Penicillin Treatment of Early Syphilis—A Preliminary Report

Mahoney, John F.; Arnold, R. C.; Harris, Ad

doi:10.2105/ajph.33.12.1387

Cited by 160 publications

(55 citation statements)

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“…It was recognised as a form of treatment for venereal diseases [31][32][33] prior to the introduction of salvarsan [34][35][36][37] and penicillin in the 20th century [38]. Mercury was provided to mothers during pregnancy [39] children, and infants in the form of ointments, calomel teething powders [24,40,41], and injections [41,42].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton

Ioannou

Henneberg

et al. 2015

Journal of Anthropology

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Without the presence of “caries sicca,” “sabre shins,” and nodes/expansion of the long bones with superficial cavitation, differential diagnosis of venereal syphilis and tuberculosis (TB) may be difficult as various infections produce similar responses. However, congenital syphilis has distinctive features facilitating a diagnosis. A case study of remains of a juvenile European settler (probably male, 8–10 years old) (B70) buried in the 19th century and excavated in 2000 from the cemetery of the Anglican Church of St. Marys in South Australia is presented. B70 demonstrated that the two diseases might have been present in the same individual, congenital syphilis and TB. Widespread destruction of vertebral bodies and kyphosis-related rib deformations indicate advanced TB. Severe dental hypoplasia is limited to permanent incisors and first molars; there is pitting on the palate, periosteal reaction on the skull vault, and thinned clavicles. Dental signs are not limited to “screwdriver” central incisors and mulberry molars. Apical portions of the crowns of permanent upper, lower, central, and lateral incisors have multiple hypoplastic-disorganized defects; deciduous canines have severely hypoplastic crowns while possibly hypoplastic occlusal surfaces of lower deciduous second molars are largely destroyed by extensive caries. These dental abnormalities resemble teeth affected by mercurial treatment in congenital syphilitic patients as described by Hutchinson.

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Section: Introductionmentioning

confidence: 99%

Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton

Ioannou

Henneberg

et al. 2015

Journal of Anthropology

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“…C'est ce qui fut fait pour la première fois le 14 octobre 1943, lorsque Mahoney, Arnold et Harris présen-tèrent devant l'American Public Health Association à New York une communication sur le traitement de la syphilis par la pénicilline, qui mettait fin à quatre siècles d'inefficacité et de toxicité thérapeutiques [79,80].…”

Section: éPilogueunclassified

La syphilis dans les hôpitaux de l’Assistance publique pendant la Grande Guerre. Enjeux sanitaires et patriotiques

Tilles

2015

Annales de Dermatologie et de Vénéréologie

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“…42 Penicillin was evidently effective, and by 1947 it had become the gold standard treatment for the disease. This new drug was so successful that by the mid-1950s the incidence of syphilis had plummeted and many believed it might be eradicated entirely.…”

Section: Introduction Of Penicillin In the Treatment Of Syphilismentioning

confidence: 99%

Syphilis and Human Experimentation From World War II to the Present: A Historical Perspective and Reflections on Ethics

Cuerda-Galindo

Sierra

López

et al. 2014

Actas Dermo-Sifiliográficas (English Edition)

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Penicillin Treatment of Early Syphilis—A Preliminary Report

Cited by 160 publications

References 0 publications

Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton

Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton

La syphilis dans les hôpitaux de l’Assistance publique pendant la Grande Guerre. Enjeux sanitaires et patriotiques

Syphilis and Human Experimentation From World War II to the Present: A Historical Perspective and Reflections on Ethics

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