Oxidative stress and the etiology of male infertility

Aitken, R. John

doi:10.1007/s10815-016-0791-4

Cited by 41 publications

(37 citation statements)

References 15 publications

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“…The most frequent and typical causes for male infertility are represented by varicocele, cryptorchidism, infections, obstructive lesions, trauma, and cancer [ 1 ]; noteworthily, the exact etiology of male factor infertility still remains undiagnosed in about 30% to 50% of patients, who therefore are classified as idiopathic cases [ 4 ]. There is increasing evidence that oxidative stress (OS) represents a condition having a key role in the etiology of male infertility and thus it has been studied extensively [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Respiratory Mitochondrial Efficiency and DNA Oxidation in Human Sperm after In Vitro Myo-Inositol Treatment

Governini

Ponchia

Artini

et al. 2020

JCM

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Semen samples are known to contain abnormal amounts of reactive oxygen species (ROS) and oxygen free radicals; therefore, the identification of antioxidant molecules able to counteract the oxidative damage caused by ROS is foresight. Indeed, improving semen quality in terms of motility and reduction in DNA damage, can significantly improve the fertilization potential of sperm in vitro. To this regard, myo-inositol, based on its antioxidant properties, has been reported to be effective in improving sperm quality and motility in oligoasthenozoospermic patients undergoing assisted reproduction techniques when used as a dietary supplementation. Moreover, in vitro treatment demonstrated a direct relationship between myo-inositol, mitochondrial membrane potential and sperm motility. This experimental study aimed to evaluate the effects of myo-inositol (Andrositol-lab) in vitro treatment on sperm motility, capacitation, mitochondrial oxidative phosphorylation and DNA damage. Our results demonstrate that myo-inositol induces a significant increase in sperm motility and in oxygen consumption, the main index of oxidative phosphorylation efficiency and ATP production, both in basal and in in vitro capacitated samples. Moreover, we provide evidence for a significant protective role of myo-inositol against oxidative damage to DNA, thus supporting the in vitro use of myo-inositol in assisted reproductive techniques. Even if further studies are needed to clarify the mechanisms underlying the antioxidant properties of myo-inositol, the present findings significantly extend our knowledge on human male fertility and pave the way to the definition of evidence-based guidelines, aiming to improve the in vitro procedure currently used in ART laboratory for sperm selection.

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Section: Introductionmentioning

confidence: 99%

Respiratory Mitochondrial Efficiency and DNA Oxidation in Human Sperm after In Vitro Myo-Inositol Treatment

Governini

Ponchia

Artini

et al. 2020

JCM

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“…It is consensus to admit multifactorial cause for low seminal quality, highlighting oxidative stress, hypercytokinemia and uremia which are responsible for sperm dysfunction. 18,19 This would cause profound and direct changes in the physiology of the hematotesticular barrier modifying the local paracrine/autocrine systems and other mechanisms which are responsible for maintaining the immune privileged condition of the testes. 19,20 This study has two limitations: the lack of measurement of total seminal antioxidant capacity and a small sample size.…”

Section: Discussionmentioning

confidence: 99%

Semen Quality and Ferritin and Transferrin Seminal Levels

2018

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Background: We proposed to investigate the possible relationship between seminal quality and ferritin and transferrin seminal levels in chronic hemodialysis (CH) patients. Materials and methods: This is a cross-sectional study in a group of 60 men (case) undergoing CH for more than 6 months, and a group of 30 healthy men (control), aged 18-60 years, without clinical or laboratory signs of infection/inflammation and eugonadic. A spermogram was performed by manual method and measured the ferritn and transferrin seminal levels. Results: The case and control groups were age-matched (49.47±5.56 versus 47.90±6.22, p = 0.229). Comparison between case and control group, the exception of seminal ferritin levels that were similar (p = 0.136), were significantly lower in the case group (p<0.001) for all constituents of the seminal parameter and seminal transferrin levels. Seminal ferritin does not appear to be associated with seminal parameters and seminal transferrin (p>0.05); but there was an association between seminal transferrin and seminal parameters (p<0.001). Conclusions: Our results suggest that seminal quality is related to seminal transferrin level and not with seminal ferritin level being useful in the initial evaluation of chronic hemodialysis patients with clinical suspicion of sub / infertility.

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“…After the contribution of uremic factor in the lowering of seminal quality in patients with renal failure was recognized (16,20), the contribution of the oxidative/inflammatory factors was emphasized (21,22). Patients undergoing hemodialysis can be characterized by increased levels of oxidative stress and inflammation (23).…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation and Seminal Parameters in Chronic Hemodialysis Patients

2018

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Objectives: We proposed to investigate the possible effect and association of systemic inflammation (SI) and seminal parameter indicators in chronic hemodialysis patients. Methods: This was a case-control study. All the participants were subjected to a spermiogram with calculation of fertility index (FI), serum C-reactive protein (CRP) level, seminal transferrin (ST) level, as well as evaluation of the hormonal profile (HP). The sample consisting of 60 men (cases) undergoing hemodialysis for more than 6 months was subdivided into 3 groups: group 1 (n = 30, with inflammation, CRP > 5 mg/L), group 2 (n = 30, without inflammation, CRP ≤ 5 mg/L), and group 3 (n = 30, healthy men, CRP ≤ 1). Results:Age was similar in the 3 groups (P = 0.43). FI, testosterone total (TT) and ST levels were significantly lower in the case groups than in the control group (P < 0.001). Follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) levels were significantly higher in the case groups than in the control group (P < 0.001). Between the subgroups of cases (groups 1 and 2), the inflammatory factor alone does not seem to interfere with the FI, HP, and ST level (P > 0.05). However, it significantly interfered with the FI, HP, and ST level when compared between the case groups and the control group (P < 0.001). No correlation was observed between SI and analyzed parameters (P > 0.05). Conclusions:The results suggest that the SI alone has no effect and is not associated with the FI or ST level in a patient undergoing chronic hemodialysis.

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Oxidative stress and the etiology of male infertility

Cited by 41 publications

References 15 publications

Respiratory Mitochondrial Efficiency and DNA Oxidation in Human Sperm after In Vitro Myo-Inositol Treatment

Respiratory Mitochondrial Efficiency and DNA Oxidation in Human Sperm after In Vitro Myo-Inositol Treatment

Semen Quality and Ferritin and Transferrin Seminal Levels

Systemic Inflammation and Seminal Parameters in Chronic Hemodialysis Patients

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