Oxidative cyanide-free cyanation on arylboronic acid derivatives using aryl/heteroaryl thiocyanate using novel IL-PdCl₄ catalyst under mild condition

Copper-catalyzed ortho-thiocyanation of aromatic amines

“…1). 11 Thiocyanate products are associated with their wide range of antifungal, antitumor, and antiparasitic activities. 12 Therefore, the synthesis of thiocyanate compounds is attractive to organic and medicinal chemistry researchers.…”

Microwave‐Assisted Metal‐Free C(sp2)−H Thiocyanation of Aromatic Amines

“…[2] The resulting thiocyanate group serves as a valuable intermediate due to its ease of conversion into various other sulfur functionalities. [3] Thiocyanates can be easily transformed into sulfides, [4] disulfides, [5] nitriles, [6] thionitrile, [7] thiophenols, [8] thioethers, [9] thioesters, [10] thiocarbamates, [11] sulfonyl cyanides, [12] methylthiolate, [13] phosphorothioate, [14] making them invaluable building blocks for many chemical transformations (Figure 1). This flexibility has allowed for the development of a wide variety of drug molecules, bioactive compounds as well as novel materials with intriguing properties.…”

A Direct Access to Thiocyano-Thioesters from Cyclic Thioacetals via Photoredox Catalysis: An Introduction of Two Functional groups in One-Pot

“…Organic thiocyanates are very important and useful synthetic intermediates for the synthesis of tetrazoles and different functionalities such as thiols, disulfides, thioethers, trifuloromethyl thioethers, thiocarbamates, thioesters, and sulfonyl cyanides. [1][2][3][4][5][6][7][8][9] Likewise, thioesters are also important synthetic intermediates in many bio-synthetic pathways such as native chemical ligation, protein synthesis and nucleic acid synthesis. 10 Also, thioesters have been utilized in the drug delivery applications, biomolecules labelling.…”