Systemic Inflammation and Seminal Parameters in Chronic Hemodialysis Patients

Abstract

Objectives: We proposed to investigate the possible effect and association of systemic inflammation (SI) and seminal parameter indicators in chronic hemodialysis patients. Methods: This was a case-control study. All the participants were subjected to a spermiogram with calculation of fertility index (FI), serum C-reactive protein (CRP) level, seminal transferrin (ST) level, as well as evaluation of the hormonal profile (HP). The sample consisting of 60 men (cases) undergoing hemodialysis for more than 6 months was subdivided into 3 groups: group 1 (n = 30, with inflammation, CRP > 5 mg/L), group 2 (n = 30, without inflammation, CRP ≤ 5 mg/L), and group 3 (n = 30, healthy men, CRP ≤ 1). Results:Age was similar in the 3 groups (P = 0.43). FI, testosterone total (TT) and ST levels were significantly lower in the case groups than in the control group (P < 0.001). Follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) levels were significantly higher in the case groups than in the control group (P < 0.001). Between the subgroups of cases (groups 1 and 2), the inflammatory factor alone does not seem to interfere with the FI, HP, and ST level (P > 0.05). However, it significantly interfered with the FI, HP, and ST level when compared between the case groups and the control group (P < 0.001). No correlation was observed between SI and analyzed parameters (P > 0.05). Conclusions:The results suggest that the SI alone has no effect and is not associated with the FI or ST level in a patient undergoing chronic hemodialysis.

Testicular sperm retrieval in hemodialysis patients with anejaculation

“…Although the exact mechanism by which HD impair spermatogenesis is unknown, HD patients compared with healthy control have markedly higher serum FSH levels because of the severe impairment of spermatogenesis 5 . Moreover, HD patients without ejaculation disorder tended to have higher serum FSH levels and poorer semen parameter than healthy controls 6 …”