Immunotoxicological Effects of Environmental Contaminants in Teleost Fish Reared for Aquaculture

Cuesta, Alberto; Meseguer, José; Esteban, María Ángeles

doi:10.5772/17430

Cited by 13 publications

(10 citation statements)

References 155 publications

(108 reference statements)

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“…Thus, in vivo studies have usually confirmed that heavy metals decrease the humoral (antibody levels, lysozyme or complement activity, C-reactive protein, etc.) and cellular (leucocyte count, cellmediated cytotoxic activity, phagocytosis or respiratory burst) immunity of fish, though some other studies have also documented no effect or even increments (Bols et al, 2001;Cuesta et al, 2011). Interestingly, some studies have documented histological alterations of immune tissues connecting with the effects in the leucocyte viability, functions and finally disease resistance (De Oliveira-Ribeiro et al, 2002;Guardiola et al, 2013a,b;Mela et al, 2014).…”

Section: Introductionmentioning

confidence: 90%

Toxicological in vitro effects of heavy metals on gilthead seabream (Sparus aurata L.) head–kidney leucocytes

Morcillo

Cordero

Meseguer

et al. 2015

Toxicology in Vitro

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Section: Introductionmentioning

confidence: 90%

Toxicological in vitro effects of heavy metals on gilthead seabream (Sparus aurata L.) head–kidney leucocytes

Morcillo

Cordero

Meseguer

et al. 2015

Toxicology in Vitro

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“…With increasing anthropogenic and industrial activities, heavy metals can become soluble and accumulate to toxic levels, and potentially affect the thyroid axis (388). Cadmium decreases TH levels in rainbow trout (389), while chromium exposure reduces TH levels in European eel (390), and induces thyroid follicle hypertrophy and increases in serum TH levels in spotted snakehead (Channa punctatus) (391).…”

Section: Pollutantsmentioning

confidence: 99%

The Role of the Thyroid Axis in Fish

2020

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In all vertebrates, the thyroid axis is an endocrine feedback system that affects growth, differentiation, and reproduction, by sensing and translating central and peripheral signals to maintain homeostasis and a proper thyroidal set-point. Fish, the most diverse group of vertebrates, rely on this system for somatic growth, metamorphosis, reproductive events, and the ability to tolerate changing environments. The vast majority of the research on the thyroid axis pertains to mammals, in particular rodents, and although some progress has been made to understand the role of this endocrine axis in non-mammalian vertebrates, including amphibians and teleost fish, major gaps in our knowledge remain regarding other groups, such as elasmobranchs and cyclostomes. In this review, we discuss the roles of the thyroid axis in fish and its contributions to growth and development, metamorphosis, reproduction, osmoregulation, as well as feeding and nutrient metabolism. We also discuss how thyroid hormones have been/can be used in aquaculture, and potential threats to the thyroid system in this regard.

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“…Fish immune system organization presents specific characteristics because fish lack bone marrow and lymphatic nodules (see [49,50]). Thus, pronephros (anterior/head kidney) is the main lympho-haematopoietic tissue in fish and is the primary site for the development and production of B cells.…”

Section: A Brief Summary Of Fish Immunitymentioning

confidence: 99%

Influence of Melatonin on the Immune System of Fish: A Review

Esteban

Chaves-Pozo

Meseguer

2013

IJMS

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Endocrine-immune system interactions have been widely demonstrated in mammals, whereas in fish, these relationships remain unclear. Of the organs that constitute the endocrine system, the pineal gland and its secretory product melatonin act in the synchronization of daily and seasonal rhythms in most vertebrates, including fish. Seasonal differences in immunocompetence and disease prevalence have been well documented in humans. Seasonality also strongly influences the life history of fish by controlling the timing of physiological events, such as reproduction, food intake, locomotor activity, and growth performance. Apart from its synchronizing capabilities, the role of melatonin in physiological processes in fish is not thoroughly understood. The purpose of this review is to summarize current studies on the effects of melatonin on the fish immune system. These studies suggest that melatonin represents an important component of fish endocrine-immune system interactions. The elucidation of the defense mechanisms of fish will facilitate the development of health management tools to support the growing finfish aquaculture industry as well as address questions concerning the origins and evolution of the immune system in vertebrates.

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Immunotoxicological Effects of Environmental Contaminants in Teleost Fish Reared for Aquaculture

Cited by 13 publications

References 155 publications

Toxicological in vitro effects of heavy metals on gilthead seabream (Sparus aurata L.) head–kidney leucocytes

Toxicological in vitro effects of heavy metals on gilthead seabream (Sparus aurata L.) head–kidney leucocytes

The Role of the Thyroid Axis in Fish

Influence of Melatonin on the Immune System of Fish: A Review

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