Melatonin Exerts Anti-Inflammatory, Antioxidant, and Neuromodulatory Effects That Could Potentially Be Useful in the Treatment of Vertigo

Abstract

The acute phase of vertigo involves multiple neurotransmitters, inflammatory mediators, and products of oxidative stress. The vestibular pathway has multiple melatonin receptors distributed along its path, both centrally and peripherally. In addition, melatonin has been shown to be a powerful antioxidant and anti-inflammatory agent against factors related to vertigo, such as Bax/caspases, interleukins, and chemokines. Likewise, it exerts central GABAergic, antidopaminergic, and anti-migraine functions and regulates sympathetic activity in a similar way to the drugs classically used in acute vestibular crisis. In this review, the role of melatonin as a potential treatment of the acute phase of vertigo is discussed.

Nanotechnology Frontiers in γ-Herpesviruses Treatments

“…This therapeutic displays anti-tumoral properties, regulating cell cycle progression, apoptosis, induced-oxidative stress, immune stimulation, and growth signaling, exerting anti-proliferative effects [ 80 , 81 ]. It was shown that melatonin represses the Warburg effect, ameliorates disturbed mitochondrial bioenergetics, and is a pro-oxidant in cancer cells, even in cancer stem cells (CSCs) [ 82 , 83 ].…”