Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

Pelkey, Timothy J.; Mills, Stacey E.

doi:10.1093/ajcp/111.6.785

Cited by 70 publications

(51 citation statements)

References 12 publications

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“…Even though 10-33% of patients develop local recurrences and as many as 9-15% develop nodal metastases [24], PLGA does not metastasize to distant sites or cause patient death. In rare instances, however, PLGA may transform into a highly malignant tumor characterized by high grade morphologic features and more aggressive clinical behavior [29][30][31]. To accommodate this definite albeit rare phenomenon known as high grade transformation [32], the 2017 edition of the Blue Book has abandoned the qualifier "low grade", and now designates these tumours simply as polymorphous adenocarcinomas.…”

Section: Salivary Gland Tumoursmentioning

confidence: 99%

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Westra

Lewis

2017

Head and Neck Pathol

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Section: Salivary Gland Tumoursmentioning

confidence: 99%

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Westra

Lewis

2017

Head and Neck Pathol

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“…The overall survival rate of the patients with conventional PLGA is excellent. However, dedifferentiation of PLGA has been reported and carries a less favorable outcome and a poor prognosis (1,15). Postoperative radiotherapy and/or chemotherapy is generally avoided, except in dedifferentiated PLGA cases due to the risk of aggressive dedifferentiation.…”

Section: Discussionmentioning

confidence: 99%

Polymorphous low-grade adenocarcinoma of the epiglottis: A case report

Larbcharoensub

Sanpaphant

Witoonpanich

et al. 2016

Molecular and Clinical Oncology

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Abstract. Polymorphous low-grade adenocarcinoma is an uncommon malignant tumor derived from the terminal duct cells of the salivary glands. The present study described a rare case of polymorphous low-grade adenocarcinoma, T2N0M0 stage 2, in a 65-year-old man, who presented with a sore throat and painful dysphagia. Computed tomography revealed an infiltrative heterogenous enhancing mass involving the left aryepiglottic fold. He underwent a tumor removal with frozen section for evaluating the surgical margin. Subsequent supraglottic laryngectomy was performed. Polymorphous low-grade adenocarcinoma was diagnosed histologically, characterized by cytologic uniformly, morphologic diversity and an infiltrative growth pattern. Epiglottic cartilaginous invasion by the tumor is demonstrated. Clinical, radiological, endoscopic and pathological features with briefly reviewed relevant literatures are discussed. This is the first reported description in the literature, to the best of our knowledge, of an epiglottic polymorphous low-grade adenocarcinoma receiving successful supraglottic laryngectomy with 7 year disease free survival.

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“…Afin de palier les problèmes fonctionnels en rapport avec la nutrition, la fuite d'air et la phonation, une gouttière avec ou sans obturateur peut être réalisée avec mise en place en attendant la chirurgie réparatrice. La prothèse obturatrice est indiquée dans le cas de grande perte de substances [22,23,24]. Le traitement de la patiente présenté a été similaire à ce que rapporte la littérature.…”

Section: Discussionunclassified

Adénocarcinome polymorphe de bas grade du palais mou : revue et rapport de cas

Naji

Alaoui

Yahya

2016

Med Buccale Chir Buccale

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Résumé -Introduction : L'adénocarcinome polymorphe de bas grade (APBG) est une tumeur maligne rare qui se trouve presque exclusivement située dans les glandes salivaires accessoires. Il survient fréquemment chez les patients entre 30 et 70 ans, avec un ratio femme-homme de 2/1. Il est généralement situé dans le palais dur ou mou. Observation : Il s'agissait d'une patiente de 38 ans, consultant suite à l'apparition d'une tuméfaction bleutée au niveau du palais mou droit, évoluant depuis un an, indolore et recouverte d'une muqueuse d'aspect normal. Le diagnostic évoqué était un adénome pléomorphe mais l'examen histologique après exérèse chirurgicale révélait un APBG. Une reprise des marges d'exérèse était nécessaire associée à une plastie. Discussion : Le diagnostic de l'APBG est basé principalement sur les éléments cliniques et radiologiques. L'anatomopathologie permet la confirmation et la classification de la lésion. Le traitement reste essentiellement chirurgical. Le pronostic est bon malgré un taux de récidive de l'ordre de 17 % à 24 %. Bien que rares, les métastases dans les ganglions lymphatiques régionaux peuvent se produire dans 9 % des cas. Conclusion : L'APBG est une tumeur non agressive dont le pronostic dépend de plusieurs facteurs dont le délai de consultation, d'où l'importance d'un dépistage précoce.Abstract -Polymorphous low-grade adenocarcinoma of the soft palate: review and case report. Introduction: Polymorphous low-grade adenocarcinoma (PLGA) is a rare malignant tumor that is found almost exclusively in the minor salivary glands. It frequently occurs in patients between 30 and 70 years old, with a female to male ratio of 2/1. It is usually located in the hard or soft palate. Observation: A 38-year-old female patient presented with a bluish swelling in the right side of the soft palate which had evolved for a year, which was painless and covered with a mucosa of normal appearance. The first diagnosis suggested was pleomorphic adenoma, but the histologic exam following the surgical biopsy revealed a PLGA. Surgical revision of the safety margins was necessary together with mucosal plasty. Discussion: The diagnosis of PLGA is based mainly on clinical and radiological aspects, but a histologic exam is absolutely necessary to confirm it, and for classification of the lesion. Treatment is mainly surgical. The prognosis is good, although the recurrence rate is 17% to 24%. Although seldom, metastases in regional lymph nodes may occur in 9% of cases. Conclusion: PLGA is a non-aggressive tumor whose prognosis depends on several factors including the consultation period. This highlights the importance of early detection.

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Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

Abstract: Polymorphous low-grade adenocarcinoma of salivary gland origin (PLGA)

Cited by 70 publications

References 12 publications

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx

Polymorphous low-grade adenocarcinoma of the epiglottis: A case report

Adénocarcinome polymorphe de bas grade du palais mou : revue et rapport de cas

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