Sarcomatoid Variant of Salivary Duct Carcinoma

Abstract

Salivary duct carcinoma (SDC) is an uncommon, high-grade tumor. We present 8 cases of sarcomatoid SDC, which has been defined recently as a rare variant of SDC. The 8 patients (5 men, 3 women) had a mean age of 63.6 years. Histologically, all tumors were characterized by a biphasic neoplasm composed of both SDC and sarcomatoid elements. In 3 cases, sarcomatoid components showed osteosarcomatous heterologous differentiation. A residual pleomorphic adenoma was detected in 5 tumors. The sarcomatoid component showed focal immunoreactivity for cytokeratin in 4 cases and epithelial membrane antigen in all 8 cases. Diffuse p53 immunostaining was detected in 3 cases, and it was coexpressed in both components. Our observations support the histogenetic theory of a common origin of the carcinomatous and sarcomatoid populations. Of the 13 patients, including our 8, reported to have sarcomatoid SDC arising in a major salivary gland and for whom long-term follow-up data were available, 7 have died of disease (mean survival, 15.6 months). These results indicate that sarcomatoid SDC is a highly aggressive tumor, similar to conventional SDC.

Hybrid Carcinoma of the Parotid Gland: An Extremely Rare Three Cases with an Immunohistochemical Analysis and a Review of the Literature

“…These entities include collision tumors, synchronous tumors, multiple tumors, 29 carcinoma with metaplastic changes, carcinoma with high-grade transformation (HGT) (dedifferentiated carcinoma), 30 and the sarcomatoid variant of SDC. 31 As all of our cases involved two distinct carcinomas in the same topological area, which had combined to produce a single tumor mass, they were defined as HC. On the other hand, collision tumor is defined as subsequently contact lesions, which consist of two or more tumor components arising near location but in different areas.…”

Bone marrow metastases in salivary duct carcinoma of the parotid gland

“…The most distinguishing feature is the presence of an intraductal component which is relatively specific of the diagnosis. Variants include sarcomatoid, mucin rich, low-grade SDC and micropapillary SDC 16–18. The presence of flat sheets of irregular tumour cells, with invasive features and with intraductal components are characteristic features of SDC 19.…”

Oncocytic Lesions of Salivary Glands: Morphological, Immunohistochemical, and Molecular Findings

“…SDC typically has more cellular atypia and mitoses compared to breast carcinoma [31]. There are different variants of SDC, but they usually appear in combination with the typical features of SDC [32][33][34]. An oncocytic variant of SDC having >50% components shows oncocytic changes characterized by enlarged cells with abundant eosinophilic granular cytoplasm and a centrally placed nucleus (Figure 6B).…”

“…An oncocytic variant of SDC having >50% components shows oncocytic changes characterized by enlarged cells with abundant eosinophilic granular cytoplasm and a centrally placed nucleus (Figure 6B). Sarcomatoid, invasive micropapillary, and rhabdoid SDC have a poorer prognosis than conventional SDC [33][34][35]. IHC shows a strong and diffuse expression of the androgen receptor (AR) is a characteristic feature of SDC (Figure 6C).…”