Sarcomatoid salivary duct carcinoma of the oral cavity

Abstract

This report recounts a new case of sarcomatoid variant of salivary duct carcinoma in a 45-year-old woman. The 1.5-cm polypoid mass protruded from the retromolar area and focally extended into the pharyngeal wall. The patient was free of disease for 11 years. The tumor showed a biphasic malignancy; nondescript sarcomatous proliferation predominated over ductal carcinoma population, with perceptible blending of the two components. The sarcomatoid areas had no heterologous properties. Discohesive pleomorphic cells were immunopositive for vimentin, epithelial membrane antigen and AE1/AE3 at a significant rate. A dual expression of AE1/AE3 and vimentin was also evident in enmeshed foci of conventional cribriform adenocarcinoma. Thus, the sarcomatoid histology represents a dedifferentiated phenotype of salivary duct carcinoma.

Mucoepidermoid Carcinoma with Spindle Cell Change: A Low-grade Lesion Potentially Mistaken for Sarcomatoid Dedifferentiation

“…Dedifferentiation in the form of high-grade sarcomatoid tumor has been documented in nearly every type of salivary gland carcinomas [3,8,[10][11][12][13]. Our case must be distinguished cautiously from dedifferentiated MEC [7,14].…”

Sarcomatoid Salivary Duct Carcinoma of the Submandibular Gland

“…A carcinomatous component shows the cytomorphologic aspect of conventional SDC with cribriform or solid cell nests, ductal carcinoma in situ,and comedonecrosis, whereas a sarcomatoid component is composed of mitotically active, pleomorphic spindle cells and anaplastic tumor giant cells. [1][2][3][4][5] In the present case, the histologic findings of sarcomatoid SDC described above were detected. Furthermore, in the present case, a squamous cell carcinoma component was also found.…”

“…There have been dozens of reports of histologic findings of sarcomatoid SDC. [1][2][3][4][5] Histologically, sarcomatoid SDC is characterized by the presence of both a carcinomatous and a sarcomatoid component. A carcinomatous component shows the cytomorphologic aspect of conventional SDC with cribriform or solid cell nests, ductal carcinoma in situ,and comedonecrosis, whereas a sarcomatoid component is composed of mitotically active, pleomorphic spindle cells and anaplastic tumor giant cells.…”

“…There have since been dozens of reports, [1][2][3][4][5] but only 1 case report has described the cytologic findings. 4 We encountered sarcomatoid SDC with a squamous cell carcinoma component that developed from a submandibular gland pleomorphic adenoma, and we present details of the cytologic and histopathologic findings of this case.…”

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

“…Dedifferentiation in salivary gland carcinomas other than ADCC is a rare but well recognized phenomenon and has been documented in epithelial-myoepithelial carcinoma (EMECa) [34][35][36][37][38], acinic cell carcinoma [39][40][41][42][43][44], mucoepidermoid carcinoma [45,46], polymorphous low-grade adenocarcinoma [47,48], hyalinizing clear cell carcinoma [49] and salivary duct carcinoma [50][51][52][53]. In the dedifferentiated (recurrent) acinic cell carcinoma presented by Piana et al [42], there was evidence of myoepithelial differentiation (clear cell morphology, widespread positivity for S100 protein and focal immunoreactivity for SMA).…”