Pathologic changes in pig organs, infected with the Aujeszkys disease

Ukhovskyi, V. V.; Romanov, O.M.; Борисевич, Б В

doi:10.15421/2020_199

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…However, it was found that the dosage form and manufacturing technology of drugs are also essential and their physical state, the properties of the constituent components, and the route of administration into the body (Pink et al, 2005;Mukherjee et al, 2016). The study of their toxic effects on biological objects is an intermediate stage in testing new chemical compounds (Bondarchuk et al, 2019;Orobchenko et al, 2020;Kovalenko et al, 2020). The research aim was to estimate the suggested innovative complex veterinary drugs.…”

Section: Effectiveness Of a Modern Antiparasitic Agentmentioning

confidence: 99%

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Paliy¹,

Петров²,

Kovalenko³

et al. 2021

Ukr J Ecol

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Parasitic diseases continue to account for a significant proportion of overall morbidity in many parts of the world despite improved living conditions and increased awareness of health issues. The creation of innovative veterinary antiparasitic agents is a promising area of modern veterinary pharmacy. The pathogens Dipylidium caninum, Ancylostoma caninum, Toxocara canis, Toxocaris leonina were identified in the study of stray dogs (n=12). Eggs of Dipylidium caninum, Toxocara mystax, and Toxocaris leonina were found during cats' examination (n=15). Both mono and mixed invasions have been diagnosed in animals. We established that the floor and inventory were contaminated with exogenous forms of helminths at an extent of 100% after keeping animals in the shelter's enclosures. An innovative antiparasitic agent was used to treat animals. One tablet (0.5 g) contains the following active ingredients such as pyrantel pamoate (150±0.5 mg), praziquantel (50±0.5 mg), and auxiliary substances (lactose, microcrystalline cellulose, calcium stearate, sodium chloride, food flavoring "meat", povidone K-30 and potato starch). We estimated high antiparasitic agents' extensive efficiency (100%) at mono and mixed invasions in dogs and cats.

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Section: Effectiveness Of a Modern Antiparasitic Agentmentioning

confidence: 99%

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Paliy¹,

Петров²,

Kovalenko³

et al. 2021

Ukr J Ecol

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“…У даний час фармацевтична галузь постійно працює над створенням ідеальних дезінфікуючих засобів, які б володіли широким спектром антимікробної дії у мінімальних концентраціях, не спричиняли формування стійкості у бактерій, були не токсичними, не корозійними, не алергенними, дешевими, тощо (Palii et al, 2020;Kovalenko et al, 2020). Для цього використовуються та поєднаються між собою дезінфікуючі субстанції із різних груп, дія яких направлена на пригнічення активності різних ферментних систем бактеріальної клітини та руйнування її структурних елементів (Augustin et al, 2004;Kovalenko et al, 2018).…”

Section: вступunclassified

“…Наявність мікробних біоплівок на поверхнях медичних інструментів, операційному обладнанні, протезах, катетерах, технологічних лініях у харчовій промисловості вважається чинником, який сприяє інфікуванню макроорганізму, забрудненню сировини та продукції (Hoque et al, 2015;Kukhtyn et al, 2017;Berhilevych et al, 2017). Тому використання біоцидів направлене на знищення планктонних і біоплівкових форм мікроорганізмів на різних поверхнях (Augustin et al, 2004;Kovalenko et al, 2018;Palii et al, 2020). Однак успішна боротьба з мікроорганізмами, які перебувають у біоплівках, можлива за умови застосування дезінфікуючих засобів, які руйнують екзополісахаридний матрикс і сприяють тіснішому контакту бактерій з біоцидом (Lequette et al, 2010).…”

