Outcome of Rectal Cancer in Patients Aged 30 Years or Less in the Pakistani Population

Ali, Akbar; Bhatti, Abu Bakar Hafeez; Khattak, Shahid; Syed, Aamir Ali; Kazmi, Ather; Jamshed, A.

doi:10.7314/apjcp.2014.15.15.6339

Cited by 6 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding that CRC is the commonest GI cancer among YIs is supported by similar results found in other parts of the world including developed countries like United States, Europe, Canada, Australia and New Zealand where a sharp rise in such cases has been demonstrated 2‐7 . In Pakistan too, this trend has been noted in earlier studies and emphasis has been laid upon need for further research work and early age of screening to detect rectal cancers 15‐17 . A significant proportion of our patients with rectal cancers exhibited signet ring cell histology (SRCH).…”

Section: Discussionsupporting

confidence: 87%

“… 2 , 3 , 4 , 5 , 6 , 7 In Pakistan too, this trend has been noted in earlier studies and emphasis has been laid upon need for further research work and early age of screening to detect rectal cancers. 15 , 16 , 17 A significant proportion of our patients with rectal cancers exhibited signet ring cell histology (SRCH). Various studies done elsewhere in the world show that SRCH is more common in young than in old patients and may represent more advanced stage at presentation and worse prognosis compared with mucinous and non‐mucinous rectal adenocarcinomas.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors

Tasneem

Luck

2020

Cancer Reports

View full text Add to dashboard Cite

Background Digestive tract neoplasms (DTN) have become increasingly common worldwide among young individuals (YIs) over the last few decades. Aim Aim of this research was to study the types, demographics, stage at presentation and risk factors of digestive tract neoplasms in young individuals. Methods and results In this cross‐sectional study, YI (ie, ≤40 years) presenting with any DTN including gastrointestinal neoplasms (GIN), hepatobiliary neoplasms (HBN), periampullary neoplasms (PAN) and others from June 2016 to May 2020 were included. Baseline laboratory tests, tissue diagnosis and staging were performed while risk factors were documented. A total of 163 patients were included in the study, of whom 82 (50.3%) were males. Mean age was 29.9 (±9.57) (range: 8 months‐40 years). Most DTN (93.3%; n = 152) were malignant. The commonest neoplasms were lower GIN (LGIN) 52 (31.9%), followed by HBN 46 (28.2%), upper GIN (UGIN) 44 (27%) and PAN 18 (11%). Commonest among LGIN were rectal 37; among HBN: hepatocellular cancer (HCC) 9, cholangiocarcinoma (CC) 9; and among UGIN: esophageal 25 and stomach 14. Rectal cancers were mostly sporadic (82.7%) with frequent signet ring cell histology (40.5%), and affected relatively younger ages compared to upper GIN and PAN. GIN were mostly locally advanced with higher resectability (LGIN 90.4%; UGIN 79.5%) while HBN were more advanced with lower resectability (HCC [44.4%]; CC [33.3%]). Poor dietary habits and poor socioeconomic status were common with UGIN (63.6%, 50%) and HBN (56.5%, 54.3%), respectively. Conclusion The commonest DTN among YI were LGIN followed by HBN, UGIN and PAN. Rectal cancers affected relatively younger ages and were mostly sporadic. HBN were more advanced in stage and unresectable compared to GIN. Poor dietary habits and poor socioeconomic status may be important contributors in carcinogenesis.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 95%

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors

Tasneem

Luck

2020

Cancer Reports

View full text Add to dashboard Cite

show abstract

“…Associated work up and planning has been discussed elsewhere (Akbar et al, 2014). The standard protocol was to administer preoperative CRT in T3/T4 and/or clinically node positive tumors.…”

Section: Methodsmentioning

confidence: 99%

Impact of Time Interval Between Chemoradiation and Surgery on Pathological Complete Response and Survival in Rectal Cancer

Ali¹,

Bhatti²,

Niazi³

et al. 2016

Asian Pacific Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

Background: Limited data are available regarding the impact of time duration between chemoradiation (CRT) and surgery on pathological complete response (PCR). A PCR translates into better overall and disease free survival. The objective of this study was to determine effect of time duration on outcome after preoperative CRT in rectal cancer. Materials and Methods: A retrospective review of patients undergoing operations for rectal adenocarcinoma between January 2005 and December 2010 was performed. Patients were divided in two groups: Group 1 underwent surgery in ≤ 8weeks post neoadjuvant CRT and Group 2 after 8 weeks. Patient characteristics, surgical procedure, histopathological details and number of loco-regional and distant failures were compared. Expected 5 year overall survival and disease free survival was calculated using Kaplan Meier curves and significance was determined using the log rank test. Results: There were 66 patients in group 1 and 93 in group 2. No significant difference in PCR was observed between the two. However, estimated 5 year DFS was significantly higher in Group 1 (66.7%) as compared to Group 2 (53.8%) (P=0.04). Estimated overall 5 year overall survival was not significantly different at 68.2% versus 54.3% (P= 0.09). Conclusions: Delaying surgery more than 8 weeks after preoperative CRT does not impact for PCR in rectal cancer.

show abstract

“…A few sporadic studies have emerged over the years suggesting this fact. In a small series, this percentage was reported to be 26.3% in rectal carcinoma patients below 30 years of age group [11]. Another study reported the ratio of under age 40 to over age 40 patients in colorectal cancer to be 0.3 [12].…”

Section: Introductionmentioning

confidence: 99%

Rectal Carcinoma: Demographics and Clinicopathological Features from Pakistani Population Perspective

Pirzada

Ahmed

Muzzafar

et al. 2017

Cureus

Self Cite

View full text Add to dashboard Cite

BackgroundColorectal carcinoma is ranked as the second most common cancer diagnosis in females and third in males. It is the third leading cause of cancer-related deaths worldwide. Disease burden has been attributed to a myriad of factors comprising genetic, environmental, and dietary factors. Rectal cancer has been shown to demonstrate variance according to the geographical location.MethodsA retrospective review of 477 rectal cancer patients treated at Shaukat Khanum Memorial Cancer Hospital & Research Centre from 2006 to 2014 was performed. Demographic and clinicopathological features were compared between the two age groups (≤40 or >40 years). These included sex, ethnicity, family history of cancer, the location of tumor, clinical staging, histopathological type, and response to chemoradiation. Chi-square was used to compare the frequencies between the two age groups. p-value < 0.05 was taken as significant.ResultsMean age of the study group was 44.62 ± 16.11 years. 43.8% were ≤40 years of age, and 70.2% were male. 50.3% patients belong to Punjab province, 287 (60.2%) had lower rectal cancer, family history of cancer was present in 82 (17.2%) patients. 432 (90.5%) patients had T1/T2 disease and 296 (62.1%) had N2 disease. Metastatic disease at presentation was observed in 37 (7.8%). Progressive disease was found in 90 (18%) patients.ConclusionHigh frequency of young onset rectal cancers and the lack of family history emphasize the need of indigenous strategies and national awareness of this disease for an early identification of these patients.

show abstract

Outcome of Rectal Cancer in Patients Aged 30 Years or Less in the Pakistani Population

Cited by 6 publications

References 20 publications

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors

Impact of Time Interval Between Chemoradiation and Surgery on Pathological Complete Response and Survival in Rectal Cancer

Rectal Carcinoma: Demographics and Clinicopathological Features from Pakistani Population Perspective

Contact Info

Product

Resources

About