Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei, Iman; Litzky, Julia F.; Esfandiari, Navid

doi:10.1186/s12958-020-00668-y

Cited by 59 publications

(52 citation statements)

References 127 publications

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“…of embryos and pregnancy rates were all significantly higher in younger group of patients. Many studies were in agree with this results (12,15,18,19,20,21,22) . On the other hand, the level of basal serum FSH was higher in older women group but still the difference was not significant may be due to the minimum differences in the age of the individuals between both groups.…”

Section: Discussionsupporting

confidence: 70%

How Can the Maternal Age and the Basal Level of Serum FSH Predict the ICSI Outcome?

Maher Abbood Mukheef,

Rihab Abbas Ali,

Hind Hadi Majeed

2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Age is an important factor affect female fertility, it is important to consider it while planning for intracytoplasmic sperm injection (ICSI). Basal follicular stimulating hormone(FSH) level can be an indicator of the ovarian reserve as the high level is associate with poor ovarian reserve and subsequently poor intracytoplasmic sperm injection outcome.Objective: we aimed in this study to emphasize the role of age and basal serumfollicular stimulating hormone level in predicting the intracytoplasmic sperm injection outcome.Patients and Method:a sixty sub-fertile couple were involved in this study. They were divided into two groups according to the age of female partner. Group 1 ≤35 years old and group 2 >35 years old. We compared the difference in the basal follicular stimulating hormone level and theintracytoplasmic sperm injection outcome. Then we studied the association between the basal follicular stimulating hormone level and the intracytoplasmic sperm injection outcome.Results: the study revealed that female ≤35 resulted in significantly better the intracytoplasmic sperm injection outcome.The no. of follicles, the no. of collected oocytes, no. of injected metaphase II oocytes (MII), no. of two pronuclei (2PN), total no. of embryos and no. of transferred embryos all were significantly higher in younger patients (P-value <0.05. The pregnancy rate was significantly higher in younger age group (47.5 % vs 25%, P-value = 0.04). there was a negative association between the basal follicular stimulating hormone level and the no. of follicles and no. of oocytes. Conclusion:Maternal age is a good indicator for the success of the intracytoplasmic sperm injectionprocedure. The younger the female partner the better the intracytoplasmic sperm injection outcome. Basal level of follicular stimulating hormone is closely related to the ovarian reserve and subsequently the intracytoplasmic sperm injection outcome.

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Section: Discussionsupporting

confidence: 70%

How Can the Maternal Age and the Basal Level of Serum FSH Predict the ICSI Outcome?

Maher Abbood Mukheef,

Rihab Abbas Ali,

Hind Hadi Majeed

2021

Indian Journal of Forensic Medicine & Toxicology

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“…As sperm are proficient generators of ROS, they are only left with their poorly functioning antioxidant defenses (SOD, GPX and catalase) to combat oxidative damage [25,26]. This, coupled with aging, which is already associated with its own reduced antioxidant defenses [27], adds further insult to the already poorly defended sperm.…”

Section: Introductionmentioning

confidence: 99%

Improving Sperm Oxidative Stress and Embryo Quality in Advanced Paternal Age Using Idebenone In Vitro—A Proof-of-Concept Study

2021

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Advanced paternal age is associated with increased sperm reactive oxygen species (ROS) and decreased fertilization and pregnancy rates. Sperm washing during infertility treatment provides an opportunity to reduce high sperm ROS concentrations associated with advanced paternal age through the addition of idebenone. Sperm from men aged >40 years and older CBAF1 mice (12–18 months), were treated with 5 µM and 50 µM of idebenone and intracellular and superoxide ROS concentrations assessed. Following in vitro fertilization (IVF), embryo development, blastocyst differentiation, DNA damage and cryosurvival, pregnancy and implantation rates and fetal and placental weights were assessed. Five µM of idebenone given to aged human and mouse sperm reduced superoxide concentrations ~20% (p < 0.05), while both 5 and 50 µM reduced sperm intracellular ROS concentrations in mice ~30% (p < 0.05). Following IVF, 5 µM of idebenone to aged sperm increased fertilization rates (65% vs. 60%, p < 0.05), blastocyst total, trophectoderm and inner cell mass cell numbers (73 vs. 66, 53 vs. 47 and 27 vs. 24, respectively, p < 0.01). Treatment with idebenone also increased blastocyst cryosurvival rates (96% vs. 78%, p < 0.01) and implantation rates following embryo transfer (35% vs. 18%, p < 0.01). Placental weights were smaller (107 mg vs. 138 mg, p < 0.05), resulting in a larger fetal to placental weight ratio (8.3 vs. 6.3, p = 0.07) after sperm idebenone treatment. Increased sperm ROS concentrations associated with advanced paternal age are reduced with the addition of idebenone in vitro, and are associated with improved fertilization rates, embryo quality and implantation rates after IVF.

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“…As a high male age is associated with poor semen parameters and higher SDF [ 38 ], we compared the effects of DGC and SU on the outcomes of cycles when using sperm from different male age groups. We found that all of the outcomes were similar between the DGC and SU groups for all age groups (Additional Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Cumulative live birth rates after IVF/ICSI cycles with sperm prepared by density gradient centrifugation vs. swim-up: a retrospective study using a propensity score-matching analysis

Rao

Wang

et al. 2022

Reprod Biol Endocrinol

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Background Density gradient centrifugation (DGC) and swim-up (SU) are the two most widely used sperm preparation methods for in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). However, existing comparisons of IVF/ICSI outcomes following these sperm preparation methods are insufficient and controversial. Methods This retrospective study included all first autologous IVF and ICSI cycles performed between March 1, 2016, and December 31, 2020 in a single university-based center. A total of 3608 cycles were matched between DGC and SU using propensity score (PS) matching for potential confounding factors at a ratio of 1:1. The primary outcome was the cumulative live birth rate (cLBR) per aspiration. Results PS matching provided 719 cycles after DGC and 719 cycles after SU. After adjusting for confounders, the recovery rate, progressive motility rate after sperm preparation, fertilization rate, good-quality embryo rate, and blastocyst formation rate were similar between the DGC and SU groups. The cLBR (odds ratio [OR] = 1.143, 95% confidence interval [CI]: 0.893–1.461) and LBR per transfer (OR = 1.082, 95% CI: 0.896–1.307) were also not significantly different between the groups. Furthermore, no significant differences were found in all of the laboratory and clinical outcomes following conventional IVF or ICSI cycles between the two groups. However, a significantly higher fertilization rate (β = 0.074, 95% CI: 0.008–0.140) was observed when using poor-quality sperm in the DGC group than in the SU group. Conclusions Sperm preparation using DGC and SU separately resulted in similar IVF/ICSI outcomes. Further studies are warranted to compare the effects of these methods on IVF/ICSI outcomes when using sperm from subgroups of different quality.

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Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Cited by 59 publications

References 127 publications

How Can the Maternal Age and the Basal Level of Serum FSH Predict the ICSI Outcome?

How Can the Maternal Age and the Basal Level of Serum FSH Predict the ICSI Outcome?

Improving Sperm Oxidative Stress and Embryo Quality in Advanced Paternal Age Using Idebenone In Vitro—A Proof-of-Concept Study

Cumulative live birth rates after IVF/ICSI cycles with sperm prepared by density gradient centrifugation vs. swim-up: a retrospective study using a propensity score-matching analysis

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