Overview of the Role of Vanillin on Redox Status and Cancer Development

Bezerra, Daniel P.; Soares, Anne Karine Nascimento; Sousa, Damião Pergentino de

doi:10.1155/2016/9734816

Cited by 86 publications

(61 citation statements)

References 65 publications

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“…It is widely used in processed foods, pharmaceutical products, and in perfume (Zamzuri & Abd-Aziz, 2013). Previous studies showed that vanillin has antioxidant, anti-inflammatory, anti-carcinogenic, and inhibition mutagenesis (Bezerra, Nascimento Soares, & de Sousa, 2016).…”

Section: Introductionmentioning

confidence: 99%

The protective effect of taurine and/or vanillin against renal, testicular, and hematological alterations induced by potassium bromate toxicity in rats

Mohamed

saddek

2019

JoBAZ

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Background: Potassium bromate (KBrO 3 ) causes toxicity in humans and experimental animals. The wide exposure to KBrO 3 in water disinfection and as a food additive necessitates finding of available antidotes for its hazards as taurine and/or vanillin. Aim: The present study was conducted to investigate the protective effects of taurine and/or vanillin against potassium bromate toxicity on renal, testicular, and hematological parameters in adult male albino rats. Methods: For this purpose, 30 rats were divided as follows: control group, rats were fed balanced diet and served as normal control; group 2, rats were fed balanced diet and served as positive control; group 3, rats were fed balanced diet supplemented with taurine (100 mg/kg diet); group4, rats were fed balanced diet supplemented with vanillin (100 mg/kg diet); and group5, rats were fed balanced diet supplemented with taurine and vanillin at the same tested dose for 3 weeks. Groups from 2 to 5 were orally administered a single dose of KBrO 3 (100 mg/kg diet) then sacrificed after 48 h. Results: Results showed that KBrO 3 administration induces testicular damage reflected in a significant decrease in total protein, glycogen, sialic acid with a significant increase in MDA level in testicular tissue. Also, there was a significant decrease in total spermatic count accompanied by an increase in the total number of malformed sperms (head, tail, and head and tail) in the pot bromate intoxicated group. Also, KBrO 3 toxicity induce renal damage manifested in a significant increase in serum urea, creatinine, uric acid, and xanthine oxidase activity. Renal TNF-α, IL-6, Hcy, and MDA significantly increased in the pot-bromate intoxicated group. Finally, hematological results showed a significant decrease in Hb%, MCV, RBCs, and WBCs count in the pot-bromate intoxicated group as compared to normal control groups. Histological findings showed that impaired renal and testicular histology was concomitant with biochemical parameters. Conclusion: Treatment with taurine and/or vanillin showed a significant ameliorative effect against deleterious effects of pot bromate toxicity on hematological parameters, renal and testicular tissues. Moreover, the recorded improvement of the studied parameters in rats pretreated with taurine and vanillin as antioxidants proves their synergistic effect.

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Section: Introductionmentioning

confidence: 99%

The protective effect of taurine and/or vanillin against renal, testicular, and hematological alterations induced by potassium bromate toxicity in rats

Mohamed

saddek

2019

JoBAZ

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“…High levels of capsaicin metabolites in urine following capsaicin consumption may be a sign of gastric tumor development as well. The risk for capsaicin-associated cancer is influenced by the expression of capsaicin metabolizing enzymes, such as 16-hydroxycapsaicin, 17-hydroxycapsaicin, and 16-, 17-dehydrocapsaicin, vanillylamine, and vanillin, which increase the risk for cancers [42][43][44]. As a result, we propose that capsaicin is a potential carcinogen.…”

Section: Capsaicin Dose In Mice Resembles Human Capsaicin Consumptionmentioning

confidence: 95%

Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively

Aziz

Xin

Gao

et al. 2020

Cancers

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Gastric cancer risk evolves over time due to environmental, dietary, and lifestyle changes, including Helicobacter pylori (H. pylori) infection and consumption of hot peppers (i.e., capsaicin). H. pylori infection promotes gastric mucosal injury in the early phase of capsaicin exposure. This relationship suggests a need to investigate the mechanism of how both H. pylori infection and capsaicin contribute to gastric inflammation and lead to gastric cancer. C57-Balb/c mice were infected with the H. pylori (SS1) strain and then fed capsaicin (0.05% or 0.2 g/kg/day) or not. Consequently, tumor size and phenotype were analyzed to determine the molecular mechanism driving the shift from gastritis to stomach cancer. Moreover, we used 2-difluoromethylornithine (DFMO) in mice to prevent gastric tumorigenesis by reducing inflammation and promoting recovery of disease-free stasis. This study provides evidence showing that a combination of H. pylori infection and capsaicin consumption leads to gastric carcinogenesis mediated through interleukin-6 (IL-6) stimulation with an incidence rate of 50%. The anti-inflammatory role of DFMO highlights the injurious effect of inflammation in gastric cancer development and the need to reduce gastric inflammation for cancer prevention by inhibiting IL-6. Accordingly, preventive measures such as reduced capsaicin consumption, H. pylori clearance, and DFMO treatment may lessen gastric cancer incidence.

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“…Vanillin, a 4-hydroxy-3-methoxybenzaldehyde isolated from the seed of Vanilla planifolia, is widely used as a flavoring agent in food and cosmetics (117). Vanillin inhibited cell migration, lamellipodia formation and angiogenesis and induced apoptosis in many cancer types including lung cancer (117)(118)(119)(120).…”

Section: Natural Product Targeting Lung Cancer Stem Cellsmentioning

confidence: 99%

Lung Cancer Stem Cells and Cancer Stem Cell-targeting Natural Compounds

2018

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The novel information regarding molecular and translational research have created a paradigm shift in the understanding of lung cancer biology, revealing the more precise target for anti-cancer drug discovery. Lung cancer is a leading cause of cancer death worldwide accounting for approximately 1 in 5 of all cancer-related deaths. The most important causes of death in such a cancer involves the treatment failure as well as the spreading of cancer cells to distant sites which the cancer stem cell (CSC) within the tumor is accepted as a key driver. CSC is a rare special population of cancer cells exhibiting high tumorigenic properties together with self-renewal and differentiation capability. CSC is not only linked with high tumor-initiating activity, but is also implicated in chemotherapeutic resistance, metastasis, epithelial to mesenchymal transition, and recurrence. Thereafter, novel therapeutic strategies targeting these CSCs are considered in order to improve long-term clinical outcome. Here, we provide sufficient data regarding the biology of CSC in lung cancer, known CSC markers and cellular signals, and promising compounds targeting the stem cell signals in lung cancer that may benefit the development of novel anti-cancer treatment.

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Overview of the Role of Vanillin on Redox Status and Cancer Development

Cited by 86 publications

References 65 publications

The protective effect of taurine and/or vanillin against renal, testicular, and hematological alterations induced by potassium bromate toxicity in rats

The protective effect of taurine and/or vanillin against renal, testicular, and hematological alterations induced by potassium bromate toxicity in rats

Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively

Lung Cancer Stem Cells and Cancer Stem Cell-targeting Natural Compounds

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