Biomarkers of psychiatric diseases: Current status and future prospects

Kalia, Madhu; Silva, Jorge Costa e

doi:10.1016/j.metabol.2014.10.026

Cited by 82 publications

(65 citation statements)

References 57 publications

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“…Alterations of peripheral biomarkers of brain structure and function might shed light on the pathological changes in central mechanisms. Brain derived neurotrophic factor (BDNF), S100B and neuron specific enolase (NSE) are among the most studied biomarkers in affective disorders, in particular major depressive disorder (Schroeter et al, 2002;Hetzel et al, 2005;Andreazza et al, 2007;Schroeter and Steiner, 2009;Kalia and Silva, 2015).…”

Section: Introductionmentioning

confidence: 99%

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

et al. 2016

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Minor depression is diagnosed when a patient suffers from 2 to 4 depressive symptoms for at least 2 weeks. Though minor depression is a widespread phenomenon, its pathophysiology has hardly been studied. To get a first insight into the pathophysiological mechanisms underlying this disorder we assessed serum levels of biomarkers for plasticity, glial and neuronal function: brain-derived neurotrophic factor (BDNF), S100B and neuron specific enolase (NSE). 27 subjects with minor depressive episode and 82 healthy subjects over 60 years of age were selected from the database of the Leipzig population-based study of civilization diseases (LIFE). Serum levels of BDNF, S100B and NSE were compared between groups, and correlated with age, body-mass index (BMI), and degree of white matter hyperintensities (score on Fazekas scale). S100B was significantly increased in males with minor depression in comparison to healthy males, whereas other biomarkers did not differ between groups (p = 0.10-0.66). NSE correlated with Fazekas score in patients with minor depression (r s = 0.436, p = 0.048) and in the whole sample (r s = 0.252, p = 0.019). S100B correlated with BMI (r s = 0.246, p = 0.031) and with age in healthy subjects (r s = 0.345, p = 0.002). Increased S100B in males with minor depression, without alterations in BDNF and NSE, supports the glial hypothesis of depression. Correlation between white matter hyperintensities and NSE underscores the vascular hypothesis of late life depression.

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Section: Introductionmentioning

confidence: 99%

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

et al. 2016

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“…Clinical psychiatry involves continuous attempts to identify relevant biomarkers for mental states, disease progression and prognosis [1]. Inflammation has gained much interest as data accumulates to point its association with psychopathological symptoms [2-7].…”

Section: Introductionmentioning

confidence: 99%

Association between Elevated C-Reactive Protein and Manic Polarity in Acute Psychiatric Inpatients with Affective Symptomatology

et al. 2017

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The interplay between the immune system and behaviour is of increasing interest in psychiatry research. Specifically, accumulating data points to a link between inflammation and psychopathology, including affective symptomatology. We investigated the association between inflammation and affective polarity in psychiatric inpatients who were hospitalized due to an affective exacerbation. Data was collected retrospectively and comparisons were made between manic and depressed patients. C-reactive protein (CRP), a general laboratory marker of immune activation and inflammation, was used as a non-specific inflammatory biomarker. Age, smoking and body mass index were considered covariates. Manic polarity (n = 89) was associated with statistically significant elevated CRP levels compared to depressed polarity (n = 44, 56%; p = 0.036), after controlling for covariates. No differences were observed in CRP levels across Diagnostic and Statistical Manual of Mental Disorders-IV Edition-Text Revised psychiatric diagnoses. These findings suggest a transdiagnostic association between inflammation and manic polarity in affective inpatients.

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“…Interest in understanding molecular pathways and potential biomarkers for neuropsychiatric disorders has led to advances in neuroscience and genetic research (Kalia & Costa, 2015). The AUD cohorts have been studied using advanced techniques including MALDI Imaging (Yalcin & de la Monte, 2015) and RNA Sequencing (Farris, Arasappan, Hunicke-Smith, Harris, & Mayfield, 2015).…”

Section: Introductionmentioning

confidence: 99%

The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research

Sutherland

Sheedy

Stevens

et al. 2016

Alcohol

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The New South Wales Brain Tissue Resource Centre (NSWBTRC) at the University of Sydney (Australia) is an established human brain bank providing tissue to the neuroscience research community for investigations on alcohol-related brain damage and major psychiatric illnesses such as schizophrenia. The NSWBTRC relies on wide community engagement to encourage those with and without neuropsychiatric illness to consent to donation through its allied research programs. The subsequent provision of high-quality samples relies on standardized operational protocols, associated clinical data, quality control measures, integrated information systems, robust infrastructure, and governance. These processes are continually augmented to complement the changes in internal and external governance as well as the complexity and diversity of advanced investigation techniques. This report provides an overview of the dynamic process of brain banking and discusses the challenges of meeting the future needs of researchers, including synchronicity with other disease-focus collections.

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Biomarkers of psychiatric diseases: Current status and future prospects

Cited by 82 publications

References 57 publications

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

Association between Elevated C-Reactive Protein and Manic Polarity in Acute Psychiatric Inpatients with Affective Symptomatology

The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research

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