Pediatric multisystem inflammatory syndrome associated with a new coronavirus infection: unresolved issues

Lobzin, Yu. V.; Вильниц, А. А.; Kostik, Mikhail M.; Бехтерева, М. К.; Усков, А. Н.; Скрипченко, Н В; Бабаченко, И. В.; Ivanov, Dmitry O.; Alexandrovich, Yu. S.; Konstantinova, Yu. E.; Дондурей, Е. А.; Konev, A. I.; Карасев, В. В.

doi:10.22625/2072-6732-2021-13-1-13-20

Cited by 16 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Тяжелые формы НКИ нередко становятся причиной критических состояний и летальных исходов, включая декомпенсированную дыхательную недостаточность, ОРДС, септический шок, сердечную, печеночную, почечную недостаточность, нарушения коагуляции, поражение центральной нервной системы [3,[9][10][11] .Кроме того, у детей может развиться тяжелый мультисистемный воспалительный синдром, связанный с SARS-CoV-2 [2,4,8,9,12] . Инфицирование SARS-CoV-2, тяжелое течение заболевания и летальные исходы в следствие COVID-19 у детей встречаются реже, чем у взрослых [1,15,16] .…”

Section: особенности тяжелых форм новой коронавирусной инфекции (Covi...unclassified

Features of severe forms of new coronavirus infection (COVID-19) in children

Bannova,

Ivanov,

Alexandrovich

et al. 2024

Pediatr (SPb)

View full text Add to dashboard Cite

BACKGROUND: The problem of the complicated course of COVID-19 and deaths in children with severe comorbid pathology is relevant. Severe forms of the disease are often the cause of critical conditions and deaths, including decompensated respiratory failure, acute respiratory distress syndrome, septic shock, cardiac, hepatic, renal insufficiency, coagulation disorders, damage to the central nervous system. AIM: The aim is to analyze the features of the course of COVID-19 in children who require mandatory hospitalization in specialized hospitals for background pathology, to identify predictors of the development of severe forms of COVID-19 in order to choose the optimal ways of treating this pathology. MATERIALS AND METHODS: Under the supervision of the St. Petersburg State Pediatric Medical University in the department for children with new coronavirus infection COVID-19 with intensive care and intensive care wards in the period 2020–2022 with a confirmed diagnosis of “new coronavirus infection” there were 791 patients aged 0 to 17 years. The diagnosis was made on the basis of clinical and epidemiological data, the results of a comprehensive laboratory and instrumental study. The severity of the disease was determined in accordance with the methodological recommendations of the Ministry of Health of the Russian Federation. RESULTS: The severe form of COVID-19 was diagnosed in 34 patients out of 791 (4.3%). Adverse outcomes were 1.4%. In 27 out of 34 children (79.4%), new coronavirus infection occurred against the background of severe comorbid pathology. Pneumonia was diagnosed in 91.2% of cases. 88.2% of patients needed oxygen therapy. CONCLUSIONS: Severe forms of COVID-19 in children are characterized by high fever with severe intoxication, respiratory tract damage with a significant volume of lung damage (CT-3 and CT-4) with the development of multiple organ failure. Predictors that require mandatory hospitalization in specialized hospitals for background pathology in severe forms of COVID-19 are: primary immunodeficiency conditions, oncohematological pathology with postcytostatic aplasia of hematopoiesis, severe organic lesions of the central nervous system, epilepsy, protein-energy deficiency of 3–4 degrees, bronchopulmonary dysplasia, atypical emolytic uremic syndrome with acute kidney damage. Comprehensive treatment of such patients should be carried out by a multidisciplinary team in a specialized department with extensive diagnostic and therapeutic capabilities.

show abstract

Section: особенности тяжелых форм новой коронавирусной инфекции (Covi...unclassified

Features of severe forms of new coronavirus infection (COVID-19) in children

Bannova,

Ivanov,

Alexandrovich

et al. 2024

Pediatr (SPb)

View full text Add to dashboard Cite

show abstract

“…Стоит отметить, что среди госпитализированных в отделение реанимации преобладают мальчики [3]. Уже в марте 2020 г. появились данные, что у детей старше 4 лет чаще развивается мультисистемный воспалительный синдром (МВС), среди пациентов с которым также превалируют мальчики [15,16].…”