Section: обговоренняunclassified

The activity of the disinfectant “Enzidez” against bacteria in biofilms

et al. 2021

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Currently, the pharmaceutical industry is constantly working on the creation of ideal disinfectants that would have a wide spectrum of antimicrobial action in minimal concentrations, did not result in the formation of stability in bacteria, were not toxic, not corrosive, not allergenic, cheap. The purpose of the work was to investigate the activity of the “Enzidesis” disidissance to influence microbial biofilms in vitro conditions for various sampling parameters. The density of microbial biofilms and the effects of disinfectants were determined on sterile stainless steel plates, which were placed in a Petri dish. For this purpose, biofilms were grown on plates, washed out biofilms from planktonic cells, acted as a disguise for a certain concentration and for a period of 5–30 minutes, fixed and painted biofilms and determined the optical density of the flushing solution from biofilms spectrometrically. It has been established that the disinfectant “Enzidesis” destroys the biofilms taken in the experiment of museum test cultures S. aureus, E. coli and P. aeruginosa. In particular, for the influence of the lowest concentration in experiment, 0.075 % optical density of washing solutions from S. aureus biofilmes decreased by 2.6 times, E. coli and P. aeruginosa biofilm in 2.9 times, respectively, comparing with biofilms after treatment with water. Under the actions of such a concentration of the “Enzidesis” means, the biofilm though significantly degraded, but they were still a medium density, more than 0.5 units. Increasing the concentration of a means of 0.075 % to 0.5 % contributed to the intensity of degradation of test-cultures, an average of 3.0 times (P < 0.05) and they became a weak density (0.24–0.20 s). Increasing the concentration of the “Enzidesis” means up to 1.0 % or more, did not significantly destroy the matrix of the biofilm of microorganisms, since the optical density of the washing solutions was as in control. In determining the influence of the temperature of the working solutions of the “Enzidosis” means on its film-building activity, it has been found that with an increase in the disinfection agent “Enzidesis” with +20 to +60 °С there is an increase in the degradation of the biofilm formed S. aureus, E. coli and P. aeruginosa. Dezilities can be effectively used in 0.5 % concentration at room temperature of solutions. When substantiating the exposure time of the “Enzidesis” exhibition time, it has been found that to remove the S. aureus, E. coli and P. aeruginosa 0.5 % means at a solution temperature of +20 ± 1 °C, it is necessary that the action time is from 15 to 30 minutes.

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Efficiency of “Biolide” disinfectant working solutions for action on gram-negative and gram-positive bacteria

Chechet¹,

Kovalenko²,

Garkavenko³

et al. 2021

Bìol. Tvarin

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The article presents the results of the new developed disinfectant “Biolide” research for use in poultry and other sectors of agriculture, because today the problem of developing cheap and effective disinfectants remains relevant. In recent years, the poultry industry has a tendency to rapid development, since the population’s demands for poultry products have increased markedly. With an integrated approach to the production of chicken meat, it is possible to increase the productivity of poultry enterprises, energy efficiency and reduce the cost of production. When applying such an integrated approach, one of the important roles is played by the provision of high-quality disinfection with effective and inexpensive means. In connection with the relevance of the development of new effective disinfectants, the main purpose of the research was to determine the effectiveness of working solutions in concentrations of 0.1; 0.2; 0.25 and 0.5% for gram-negative E. coli ATCC 25922 and gram-positive S. aureus ATCC 25923 for different periods of time — 20, 30, 60 and 120 min. after the simulation of protein contamination. Test cultures E. coli ATCC 25922 and S. aureus ATCC 25923 in lyophilized form were stored in a refrigerator at a temperature –70±5°C. By replacing them on nutrient media, metabolic processes were restored and their correspondence to the main typical properties for this type of pathogens was checked. Simulation of protein contamination was carried out using sterile inactivated blood serum of cattle in the amount of 40.0% to the volume of the used bacterial suspension. In laboratory tests, smooth surfaces of tiles with an area 100 cm2 were used as test objects. The analysis of the obtained research results showed the high efficiency of 0.5% working solutions of the new disinfectant “Biolide” when exposed to test cultures E. coli ATCC 25922 and S. aureus ATCC 25923 for 60 min., since this concentration of the working disinfectant solution and the exposure time ensured the destruction by 99.99–100.0% of gram-negative and gram-positive microorganisms when imitating protein contamination of test objects.

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Pathologic changes in pig organs, infected with the Aujeszkys disease

Cited by 4 publications

References 19 publications

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

Effectiveness of a modern antiparasitic agent for deworming in domestic animals

The activity of the disinfectant “Enzidez” against bacteria in biofilms

Efficiency of “Biolide” disinfectant working solutions for action on gram-negative and gram-positive bacteria

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