Parotid acinic cell carcinoma with undifferentiated spindle cell transformation

Ferreiro, Jorge A.; Kochar, Amarjit S.

doi:10.1017/s0022215100128464

Cited by 13 publications

(4 citation statements)

References 17 publications

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“…[37][38][39] Non-radiation-related "dedifferentiation" of salivary gland tumors is also an uncommon phenomenon. 40,41 Whether histologic progression in the 2 cases we report was related to treatment with radiation is unclear. Recurrent disease has not developed in most patients with PLGA who are receiving radiation therapy.…”

Section: Casementioning

confidence: 93%

Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

Pelkey

Mills

1999

Am J Clin Pathol

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Section: Casementioning

confidence: 93%

Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

Pelkey

Mills

1999

Am J Clin Pathol

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“…Its biphasic appearance and nondescript sarcomatous morphology are obvious and fairly readily diagnosed as overtly malignant. Little has been published on this diagnostically challenging lesion [22,24], but sarcomatoid change has been documented in various distinct types of salivary gland carcinoma, including mucoepidermoid carcinoma [14], acinic cell carcinoma [4], adenoid cystic carcinoma [3], squamous cell carcinoma [9,13], epithelial-myoepithelial carcinoma [15], undifferentiated carcinoma [2,7] and salivary duct carcinoma (SDC) [8,19]. In all likelihood, no particular histological subtype has a predilection for sarcomatoid differentiation.…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid salivary duct carcinoma of the oral cavity

2003

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This report recounts a new case of sarcomatoid variant of salivary duct carcinoma in a 45-year-old woman. The 1.5-cm polypoid mass protruded from the retromolar area and focally extended into the pharyngeal wall. The patient was free of disease for 11 years. The tumor showed a biphasic malignancy; nondescript sarcomatous proliferation predominated over ductal carcinoma population, with perceptible blending of the two components. The sarcomatoid areas had no heterologous properties. Discohesive pleomorphic cells were immunopositive for vimentin, epithelial membrane antigen and AE1/AE3 at a significant rate. A dual expression of AE1/AE3 and vimentin was also evident in enmeshed foci of conventional cribriform adenocarcinoma. Thus, the sarcomatoid histology represents a dedifferentiated phenotype of salivary duct carcinoma.

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“…25,26,31,32 Although the term carcinosarcoma is widely used for biphasic carcinomatous and mesenchymal neoplasms in the field of salivary gland pathology, we recommend the term sarcomatoid variant of SDC (sarcomatoid SDC) instead of carcinosarcoma when the carcinomatous component of those lesions is SDC and the term sarcomatoid carcinoma, NOS for lesions in which the carcinoma component is not a distinct type of tumor. Rarely, sarcomatoid features also have been described in other distinct types of salivary gland carcinoma, including mucoepidermoid carcinoma, 33 acinic cell carcinoma, 34 squamous cell carcinoma, 35,36 and epithelial-myoepithelial carcinoma. 37 Because metaplasia, by definition, is a reversible change in which one adult cell type is replaced by another adult cell type, 38 we believe that metaplastic carcinoma is an inappropriate term to designate biphasic carcinomatous and mesenchymal neoplasms.…”

Section: Discussionmentioning

confidence: 97%

Sarcomatoid Variant of Salivary Duct Carcinoma

Nagao¹,

Gaffey²,

Serizawa³

et al. 2004

Am J Clin Pathol

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Salivary duct carcinoma (SDC) is an uncommon, high-grade tumor. We present 8 cases of sarcomatoid SDC, which has been defined recently as a rare variant of SDC. The 8 patients (5 men, 3 women) had a mean age of 63.6 years. Histologically, all tumors were characterized by a biphasic neoplasm composed of both SDC and sarcomatoid elements. In 3 cases, sarcomatoid components showed osteosarcomatous heterologous differentiation. A residual pleomorphic adenoma was detected in 5 tumors. The sarcomatoid component showed focal immunoreactivity for cytokeratin in 4 cases and epithelial membrane antigen in all 8 cases. Diffuse p53 immunostaining was detected in 3 cases, and it was coexpressed in both components. Our observations support the histogenetic theory of a common origin of the carcinomatous and sarcomatoid populations. Of the 13 patients, including our 8, reported to have sarcomatoid SDC arising in a major salivary gland and for whom long-term follow-up data were available, 7 have died of disease (mean survival, 15.6 months). These results indicate that sarcomatoid SDC is a highly aggressive tumor, similar to conventional SDC.

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Parotid acinic cell carcinoma with undifferentiated spindle cell transformation

Abstract: This report describes a 59-year-old black man who had an acinic cell carcinoma with associated malignant spindle cell transformation in the parotid gland. To the best of our knowledge, a similar lesion in the salivary gland has not been previously reported.

Cited by 13 publications

References 17 publications

Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

Sarcomatoid salivary duct carcinoma of the oral cavity

Sarcomatoid Variant of Salivary Duct Carcinoma

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