Section: обоснованиеunclassified

Pneumococcal Septicemia after COVID-19 in Teenager: Clinical Case

et al. 2021

View full text Add to dashboard Cite

There is a hypothesis among the scientists that COVID-19 and SARS-CoV-2 have negative effect on the immune system. Many reports on multisystem inflammatory syndrome (MIS) development after COVID-19 are published worldwide. Whereas, the impact of this infection on prevalence and course of any other infectious diseases has not been studied. The aim of the study is to draw attention to the estimation of other infectious diseases course after COVID-19 by analyzing the clinical case of pneumococcal septicemia in 17 years old boy who has undergone COVID-19. We obtained data about COVID-19 during the analysis of the child's medical history. The course of infectious process was similar to the course of multisystem inflammatory syndrome in children (MIS-C), compared by clinical manifestations. The results of ELISA blood assay have proved it: we revealed IgG to SARS-CoV-2. However, PCR test revealed S. pneumoniae DNA in blood, so MIS-C diagnosis was excluded. The role of SARS-CoV-2 in other diseases in postcovid period can not be excluded, and it requires further studies. Development of screening and rehabilitation principles is recommended despite the severity of COVID-19 in children.

show abstract

Retrospective analysis of cases of multisystem inflammatory syndrome associated with COVID-19 infection in children in the Republic of Komi

Korableva,

Payusova,

Berestnev

et al. 2023

Sovremennaâ revmatologiâ

View full text Add to dashboard Cite

Multisystem inflammatory syndrome in children (MIS-C) is a new and relatively rare nosology in children associated with COVID-19 infection, which is characterized by severe multiple organ involvement and poses an immediate life threat.Objective: to analyze the clinical, laboratory and instrumental examination data of patients with MIS-C associated with COVID-19 infection, hospitalized in the Republican Infectious Diseases Hospital of the Komi Republic and the Republican Children's Clinical Hospital of the Ministry of Health of the Komi Republic from April 2020 to April 2022.Material and methods. The retrospective study included 15 patients. The diagnosis was verified according to the Guidelines of the Russian Ministry of Health (version dated July 3, 2020). The results of clinical, instrumental and laboratory examination of patients were evaluated in comparison with literature data.Results and discussion. The prevalence of MIS-C in the Komi Republic was 5.5 per 100,000 persons under 18 years of age. The majority of the study cohort were males (66.7%), the median age was 3 years. 46.7% of cases were between the ages of 8 and 14 years. At the onset of clinical manifestations, all patients had fever and gastrointestinal symptoms. In 80% of children, pathological changes of skin and mucous membranes, as well as respiratory disorders were revealed. Involvement of the cardiovascular system in the pathological process was noted in 66.7% of cases. Less frequently, the urinary tract was affected. When analyzing laboratory data, an increase in the level of inflammatory markers, as well as lymphopenia and neutrophilia, were noted. Most patients received therapy with intravenous immunoglobulin and systemic glucocorticoids, as well as anticoagulants and acetylsalicylic acid. The outcomes of the disease in most cases were favorable, in 6.7% of patients a lethal outcome was recorded.Conclusion. The analysis of cases of MIS-C illustrates the high frequency of seroconversion to the SARS-CoV-2 virus, the predominance of males compared to females (2:1 ratio), the prevalence of the age group under 4 years, the heterogeneity of clinical manifestations and generally favorable prognosis. The diversity of clinical features of COVID-19 warrants a high degree of suspicion for MIS-C, as well as the development of a predictive tool, the "MIS-C Suspicion Index".

show abstract

Pediatric multisystem inflammatory syndrome associated with a new coronavirus infection: unresolved issues

Cited by 16 publications

References 10 publications

Features of severe forms of new coronavirus infection (COVID-19) in children

Features of severe forms of new coronavirus infection (COVID-19) in children

Pneumococcal Septicemia after COVID-19 in Teenager: Clinical Case

Retrospective analysis of cases of multisystem inflammatory syndrome associated with COVID-19 infection in children in the Republic of Komi

Contact Info

Product

Resources

About