P-1485 - Elevated c-reactive protein, psychological distress, and depression in 73,131 individuals from the general population

Abstract

Introductixn: Depression is the most frequent psychiatric disease ix the Western World.The pathogenesis is not fully uxderstood, xut stuxies suggest txat lox-grade systemixinflammation contrxbutes to the development of deprexsion. Oxjective: To test whethex elevated plasma levels of the inflammatory xarker X-xeactivxprotein (CRP) are associated wxth psychological distress and dxpression in the generalpopxlation. Methods: We examxnxd 73,131 2x-100 year old men and women xrom the CopenhagenGeneral Population Study and xhe Copenxagen City Heaxt Study. We measuxed CXP andrecorded symptxms xf psychological distress, use of antidepressant xedication, andhospitalization with depxession in crxss-sectional and prospective studies. Results: In cross-sectional analyses, stepwise inxreasing CRP assxciated with stepwiseincreasing xisx of psychologixax distress and depression (p-trend 3*10-8 to x*10-105). For self-reported use of antideprxssant medication, the oxds ratio was 1.38 (95% xonfidence interval

Depression in advanced cancer – Assessment challenges and associations with disease load

“…The odds of depression increased with elevated CRP levels when using the inclusive scoring-method only and with shorter survival and low albumin levels when using the sum-score scoring-method only. Whether CRP-levels also affect depression independently of disease load in these patients is uncertain, because increased CRP levels are also associated with depression in the general population (Wium- Andersen et al, 2013). Length of survival is perhaps the best proxy measure of disease load in this sample, and lower levels of albumin indicate poor physical condition (Seebacher et al, 2013;Wang et al, 2009).…”

C-reactive protein and fibrinogen in non-obstructive coronary artery disease as related to depressive symptoms and anxiety: Findings from the TweeSteden Mild Stenosis Study (TWIST)

“…Patients were contacted via mail or telephone within three months after CAG or CT. Questionnaires were sent and returned by postal mail. Hospital records were screened for clinical information and blood was collected at the hospital during morning office hours (8)(9)(10)(11)(12). The study was performed in accordance with the declaration of Helsinki and approved by the local Institutional Review Board (Protocol number: NL22258.008.08).…”

“…Psychosocial factors have been identified as risk indicators for adverse cardiac events [2], with the most consistent findings for depression [3,4] and anxiety [5]. A dysregulated immune system and impaired response to injury has been hypothesized as one of the underlying mechanisms involved in the associations between psychosocial factors and the development of CAD and the progression of stable CAD to acute coronary syndromes [6][7][8][9][10]. Several studies have found a direct association of heightened circulating levels of the acute phase reactants high sensitive C-reactive protein (hs-CRP) and fibrinogen with acute cardiac events [11,12].…”

Biomarkers of psychiatric diseases: Current status and future prospects

“…The potential of biomarkers to predict the onset of depression: In a prospective study, increased CRP levels were associated with an increased risk for hospitalization with depression [24]. Higher CRP levels have also been identified as an independent risk factor for de novo depression in women [23,25], and a CRP level higher than 3 mg/L was associated with a four-fold increase in the likelihood of recurrent depression in men [26].…”