Pathways of nicotinamide adenine dinucleotide biosynthesis in nicotinic acid or nicotinamide requiring microorganisms

Ohtsu, Eiji; Ichiyama, Arata; Nishizuka, Yasutomi; Hayaishi, Osamu

doi:10.1016/0006-291x(67)90263-x

Cited by 19 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two distinct pathways, one of which utilizes nicotinic acid and the other nicotinamide, are known in biological systems for the synthesis of nicotinamide adenine dinucleotide (NAD) from the vitamin; the two biosynthetic routes feature no common intermediates (5). Several organisms employ exclusively the nicotinic acid pathway and can use nicotinamide only after deamidating it through the action of the enzyme nicotinamide deamidase (nicotinamide amidohydrolase).…”

mentioning

confidence: 99%

Chromosomal Location of a Gene Defining Nicotinamide Deamidase in Escherichia coli

Dickinson

Sundaram

1970

J Bacteriol

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Chromosomal Location of a Gene Defining Nicotinamide Deamidase in Escherichia coli

Dickinson

Sundaram

1970

J Bacteriol

View full text Add to dashboard Cite

show abstract

“…High activities were also present in baker's yeast and Pseudomonas riboflavina. On the other hand, the enzyme activity was not detected in Lactobacillus which require nicotinic acid or nicotinamide for the growth, due to the lack of de novo pathway of NAD (21).…”

Section: Discussionmentioning

confidence: 92%

Distribution of Quinolinate Phosphoribosyl-Transferase in Animals, Plants and Microorganisms

Iwai¹,

Taguchi²

1973

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

“…These authors concluded that H . haemoglobinophilus lacks the de novo and Preiss-Handler pathways for NAD biosynthesis and uses instead the nicotinamide pathway described for Lactobacillus fructosus (30). In effect, H. haemoglobinophilus requires a pyridine nucleotide precursor for growth, and this requirement can be satisfied by NAm (23).…”

Section: Haemophilus: Requirements For Pyridine Nucleotides or Precurmentioning

confidence: 99%

Significance of V-Factor Dependency in the Taxonomy of Haemophilus Species and Related Organisms

Niven

O’Reilly

1990

International Journal of Systematic Bacteriology

View full text Add to dashboard Cite

The family Pasteurellaceae comprises the genera Huemophilus, Pasteurella, and Actinobacillus (22). These three genera are closely related, with Pasteurella and Actinobacillus being particularly ditficult to differentiate (3,24,27,33,40,41); such difficulties have led to the suggestion that the genera Pasteurella and Actinobacillus should be combined to form one genus (40,41). On the other hand, organisms of the genus Haemophilus have been distinguished, traditionally, by their requirement for X factor or V factor or both (15). Recently, however, the results from DNA homology studies (35) have been used to challenge the use of V-factor requirement as a generic criterion (21,35), and in subsequent studies (36), Haemophilus pleuropneumoniae, which requires V factor (16), and the closely related Pasteurella haemolytica-like organism of Bertschinger and Seifert (H. U. Bertschinger and P. Seifert, Abstr. 5th Int. Pig Vet. SOC. World Cong. Hyol. Hyiatr., abstr. no. M19, 1978) were transferred to the genus Actinobacillus as Actinobacillus pleuropneumoniae biotypes 1 and 2, respectively. There have also been suggestions and proposals for the transfer of organisms from the genus Haemophilus to the genus Pasteurella (26) and from the genus Actinobacillus to the genus Haemophilus (5, 14, 37, 38), as well as for the transfer of organisms from the genus Pasteurella to the genus Actinobacillus (7, 9,24,25,28,35). Indeed, it now appears to be generally accepted that genera belonging to the family Pasteurellaceae may comprise both V-factor-requiring and Vfactor-nonrequiring species (10).While the information described above suggests that the taxonomic significance of V-factor requirement or V-factor dependency has been overemphasized in the past, it is our contention that such a conclusion may be inappropriate as it relies on a somewhat superficial interpretation of the data. To lend credence to this view, the aims of this paper are to review, briefly, the nature of V factor and the biochemical basis for V-factor dependency and to present evidence suggesting that under appropriate conditions, V-factor-dependent growth may be a characteristic exhibited by all members of the family Pasteurellaceae, suggesting in turn that all of these organisms may be incapable of synthesizing V factor de novo. The available information also suggests that of the pyridine compounds involved in procaryotic pyridine nucleotide metabolism (8,23,48), only a few specific pyridine nucleotides and precursors can support the growth of these organisms. Such a feature may help to consolidate the family Pasteurellaceae and may prove to be useful in future decisions regarding the placement of organisms such as Haemophilus ducreyi, Haemophilus somnus, * Corresponding author. and other related organisms, whose taxonomic positions remain somewhat uncertain (2, 4,34,42). HAEMOPHILUS: REQUIREMENTS FOR PYRIDINE NUCLEOTIDES OR PRECURSORS AND REASONSFOR SUCH REQUIREMENTS Collectively, the results of several studies have demonstrated that NAD, nicotinamide mononucleot...

show abstract

Pathways of nicotinamide adenine dinucleotide biosynthesis in nicotinic acid or nicotinamide requiring microorganisms

Cited by 19 publications

References 6 publications

Chromosomal Location of a Gene Defining Nicotinamide Deamidase in Escherichia coli

Chromosomal Location of a Gene Defining Nicotinamide Deamidase in Escherichia coli

Distribution of Quinolinate Phosphoribosyl-Transferase in Animals, Plants and Microorganisms

Significance of V-Factor Dependency in the Taxonomy of Haemophilus Species and Related Organisms

Contact Info

Product

Resources

About