Pengaruh Ekstrak Etanol Daun Kelor (Moringa oleifera) pada Ekspresi Insulin dan Insulitis Tikus Diabetes Melitus

Abstract

AbstrakKandungan quercetin pada Moringa oleifera secara ilmiah memiliki potensi sebagai antioksidan dan antiinflamasi dengan menghambat aktivitas NF-ĸ B, serta triterpenoid menstimulasi regenerasi sel β pankreas dan meningkatkan sekresi insulin. Effect of Ethanol Extract of Moringa oleifera Leaves on Insulin Expression and Insulitis in Diabetes Mellitus Rats AbstractQuercetin content in Moringa oleifera has scientific potential antioxidant and anti-inflammation effects by inhibiting the activity of NF-ĸB. In addition, triterpenoids stimulate pancreatic β cell regeneration and increases insulin secretion. This study aimed to discover the effect of Moringa oleifera extract on insulitis and insulin expression in pancreas of Sprague-Dawley male rats. The study was performed at the laboratory of Food and Nutrition Unit of The Inter University Center of Gadjah Mada University and the laboratory of Histology and Cell Biology Faculty of Medicine Gadjah Mada University during May-July 2013. This was a randomized post test only controlled group study. Twenty four rats were included. Blood glucose test was performed on the third day after streptozotocin induction to ensure that all rats were in hyperglycemic condition. The rats were then divided into three groups: one control group and two treatment groups receiving Moringa oleifera ethanolic leaves extract for 21 days in doses of 250 and 500 mg/kg/day, respectively. Histopathological analysis of pancreas were performed by evaluating insulitis based on the infiltration of mononuclear inflammatory cells to the Langerhans islets. Insulin expression was evaluated using Allred score. Statistical analysis used was Kruskal-Wallis test, followed by Mann-Whitney with a level of significance of p<0.05. The insulitis degree and insulin expression of the two treatment groups were significantly different compared to the control group (p<0.005). It can be concluded that Moringa oleifera ethanolic leaf extract doses of 250 and 500 mg/kg/day cause higher insulin expression and lower insulitis degree than in the control group. [MKB. 2015;47(2):69-76]

Pandemi Covid_19 Berdampak pada Peningkatan Penjualan Produk Kelor “Moringa Kidom” CV. Tri Utami Jaya di NTB

“…Tamanan moringa yaitu berasal dari selatan gunung Himalaya diutara barat India. Daun moringa ini memiliki komposisi nutrisi kimia, asam amino, asam lemak, beta karoten, mineral, dan vitamin E (Sulistyorini et al, 2015). Manfaat dan khasiat tanaman kelor moringa terdapat pada semua bagian tanaman baik daun, batang, akar, maupun biji.…”

“…Kelor memiliki vitamin dan nutrisi yang kompleks sesuai penelitian yang dilakukan oleh (Sulistyorini et al, 2015;Syarifah, Tezan and Muflihani, 2015;Gopalakrishnan et al, 2016;dan Aminah at al., 2015). Rempah-rempah yang kaya akan khasiatnya, menjadikan produk kelor "Moringa Kidom" sebagai obat/jamu alternatif untuk pencegahan Covid_19.…”

POTENSI DAUN KELOR (Moringa oleifera) SEBAGAI AGEN ANTI-HIPERGIKEMIA : STUDI LITERATUR REVIEW

“…Quercetin dengan konsentrasi tinggi banyak ditemukan pada daun kelor (Moringa oleifera). Aktivitas quercetin sebagai antioksidan bekerja dengan menurunkan peroksidasi lipid (MDA) dan meningkatkan aktivitas enzim antioksidan, dan mampu menstimulasi sel-sel progenitor pada saluran pankreas untuk berdiferensiasi membentuk sel pulau Langerhans baru atau sel endokrin sehingga pemberian ekstrak daun Moringa oleifera yang mempunyai kandungan di berbagai vitamin, mineral, dan asam amino esensial yang akan berguna dalam regenerasi sel [10]. Quercetin bekerja dengan menghambat produksi LPS (Lipopolysaccharide) atau sitokin Macrophages Like Cell dengan meregulasi ekspresi protein iNOS (Nitric oxide synthase) yaitu molekul pensinyalan seluler untuk membantu memodulasi sekresi insulin dan transkripsi MRA (Mesenteric Resistance artery).…”

Diffusion Study of Cream Formula of Lyophilized Ethanol Extract of Moringa oleifera L. Leaves

“…Various studies about the use of Moringa leaf have been discovering, such as an analgesic, antipyretic, and anti-inflammatory. Another study showed that Moringa leaf has antioxidants, anticancer, and antimicrobial activities, later known it also decreases blood sugar levels (Ahisma, 2013;Sulastri E, et.al., 2018;Sulistyorini, et al, 2015;Yanti, 2010).…”