Oxidative stress and heart rate variability in patients with vertigo

Abstract

Aims: Peripheral vertigo has been reported to result from oxidative stress or autonomic nervous dysfunction. Recently, heart rate variability has been used to evaluate autonomic nervous activity. Parasympathetic nervous dysfunction is associated with peripheral vertigo; however, the relationships between vertigo, oxidative stress, and autonomic nervous activity have not been investigated. The aim of this study was to elucidate the changes in oxidative stress and autonomic nervous activity in vertigo patients compared with healthy volunteers.Methods: Oxidative stress was assessed by evaluating biological antioxidant potential and reactive oxygen metabolites, and heart rate variability was measured to evaluate autonomic nervous activity. Thirty-four patients who complained of peripheral vertigo and were treated in our emergency department between January and August 2011 were enrolled in study 1. Oxidative stress and heart rate variability were measured and compared with those of healthy volunteers (n = 23). In study 2, oxidative stress in 18 vertigo patients and heart rate variability in 41 vertigo patients were measured between January and August 2012 before and after conventional treatment of vertigo to evaluate the effect of the treatment on oxidative stress and autonomic nervous activity.Results: Reactive oxygen metabolites were higher in vertigo patients than in healthy volunteers. Parasympathetic nervous activity was lower and the sympathetic/parasympathetic nervous activity ratio (autonomic nervous activity ratio) was higher in vertigo patients than in healthy volunteers. After treatment of vertigo, reactive oxygen metabolites decreased significantly and the autonomic nervous activity ratio became similar to that observed in healthy volunteers.Conclusions: Bedside monitoring of oxidative stress and heart rate variability may be useful for the diagnosis of vertigo and evaluation of the effect of treatment.

Seasonal differences in brown adipose tissue density and pulse rate variability in a thermoneutral environment

“…PRV was measured using a sphygmograph (TAS9 Pulse Analyzer Plus, YKC, Tokyo, Japan) for 15 min at 27 °C with subjects in the supine position and wearing light clothing. The frequency domain information was automatically analyzed with a fast Fourier transform [ 24 , 25 ]. This analysis involved 1000 samples, a 300-ms pulse interval resampling frequency, and a Hanning window function.…”

Melatonin Exerts Anti-Inflammatory, Antioxidant, and Neuromodulatory Effects That Could Potentially Be Useful in the Treatment of Vertigo

“…Vertigo patients show higher levels of reactive oxygen species (ROS) and superoxide metabolites than healthy subjects, as shown by multiple reports from subjects with different vestibular syndromes, such as BPPV, MD, or unspecified situations of chronic subjective vertigo. It includes higher levels of hydrogen peroxide, oxidation products of thiol and other ROS, and lower activity of superoxide dismutase (SOD), glutathione content, and catalase [17][18][19][20][21]. Oxidative stress may be due to the physiological stress that vertigo induces [18].…”

“…It includes higher levels of hydrogen peroxide, oxidation products of thiol and other ROS, and lower activity of superoxide dismutase (SOD), glutathione content, and catalase [17][18][19][20][21]. Oxidative stress may be due to the physiological stress that vertigo induces [18]. e antioxidant effect of melatonin is well known, since it acts as a direct scavenger of free radicals with the ability to detoxify both reactive oxygen and reactive nitrogen species [22].…”

Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study

“…Subjects who measured their PRV frequency by placing a sphygmograph (TAS9 Pulse Analyzer Plus; YKC, Tokyo, Japan) on their left index fingertip did so in the supine position for 15 min. The PRV frequency domain data were automatically analyzed using a fast Fourier transform [41,42]. This analysis involved 1000 samples, a 300-ms pulse-interval re-sampling frequency, and Hanning window function.…”