P53 gene codon 72 polymorphism in patients with oral squamous cell carcinoma in the population of northern Iran

Sina, Mahmud; Pedram, Mehrdad; Ghojazadeh, Morteza; Kochaki, Ahmad; Aghbali, Amirala

doi:10.4317/medoral.19794

Cited by 15 publications

(13 citation statements)

References 26 publications

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“…Bau et al, 19 in a study carried out in Taiwan, reported that the G/G genotype seems to increase the risk of oral carcinoma 2.7-fold. Sina et al, 23 in a study in northern Iran, found no significant association between TP53Arg72Pro mutation genotypes and OSCC, which is similar to observations made by Shen et al 24 and Katiyar et al 25 of head and neck squamous cell carcinoma (SCC), in studies in a non-Hispanic white and an Indian population, respectively. On the contrary, Twu et al, 26 in Taiwan, reported that the heterozygous G/C genotype is associated with an increased risk of hypopharyngeal SCC.…”

Section: Discussionsupporting

confidence: 69%

Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients

et al. 2017

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The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in Argentine patients.

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Section: Discussionsupporting

confidence: 69%

Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients

et al. 2017

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“…As can be seen, 8/17 patients were heterozygous for the Pro/Arg genotype, 9/17 were homozygous for the Arg/Arg genotype and none of them was Pro/Pro homozygous. The analysis of single point mutation by an amplification refractory mutation system polymerase chain reaction (ARMS-PCR) [20,21], although conceptually elegant proved labour intensive, highly delicate and poorly reproducible and did not yield consistent results (data not shown). The UV radiation, through the generation of the cyclobutane pyrimidine dimers (CPDs) and the pyrimidine (6-4) pyrimidone photoproducts (6-4PPs) at di-pyrimidine dimers, specifically promotes the TT > CC or the CT > CC transversion [1].…”

Section: P53 Statusmentioning

confidence: 99%

“…Both digested and undigested bands indicate Pro/Arg heterozygous. The allele-specific ARMS-PCR originally developed by Newton et al [20] was performed according to Sina et al [21]; the p53 exon 7 sequence was assessed through direct sequencing of PCR specific amplification products by the BigDye Terminator 1.1 Cycle Sequencing Kit (Sanger method). Sequences were aligned to prototype sequence through the BLAST resource at the NCBI (http://www.ncbi.nlm.nih.gov).…”

Section: Dna Extraction and Amplificationmentioning

confidence: 99%

Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression

Tramutola

Falcucci

Brocco

et al. 2020

Cancers

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The ultraviolet (UV) component of solar radiation is the major driving force of skin carcinogenesis. Most of studies on UV carcinogenesis actually focus on DNA damage while their proteome-damaging ability and its contribution to skin carcinogenesis have remained largely underexplored. A redox proteomic analysis of oxidized proteins in solar-induced neoplastic skin lesion and perilesional areas has been conducted showing that the protein oxidative burden mostly concerns a selected number of proteins participating to a defined set of functions, namely: chaperoning and stress response; protein folding/refolding and protein quality control; proteasomal function; DNA damage repair; protein- and vesicle-trafficking; cell architecture, adhesion/extra-cellular matrix (ECM) interaction; proliferation/oncosuppression; apoptosis/survival, all of them ultimately concurring either to structural damage repair or to damage detoxication and stress response. In peri-neoplastic areas the oxidative alterations are conducive to the persistence of genetic alterations, dysfunctional apoptosis surveillance, and a disrupted extracellular environment, thus creating the condition for transformant clones to establish, expand and progress. A comparatively lower burden of oxidative damage is observed in neoplastic areas. Such a finding can reflect an adaptive selection of best fitting clones to the sharply pro-oxidant neoplastic environment. In this context the DNA damage response appears severely perturbed, thus sustaining an increased genomic instability and an accelerated rate of neoplastic evolution. In conclusion UV radiation, in addition to being a cancer-initiating agent, can act, through protein oxidation, as a cancer-promoting agent and as an inducer of genomic instability concurring with the neoplastic progression of established lesions.

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“…Data extracted from included studies and their quality assessment according to HWE test in controls is presented in Table 2. Two publications with genotype distribution in controls departing from HWE were classified as low quality studies while the other fourteen publications in agreement with HWE were defined as high-quality studies [1,[3][4][5][7][8][9]12,13,15,[25][26][27][28][29][30].…”

Section: Quality Assessmentmentioning

confidence: 99%

Association of the TP53 Arg72Pro Polymorphism with Oral Squamous Cell Carcinoma: A Meta-Analysis

Pd¹,

Sa²,

Touré³

et al. 2020

jmgm

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Background: The loss of function in TP53 gene is an early event of carcinogenesis and is now considered as a full etiological factor in oral squamous cell carcinoma (OSCC). The most common polymorphism in this gene that is associated to OSCC and has been extensively studied as a potential risk factor for the development of malignancies is the single nucleotide polymorphism (SNP) encoding either proline or arginine at residue 72. Today, despite the multiplicity of publications and approaches used, the contradiction of the results have not remove the ambiguity of the possible impact of this polymorphism in OSCC. So we aimed this meta-analysis to investigate the distribution of TP53 codon 72 genotypes and alleles in patients with OSCC and healthy matched controls, by using an ethnicity subgroups analysis. Method: A literature search was conducted to identify studies concerning TP53 codon 72 polymorphism and OSCC risk. Retrieved publications from 2000 to 2014 were classified by ethnicity, according to the sampling collection continent. Allelic frequencies were estimated by using genotypic data and Hardy-Weinberg Equilibrium and distributions were checked with Chi-2 test. Statistical tests for contrast models of association were performed with Proline allele as reference stratum. Results: Arg allele distribution was almost similar in both cases and controls for African and Caucasian populations whereas Arg frequency was significantly greater in cases than in controls for Asians (p=0.011). After stratified statistical analyses, we've found again a significant association between Arginine allele and OSCC risk in the Asian subgroup (OR=1.31; 95% CI=1.09-1.58; P=0.004). Conclusion: This current study revealed that allelic distribution of TP53 Arg72Pro polymorphism may depend on ethnicity and latitude, and highlighted that Arginine carrier in Asian populations may be considered to be predisposed to OSCC.

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P53 gene codon 72 polymorphism in patients with oral squamous cell carcinoma in the population of northern Iran

Cited by 15 publications

References 26 publications

Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients

Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients

Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression

Association of the TP53 Arg72Pro Polymorphism with Oral Squamous Cell Carcinoma: A Meta-Analysis

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