Patients' Profile, Clinical Presentations and Histopathological Features of Colo-rectal Cancer in Al Hassa Region, Saudi Arabia

Abstract

Background: Patients' demographics, presenting clinical and histopathological features for colo-rectal cancer (CRC) are important factors for patients' outcome and disease prognosis. This study aimed to describe the pattern of CRC in terms of patients' demographics, main presenting symptoms and histopathological features in Al Hassa region of Saudi Arabia. Subjects and Methods: A retrospective hospital records-based study which included reviewing of patients' records diagnosed with CRC at three general hospitals in Al Hassa region, Saudi Arabia. A compilation form was designed to collect information regarding socio-demographics, age at diagnosis; referral sites and the main presentations at CRC diagnosis. sites and the main presentations at CRC diagnosis. Histopathological reports were reviewed to delineate the main cytopathologic features, prominent cytological characteristics, the presence of predisposing pathology, and disease stage. Results: Of the 142 cases with CRC, 15.5% and 33.1% were affected before 40 and 50 years of age respectively. Emergency rooms were main referral sites for CRC cases (31.0%). Right colon was affected in 16.9% while left colonic lesions accounted for 62.7%. Intestinal obstruction was the main presentations (41.5%), and 26.1% presented with symptoms indicating distant metastastic lesions. Adenocarcinoma was the predominant pathological lesions (86.6%). Metastastic CRC was diagnosed in 62.7%. Duke's staging showed that 22.5% and 40.1% of lesions were classified into C and D categories respectively. Conclusion: Saudi patients with CRC present late with distant metastasis, and advanced disease stage. A sizeable proportion of patients developed the lesions at relatively young age. Screening recommendations should be enacted and revised in response to current change with younger age of affection.

Colorectal Cancer in India: An Iceberg Analysis From North India

“…These figures are in concordance with the studies done by Amin et al [4] in which the mean age was 54.8±14.5 and 63.5 years respectively. Gender proportion was more in favour of males irrespective of the age groups and tumor subtype with Male:Female ratio being 1.8:1.…”

Descriptive Epidemiology of Colorectal Cancer in University Malaya Medical Centre, 2001 to 2010

“…Other factors affecting delay in diagnosis of colorectal cancer in our settings are poor knowledge of the symptoms, attitudes to screening as well as health care personnel failure to suspect colorectal cancer in patients presenting with a rectal bleeding (Hashim et al, 2010;Kong et al, 2010;Hashim et al, 2011). Advanced colorectal cancer disease in 2/3rd of the patients was also reported among patients in other Asian counties (Amin et al, 2012;Hajmanoochehri et al, 2014) Our younger (≤ 40 years) patients had significantly higher tumor grade compared to older age groups. This is in line with previous studies where colorectal cancers were found to be more aggressive, spread faster and are associated with a poor prognosis in younger age groups (Chou et al, 2011;Amin et al, 2012).…”

“…Advanced colorectal cancer disease in 2/3rd of the patients was also reported among patients in other Asian counties (Amin et al, 2012;Hajmanoochehri et al, 2014) Our younger (≤ 40 years) patients had significantly higher tumor grade compared to older age groups. This is in line with previous studies where colorectal cancers were found to be more aggressive, spread faster and are associated with a poor prognosis in younger age groups (Chou et al, 2011;Amin et al, 2012). The higher proportion of young Malays affected suggests that this section of the population may need to be screened at a younger age than the Asian Pacific guidelines suggest.…”

Outcome of Rectal Cancer in Patients Aged 30 Years or Less in the Pakistani Population

“…However, studies have not used 30 years as the age cut-off. In most of the published studies age limit for young onset rectal cancer is 40 years (Domergue et al, 1988;Liang et al, 2003;Amin et al, 2012;You et al, 2012). Kansakar and colleagues attempted to determine changing trends in etiopathology in colorectal cancer patients in Nepal.…”