Oxidative stress in macrophages from spleen of Nile tilapia (Oreochromis niloticus) exposed to sublethal concentration of endosulfan

Téllez‐Bañuelos, Martha Cecilia; Santerre, Anne; Casas‐Solís, Josefina; Bravo-Cuéllar, Alejandro; Zaitseva, Galina

doi:10.1016/j.fsi.2008.11.002

Cited by 83 publications

(41 citation statements)

References 37 publications

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“…The immune organs are also putative targets for EDCs as evidenced by the anatomical and morphological changes that are observed in lymphoid tissues following toxicant exposure to xenoestrogens and xenoandrogens. Spleno-somatic and hepato-somatic indices and thymus volume are affected by the exposure to sex-steroids (androgens and estrogens) or to their related endocrine disruptors (Christiansen et al 1998;Thorpe et al 2000;Vainikka et al 2005;Kurtz et al 2007;Grinwis et al 2009;Tellez-Bañuelos et al 2009;Van Ginneken et al 2009). In addition to these effects, EDCs are associated with histological disruption in contaminated fish.…”

Section: Interactions Between the Reproductive And Immune Systems In mentioning

confidence: 99%

The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review

2011

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During the last decade, a number of studies have shown that, in addition to their classically described reproductive function, estrogens and androgens also regulate the immune system in teleosts. Today, several molecules are known to interfere with the sex-steroid signaling. These chemicals are often referred to as endocrine disrupting contaminants (EDCs). We review the growing evidence that these compounds interfere with the fish immune system. These studies encompass a broad range of approaches from field studies to those at the molecular level. This integrative overview improves our understanding of the various endocrine-disrupting processes triggered by these chemicals. Furthermore, the research also explains why fish that have been exposed to EDCs are more sensitive to pathogens during gametogenesis. In this review, we first discuss the primary actions of sex-steroid-like endocrine disruptors in fish and the specificity of the fish immune system in comparison to mammals. Then, we review the known interactions between the immune system and EDCs and interpret the primary effects of sex steroids (estrogens and androgens) and their related endocrine disruptors on immune modulation. The recent literature suggests that immune parameters may be used as biomarkers of contamination by EDCs. However, caution should be used in the assessment of such immunotoxicity. In particular, more attention should be paid to the specificity of these biomarkers, the external/internal factors influencing the response, and the transduction pathways induced by these molecules in fish. The use of the well-known mammalian models provides a useful guide for future research in fish.

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Section: Interactions Between the Reproductive And Immune Systems In mentioning

confidence: 99%

The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review

2011

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“…According Milatovic et al (2005), Ren et al (2008) and Tellez-Bañuelos et al (2009) pesticides as carbofuran and endosulfan, respectively, produce oxidative stress, as measured by increased generation of reactive oxygen and nitrogen species what can leads to alterations in the membrane structure and functions. Mecocci et al (1997) suggest that these degenerative changes can affect dynamic properties of the membranes such as fluidity and permeability, and consequently the activity of various membraneassociated enzymes.…”

Section: Discussionmentioning

confidence: 99%

Effect of roundup® (glyphosate formulation) in the energy metabolism and reproductive traits of Hyalella castroi (Crustacea, Amphipoda, Dogielinotidae)

et al. 2010

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Roundup(®) (glyphosate formulation) is a nonselective and posts emergent herbicide used for controlling aquatic weeds and different concentrations are used in cultures around the world. The objective of this investigation was to examine the effects of Roundup(®) (glyphosate formulation) on the biochemical composition, levels of lipoperoxidation, Na(+)/K(+)ATPase activity and reproductive traits in the Hyalella castroi. Amphipods were collected in summer 2009, in the southern Brazilian highlands. In the laboratory, the animals were kept in aquariums under controlled conditions for 7 days, and after this period they were exposed to 0.36, 0.52, 1.08 and 2.16 mg/l of glyphosate for 7 days. After the period of exposure, the animals were immediately frozen for determination of glycogen, proteins, lipids, triglycerides, cholesterol, levels of lipoperoxidation, and Na(+)/K(+)ATPase activity. During each day of the cultivation reproductive traits (number of reproductive pairs, ovigerous females and eggs in the marsupium) were observed. All concentrations of Roundup(®) induced significant decreases in all biochemical parameters and Na(+)/K(+)ATPase activity, and significant increase in lipoperoxidation levels. Showing this form a potentially toxic effect at very low concentrations, this pattern of results can lead to significant changes in trophic structure of limnic environments because these amphipods are important links in food chain in these habitats.

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“…In another study, crimson-spotted rainbowfish (Melanotaenia fluviatilis), golden perch (Macquaria ambigua) and Murray cod (Maccullochella peelii), but not silver perch (Bidyanus bidyanus), leucocytes showed decreased phagocytosis after endosulfan treatment (10 mg/L) (Harford et al, 2005). In vivo treatment of Nile tilapia for 96 h at 7 ppb produced an increased phagocytosis and ROS production by spleen leucocytes, IgM levels and production of IL-2-like, but at the same time reduced the spleen viability and relative weight (Tellez-Bañuelos et al, 2009.…”

Section: Organochlorinated (Ocs) Contaminantsmentioning

confidence: 98%

Immunotoxicological Effects of Environmental Contaminants in Teleost Fish Reared for Aquaculture

Cuesta¹,

Meseguer²,

Esteban³

2011

Pesticides in the Modern World - Risks and Benefits

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Oxidative stress in macrophages from spleen of Nile tilapia (Oreochromis niloticus) exposed to sublethal concentration of endosulfan

Cited by 83 publications

References 37 publications

The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review

The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review

Effect of roundup® (glyphosate formulation) in the energy metabolism and reproductive traits of Hyalella castroi (Crustacea, Amphipoda, Dogielinotidae)

Immunotoxicological Effects of Environmental Contaminants in Teleost Fish Reared for Aquaculture

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