More than 7 years have elapsed since the efficacy of penicillin in the treatment of early syphilis, was first reported (1). In this relatively short period, penicillin has been adopted throughout the United States, and much of the world, for the treatment of all stages of syphilis.Concepts of epidemiology, immunology, serology, and treatment have been radically altered. The hazards of the antisyphilitic therapies of the past have been eliminated; the treatment period has been shortened from years to days; and a modern type of "therapia sterilisans magna" has been realized. These factors have brought about many necessary adjustments as well as advantageous developments in the administrative, clinical, and educational phases of venereal disease control.Of the several specifications for an ideal therapy, cure of all patients is of primary importance.
In this report a resume is given of a series of experimental studies carried out in rabbits to develop effective local prophylactic agents against syphilis transmitted by application of a spirochaetal emulsion to the penile mucous membrane (Table). These studies were made at the Venereal Disease
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