Paternal and maternal age at pregnancy and autism spectrum disorders in offspring

Budi, Luh Putu Rihayani; Sitaresmi, Mei Neni; Windiani, I Gusti Ayu Trisna

doi:10.14238/pi55.6.2015.10

Cited by 7 publications

(9 citation statements)

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“…Idring et al evaluated 417,303 Swedish children and showed a direct correlation between ASD and paternal age [58]. The risk of ASD is 6.3 times more in offspring of older fathers (≥40 years) compared to younger fathers [15].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei

Litzky

Esfandiari

2020

Reprod Biol Endocrinol

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Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations. This increased average paternal age has led to concerns about adverse effects of advanced paternal age on sperm quality, assisted reproductive outcomes, and the health of the offspring conceived by older fathers. This review discusses the association between advanced paternal age and sperm parameters, assisted reproduction success rates, and offspring health.

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Section: Psychiatric Disordersmentioning

confidence: 99%

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei

Litzky

Esfandiari

2020

Reprod Biol Endocrinol

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“…Na perspectiva de estimar razão de chances (OR) = 1,9 26,34 e probabilidade 0,18 de exposição entre os controles 38 , planejou-se o cálculo do tamanho amostral para estudo de caso e controle independente 39 . Neste estudo, estava prevista análise de vários fatores de exposição, então, considerou-se valores referentes ao fator de exposição idade materna no parto ≥ 35 anos, por ter fornecido o maior tamanho amostral dentre os demais testados (sexo masculino, idade materna e idade paterna).…”

Section: Tamanho Amostralunclassified

“…Entretanto, os resultados são inconsistentes, apesar das meta-análises publicadas sobre a idade do pai 17 , a idade da mãe 18 e ambas as idades 19 . Alguns trabalhos apontam ainda que tanto a idade paterna quanto a materna 14,15,16,20,21,22,23,24,25,26,27,28 , apenas a idade paterna 17,29,30,31,32,33,34 , ou apenas a idade materna 35,36 são consideradas fatores de risco para o TEA. Além disso, Larsson et al 37 não encontraram associação entre a idade dos genitores e o TEA.…”

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Transtorno do espectro do autismo e idade dos genitores: estudo de caso-controle no Brasil

et al. 2018

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Autism spectrum disorder (ASD) has become a public health problem with major family, social, and economic impacts. This study aimed to estimate the association between ASD and parents' age at the time of their child's birth. A case-control study was performed, consisting of 243 individuals with ASD (cases) and 886 neurotypical controls. A semi-structured questionnaire was applied, following by multiple logistic regression. Associations between ASD and paternal age (in years) from 25 to 34 (OR = 1.65; 95%CI: 1.01-2.71), 35 to 44 (OR = 1.62; 95%CI: 0.96-2.73), and ≥ 45 (OR = 2.44; 95%CI: 1.14-5.00); and maternal age from 25 to 34 (OR = 2.38; 95%CI: 1.54-3.37) and ≥ 35 (OR = 2.09; 95%CI: 1.29-3.39) were significant when assessed in independent models. However, when included in a single model, only maternal age from 25 to 34 (OR = 2.27; 95%CI: 1.45-3.55) and ≥ 35 years (OR = 2.15; 95%CI: 1.21-3.83) remained associated with ASD. The association was stronger when both parents were older (OR = 4.87; 95%CI: 1.71-13.80). The results have important implications for clinical psychiatry and public health, since parents' age at childbirth has increased. Emphasis is needed on the prevention of late childbearing and screening and follow-up of children born to these couples.

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“…This study is in line with the results of Arulita's (2014) study that there was no relationship between mother aged ≥ 35 years during pregnancy with the incidence of ASD (p = 1.000). The results of a study conducted by Budi (2015) showed similarities that mother aged ≥ 35 years during pregnancy did not have a significant relationship to the incidence of ASD (p = 0.261). Although the result of the study showed no significant relationship to the incidence of ASD, the age of pregnant mother of ≥ 35 years old is a high-risk gestational age.…”

Section: Resultsmentioning

confidence: 96%

Risk Factors of Autism Spectrum Disorder (ASD)

Hernawan

Diningrum

Jati

et al. 2018

UJPH

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Abstract There were 112,000 ASD sufferers in Indonesia in 2012 and in 2015 it was estimated that there were 1 per 250 children or 134,000 sufferers. The proportion of ASD was 62.8% and in 2016 it was 1.28 out of 1000 children in 2015. This study aimed to determine the risk factors for the incidence of ASD in Pontianak City. The research method was analytic observational with a control case study design. The sample was 70 people (35 cases and 35 controls) taken by purposive sampling technique. Data analysis used Chi-Square test (α = 0,05). The results showed that the factors associated with the incidence of ASD were father's age (p = 0.03; OR = 4.00; CI = 1.250-12.804), stress history during pregnancy (p = 0.04; OR = 3.18; CI = 1.13-8.93) and insufficient months of birth (p = 0.036; OR = 4.88; CI = 1.22-19.4), while age of mother during pregnancy, passive smoker, antenatal hemorrhage and pregnancy interval were not associated with the incidence of ASD (p> 0.05). The conclusion of this study is father's age, the presence of a history of stress during pregnancy and insufficient months of birth associated with the incidence of ASD. Keywords: Father’s age, Stress History, Autism Spectrum Disorder Abstrak Autism Spectrum Disorder (ASD) dikenal sebagai triad of impairments yaitu adanya gangguan perkembangan pada aspek komunikasi, adanya perilaku yang diulang-ulang dan gangguan dalam berinteraksi dengan lingkungan. Pada tahun 2012 dilaporkan sebanyak 112.000 penderita ASD di Indonesia, tahun 2015 diperkirakan terdapat 1 per 250 anak atau 134.000 penderita. Data dari UPTD Autis Center Kota Pontianak tahun 2015 proporsi ASD sebesar 62,8% dan pada tahun 2016 sebesar 1,28 dari 1000 anak. Penelitian ini bertujuan untuk mengetahui faktor risiko kejadian ASD di Kota Pontianak. Metode penelitian adalah observasional analitik dengan desain studi kasus kontrol.Sampel penelitian berjumlah 70 orang (35 kasus dan 35 kontrol) yang diambil dengan teknik purposive sampling. Analisis data menggunakan uji Chi-Square (α=0,05). Hasil penelitian menunjukkan faktor yang berhubungan dengan kejadian ASD adalah usia ayah (p=0,03; OR=4,00; CI=1,250-12,804), riwayat stres saat hamil (p=0,04; OR=3,18; CI=1,13-8,93) dan lahir belum cukup bulan (p=0,036; OR=4,88; CI=1,22-19,4), sedangkan usia ibu saat hamil, perokok pasif, perdarahan antenatal dan jarak kehamilan tidak berhubungan dengan kejadian ASD (p>0,05). Simpulan penelitian ini adalah faktor usia ayah, adanya riwayat stres saat hamil dan kelahiran belum cukup bulan berhubungan dengan kejadian ASD. Keyword : Usia ayah, riwayat stress, Autism Spectrum Disorder

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Paternal and maternal age at pregnancy and autism spectrum disorders in offspring

Cited by 7 publications

References 0 publications

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Transtorno do espectro do autismo e idade dos genitores: estudo de caso-controle no Brasil

Risk Factors of Autism Spectrum Disorder (ASD)

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