Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Fuse, Sayuri; Endo, Tasuki; Tanaka, Reina; Kuroiwa, Miyuki; Ando, Akira; Kume, Ayami; Yamamoto, Akiko; Kuribayashi, Kanna; Somekawa, Shinji; Takeshita, Masamichi; Hashimoto, Masaki; Kime, Ryotaro; Kurosawa, Yuko; Hamaoka, Toshiyuki

doi:10.3390/nu12092676

Cited by 13 publications

(8 citation statements)

References 52 publications

(97 reference statements)

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“…Higher resting metabolic rate was reported after acute administration of capsaicin in 18 FDG-BAT–positive individuals ( 714 , 715 ). Six-week capsaicin supplementation in healthy individuals increased supraclavicular BAT 18 FDG uptake ( 716 ) and supraclavicular hemoglobin concentration assessed by near-infrared time-resolved spectroscopy ( 716 , 717 ), taken as a surrogate for BAT vascularization and thermogenic activity. In contrast, acute capsaicin administration did not increase BAT 18 FDG uptake even in healthy individuals displaying a cold-induced increase in BAT 18 FDG uptake ( 715 ).…”

Section: Pharmacological Activation Of Brown Adipose Tissuementioning

confidence: 99%

Brown Adipose Tissue—A Translational Perspective

et al. 2022

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Brown adipose tissue (BAT) displays the unique capacity to generate heat through uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for cardiometabolic diseases. Here, we review BAT cellular metabolism, its regulation by the central nervous and endocrine systems and circulating metabolites, the plausible roles of this tissue in human thermoregulation, energy balance and cardiometabolic disorders, and the current knowledge on its pharmacological stimulation in humans. The current definition and measurement of BAT in human studies relies almost exclusively on BAT glucose uptake from positron emission tomography (PET) with 18F-fluorodeoxiglucose ( 18FDG), which can be dissociated from BAT thermogenic activity, as for example in insulin resistant states. The most important energy substrate for BAT thermogenesis is its intracellular fatty acid content mobilized from sympathetic stimulation of intracellular triglyceride (TG) lipolysis. This lipolytic BAT response is intertwined with that of white adipose and other metabolic tissues, and cannot be independently stimulated with the drugs tested thus far. BAT is an interesting and biologically plausible target that has yet to be fully and selectively activated to increase the body’s thermogenic response and shift energy balance. The field of human BAT research is in need of methods able to directly, specifically and reliably measure BAT thermogenic capacity while also tracking the related thermogenic responses in white adipose and other tissues. Until this is achieved, uncertainty will remain about the role played by this fascinating tissue in human cardiometabolic diseases.

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Section: Pharmacological Activation Of Brown Adipose Tissuementioning

confidence: 99%

Brown Adipose Tissue—A Translational Perspective

et al. 2022

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“…Furthermore, dietary capsaicin induces browning of white adipose tissue by activating TRPV1 channels ( Baskaran et al, 2016 ; El Hadi et al, 2019 ). Prolonged ingestion of capsinoids for 6 weeks increases BAT vascular density and resting energy expenditure in healthy adults ( Fuse et al, 2020 ). Capsaicin and its analog capsinoids, are representative TRPV1 agonists, and as such decrease body fat through the activation and recruitment of BAT, mimicking the effects of cold induced thermogenesis ( Saito, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Both caffeine and Capsicum annuum fruit powder lower blood glucose levels and increase brown adipose tissue temperature in healthy adult males

et al. 2022

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Using a combination of respiratory gas exchange, infrared thermography, and blood glucose (BGL) analysis, we have investigated the impact of Capsicum annuum (C. annuum) fruit powder (475 mg) or caffeine (100 mg) on metabolic activity in a placebo controlled (lactose, 100 mg) double-blinded three-way cross-over-design experiment. Metabolic measurements were made on day 1 and day 7 of supplementation in eight adult male participants (22.2 ± 2 years of age, BMI 23 ± 2 kg/m2, x̅ ± SD). Participants arrived fasted overnight and were fed a high carbohydrate meal (90 g glucose), raising BGL from fasting baseline (4.4 ± 0.3 mmol/L) to peak BGL (8.5 ± 0.3 mmol/L) 45 min after the meal. Participants consumed the supplement 45 min after the meal, and both caffeine and C. annuum fruit powder restored BGL (F (8,178) = 2.2, p = 0.02) to near fasting levels within 15 min of supplementation compared to placebo (120 min). In parallel both supplements increased energy expenditure (F (2, 21) = 175.6, p < 0.001) over the 120-min test period (caffeine = 50.74 ± 2 kcal/kg/min, C. annuum fruit = 50.95 ± 1 kcal/kg/min, placebo = 29.34 ± 1 kcal/kg/min). Both caffeine and C. annuum fruit powder increased supraclavicular fossa temperature (F (2,42) = 32, p < 0.001) on both day 1 and day 7 of testing over the 120-min test period. No statistical difference in core temperature or reference point temperature, mean arterial pressure or heart rate was observed due to supplementation nor was any statistical difference seen between day 1 and day 7 of intervention. This is important for implementing dietary ingredients as potential metabolism increasing supplements. Together the results imply that through dietary supplements such as caffeine and C. annuum, mechanisms for increasing metabolism can be potentially targeted to improve metabolic homeostasis in people.

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“…In our study, we also confirmed a significant correlation between cold-induced thermogenesis, which is an indicator of BAT activity [ 18 ], and [total-Hb]sup. Furthermore, a longitudinal study found that [total-Hb]sup and 18 FDG-PET/CT parameters increased in parallel during chronic intake of thermogenic capsinoids, which are known to increase the mass and activity of BAT, and decreased after cessation of intake [ 40 , 41 ]. Therefore, we believe that [total-Hb]sup can be used to evaluate BAT-d under thermoneutral conditions.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans

Kuroiwa

Hamaoka-Fuse

Sugimoto

et al. 2021

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This study examined the relationship between plasma amino acid (AA) concentrations, including branched-chain AAs, and brown adipose tissue density (BAT-d). One hundred and seventy-three subjects (69 men, 104 women) aged 22–68 years were recruited during the winter season. AAs were comprehensively quantified using liquid chromatography-time-of-flight-mass spectrometry. The total hemoglobin concentration in the supraclavicular region ([total-Hb]sup), an indicator of BAT-d, was assessed using near-infrared time-resolved spectroscopy. Anthropometric parameters, including age, percentage of body fat, and visceral fat, were evaluated. Factors associated with higher (≥74 µM) or lower (<74 µM) [total-Hb]sup were investigated by multiple logistic regression models that included AA concentrations alone (model 1) or AA concentrations and anthropometric parameters (model 2) as independent variables. When adjusted for the false discovery rate, [total-Hb]sup was positively correlated with glycine and asparagine levels in men and with the serine level in both men and women and was negatively correlated with the branched-chain AA concentration in men. Models 1 and 2 correlated with higher or lower BAT-d for men (r = 0.73, p = 0.015) and women (r = 0.58, p = 0.079) and for men (r = 0.82, p = 0.0070) and women (r = 0.70, p = 0.020), respectively. A combination of anthropometric parameters and plasma AA concentrations could be a reliable biomarker for higher and lower BAT-d.

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Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Cited by 13 publications

References 52 publications

Brown Adipose Tissue—A Translational Perspective

Brown Adipose Tissue—A Translational Perspective

Both caffeine and Capsicum annuum fruit powder lower blood glucose levels and increase brown adipose tissue temperature in healthy adult males

Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans

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