrosis [81,82].…”

Section: Pentoxifyllinementioning

confidence: 99%