Descriptive Epidemiology of Colorectal Cancer in University Malaya Medical Centre, 2001 to 2010

Magaji, Bello Arkilla; Moy, Foong Ming; Roslani, April Camilla; Law, Chee Wei

doi:10.7314/apjcp.2014.15.15.6059

Cited by 23 publications

(24 citation statements)

References 19 publications

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“…Mean age at diagnosis was 53 years that showed a rising trend between the studies periods divided by 5 years. There was no significant difference in age between men and women, and the male to female sex ratio was 1.3 which is similar to study of Ahmad Reza Baghestani and the study of Bello Arkilla Magaji (Baghestani et al, 2014, Magaji et al, 2014. In the studies of Safaee 2005Safaee -2009, published by Ministry of Health and the Cancer Registry, the mean age of patients was 53 years old with similar sex ratio to our study (Safaee et al, 2012).…”

Section: Discussionsupporting

confidence: 90%

Demographic Survey of Four Thousand Patients with 10 Common Cancers in North Eastern Iran over the Past Three Decades

Nikfarjam

Massoudi²,

Salehi³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 90%

Demographic Survey of Four Thousand Patients with 10 Common Cancers in North Eastern Iran over the Past Three Decades

Nikfarjam

Massoudi²,

Salehi³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…A total of 13.4% of the surgeries were performed as emergencies. More details of these patients are published elsewhere [12]. …”

Section: Resultsmentioning

confidence: 99%

Survival rates and predictors of survival among colorectal cancer patients in a Malaysian tertiary hospital

et al. 2017

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BackgroundColorectal cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death globally. It is the second most common cancer among both males and females in Malaysia. The economic burden of colorectal cancer is likely to increase over time owing to its current trend and aging population. Cancer survival analysis is an essential indicator for early detection and improvement in cancer treatment. However, there was a scarcity of studies concerning survival of colorectal cancer patients as well as its predictors. Therefore, we aimed to determine the 1-, 3- and 5-year survival rates, compare survival rates among ethnic groups and determine the predictors of survival among colorectal cancer patients.MethodsThis was an ambidirectional cohort study conducted at the University Malaya Medical Centre (UMMC) in Kuala Lumpur, Malaysia. All Malaysian citizens or permanent residents with histologically confirmed diagnosis of colorectal cancer seen at UMMC from 1 January 2001 to 31 December 2010 were included in the study. Demographic and clinical characteristics were extracted from the medical records. Patients were followed-up until death or censored at the end of the study (31st December 2010). Censored patients’ vital status (whether alive or dead) were cross checked with the National Registration Department. Survival analyses at 1-, 3- and 5-year intervals were performed using the Kaplan-Meier method. Log-rank test was used to compare the survival rates, while Cox proportional hazard regression analysis was carried out to determine the predictors of 5-year colorectal cancer survival.ResultsAmong 1212 patients, the median survival for colorectal, colon and rectal cancers were 42.0, 42.0 and 41.0 months respectively; while the 1-, 3-, and 5-year relative survival rates ranged from 73.8 to 76.0%, 52.1 to 53.7% and 40.4 to 45.4% respectively. The Chinese patients had the lowest 5-year survival compared to Malay and Indian patients. Based on the 814 patients with data on their Duke’s staging, independent predictors of poor colorectal cancer (5-year) survival were male sex (Hazard Ratio [HR]: 1.41; 95% CI: 1.12, 1.76), Chinese ethnicity (HR: 1.41; 95% CI: 1.07,1.85), elevated (≥ 5.1 ng/ml) pre-operative carcino-embryonic antigen (CEA) level (HR: 2.13; 95% CI: 1.60, 2.83), Duke’s stage C (HR: 1.68; 95% CI: 1.28, 2.21), Duke’s stage D (HR: 4.61; 95% CI: 3.39, 6.28) and emergency surgery (HR: 1.52; 95% CI: 1.07, 2.15).ConclusionsThe survival rates of colorectal cancer among our patients were comparable with those of some Asian countries but lower than those found in more developed countries. Males and patients from the Chinese ethnic group had lower survival rates compared to their counterparts. More advanced staging and late presentation were important predictors of colorectal cancer survival. Health education programs targeting high risk groups and emphasizing the importance of screening and early diagnosis, as well as the recognition of symptoms and risk factors should be implemen...

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“…However, our study did not find any significant gender difference in the anatomic distribution of tumors. A latest study from Malaysia, reviewing 1, 212 colorectal cancer patients undergoing treatment between January 2001 and December 2010, showed that significant ethnic differences in age and site distribution (Magaji et al, 2014). Therefore, we suggested that when making references to the statistics of colorectal cancer, the ethnic factor must be taken into account.…”

Section: Discussionmentioning

confidence: 97%

Distribution Characteristics of 3,369 Chinese Colorectal Cancer Patients for Gender, Age, Location and Tumor Size During Colonoscopy

Cai

Wang²,

Liao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Studies have shown the existence of gender-and age-related differences in the incidence and anatomic distribution of colorectal cancers. The purposes of this study were to analyze the distribution characteristics of colorectal cancer patients regarding gender, age, location and tumor size in the course of colonoscopy. Materials and Methods: All colorectal cancer patients who underwent colonoscopy in the First Affiliated Hospital of Guangxi Medical University from 2003 to 2012 were included in our retrospective study. Demographic information (age and gender) and colonoscopy report information (tumor size and location) were collected and analyzed. To compare the gender differences in tumor location and tumor size, as well as the size differences in tumor location, the chi-square test was used. Results: A total of 3, 369 colorectal cancer patients (2, 007 men vs 1, 362 women) were included in our study. Statistical analysis showed there was no gender difference in the anatomic distribution of the tumors (p>0.05). However, there was a gender difference in tumor size (p<0.05). In addition, our study found there was a significant difference in tumor size between rectal and colon tumors (p<0.001). Conclusions: There was no gender difference in the anatomic distribution of colorectal tumors. In addition, tumors observed in men were larger than in women.

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Descriptive Epidemiology of Colorectal Cancer in University Malaya Medical Centre, 2001 to 2010

Cited by 23 publications

References 19 publications

Demographic Survey of Four Thousand Patients with 10 Common Cancers in North Eastern Iran over the Past Three Decades

Demographic Survey of Four Thousand Patients with 10 Common Cancers in North Eastern Iran over the Past Three Decades

Survival rates and predictors of survival among colorectal cancer patients in a Malaysian tertiary hospital

Distribution Characteristics of 3,369 Chinese Colorectal Cancer Patients for Gender, Age, Location and Tumor Size During Colonoscopy

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