Diabetes Melitus (DM) dikenal sebagai gangguan metabolisme karbohidrat yang ditandai dengan tingginya kadar gula dalam darah (hiperglikemia). Menurut data International Diabetes Federation (IDF) 2017, jumlah diabetisi mencapai 415 juta jiwa dan diperkirakan akan terus meningkat pada tahun 2040 sekitar 642 juta jiwa (55%). Salah satu alternatif pengobatan untuk menanggulangi penyakit diabetes yaitu tanaman herbal diantaranya daun kelor (Moringa oleifera) yang kaya akan nutrisi, seperti phytochemical, karoten, senyawa flavonoid, senyawa phenoid, kalsium, besi, protein, vitamin serta memiliki kandungan antioksidan yang dapat menstabilkan radikal bebas sehingga dapat dijadikan proteksi terhadap diabetes melitus. Tujuan Penelitian ini yaitu untuk mengetahui potensi daun kelor (Moringa oleifera) dalam menurunkan kadar gula darah berdasarkan data ilmiah yang dikumpulkan. Metode penelitian ini menggunakan metode literatur Review dengan pencarian jurnal ilmiah secara online pada database Science Direct dan Google Scholar terbitan tahun 2010-2020 dengan teknik pengumpulan data menggunakan pendekatan PICO (Population, Intervention, Comparasion, Outcome). Hasil tinjauan literatur beberpaa jurnal, daun kelor (Moringa oleifera) berpotensi sebagai penurun kadar glukosa darah yang sangat efektif, selain itu daun kelor (moringa oleifera) menunjukkan pengaruh yang signifikan terhadap profil lipid, resistensi insulin, penurunan glukosa darah, dan penurunan berat badan secara signifikan. Hal ini menunjukkan bahwa daun Moringa oleifera terbukti memiliki efek dapat menurunkan kadar gukosa dalam darah.
Stroke is a functional brain disorder in the form of nerve paralysis (deficit neurologic) due to obstruction of blood flow to the brain. Based on the Basic health research (Riskesdas) in 2018, the prevalence of stroke in Indonesia increased from 7% (2013) to 10.9% (2018) so it is necessary to optimize therapy for patients. Stroke treatment therapy, in general, uses two or more drugs (polypharmacy) so that this is able to increase the potential for drug interactions in patients either pharmacokinetic or pharmacodynamic. This study was aimed to investigate the potential for pharmacodynamic drug interactions and management of drug interaction events on stroke patients with polypharmacy therapy in hospital. The method of this study was retrospective observational. Data were analyzed descriptively using Stockley's Drug Interaction, Drug Interaction Facts, www.drugs.com database, and Medscape Drug Interactions Checker. The sampling technique employed in this study was total sampling method. The findings revealed that potential drug interactions on stroke patients in the hospital were 61.40% (n = 27 samples). The most mechanism pattern was pharmacodynamic interaction between aspirin-amlodipine (13.8%) and the most severity was in moderate level (77.78%).
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