Oxidative Injury and Inflammatory Periodontal Diseases : the Challenge of Anti-Oxidants to Free Radicals and Reactive Oxygen Species

Abstract

ABSTRACT. In recent years, there has been a tremendous expansion in medical and dental research concerned with free radicals, reactive oxygen species, and anti-oxidant defense mechanisms. This review is intended to provide a critical, up-to-date summary of the field, with particular emphasis on its implications for the application of "anti-oxidant therapy" in periodontal disease. We have reviewed the nomenclature, mechanisms of actions, features, and sources of most common free radicals and reactive oxygen species, as well as analyzed the typical biological targets for oxidative damage. Based on a review of direct and indirect anti-oxidant host defenses, particularly in relation to the key role of polymorphonuclear neutrophils in periodontitis, we review current evidence for oxidative damage in chronic inflammatory periodontal disease, and the possible therapeutic effects of anti-oxidants in treating and/or preventing such pathology, with special attention to vitamin E and Co-enzyme Q.

Effect of rich Selenium Mushroom Polysaccharides on Hyperlipidemia Metabolism and Lipoprotein Lipase Activity of Tests Mice

“…It comes down to the hyper -cholesterolemia perhaps raise the small pieces, polymorphic nuclear cells, white blood cells and endothelial cells cholesterol content [11]. Thus MDA production may initiate a series of reactions and increase the oil peroxide route [12]. Our results indicated that S-EF oral prevented perhaps that hypercholesterolemia may cause the elevation of MDA.…”

Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health

“…Battino et al, reviewed the role of CoQ10 as an important antioxidant in free radical mediated neurodegenerative diseases [8]. Littaru and Henson have demonstrated the deficiency of CoQ10 in the gingival tissues of periodontitis subjects [9,10].…”

The Effect Of İnitial Periodontal Therapy On Saliva And Plasma Total Antioxidant Capacity Of Non-Smoking Periodontitis Patients

“…11,12 Ancak araştırmacılar; TAOK seviyesindeki bu düşüşün meydana gelme sebebinin, AO'ların, kronik periodontitiste artış gösteren reaktif oksijen türevleri (ROT) tarafından kullanılması ve/veya AO sisteminde muhtemel bir sorun bulunmasından hangisi olabileceğinin henüz bilinmediğini ifade etmişlerdir. 13 TARTIŞMA Periodontal hastalıklarda düşük bulunan AO değerlerinin hastalığa sebebiyet veren yapısal bir durum veya hastalıkta artan ROT saldırısının sonucu meydana gelen fonksiyonel bir durum olup olmadığı henüz bilinmese de, periodontal tedavi ile azalmış TAOK seviyelerinin yükseltilebileceği görüşü önem kazanmıştır. 11,12 Periodontal tedavinin, generalize kronik periodontitisli bireylerdeki tükürük ve plazma TAOK üzerine etkisi değerlendirilen çalışmamızda, periodontal tedavi öncesi yapılan incelemelerde, plazma TAOK değerleri kontrol grubunda periodontitisli gruba göre anlamlı olmasa da yüksek bulunmuştur (p=0.07).…”