Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively

Aziz, Faisal; Xin, Mingxia; Gao, Yunfeng; Chakroborty, Abhijit; Khan, Imran; Monts, Josh; Monson, Kjersten; Bode, Ann M.; Dong, Zigang

doi:10.3390/cancers12040816

Cited by 24 publications

(15 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The indications for H. pylori eradication and endoscopic examination are diverse due to the geographic differences in the availability of medications and endoscopy, the prevalence of gastric cancer, and the health insurance systems involved. H. pylori is one of the significant contributors of gastritis leading to gastric cancer, especially combined with chronic alcohol consumption and the usage of capsaicin [14,15]. In Taiwan, our national health insurance (NHI) system provides entire coverage for medications used to eradicate H. pylori and endoscopy for pretreatment screening and posttreatment surveillance due to the high prevalence of H. pylori infection and gastric cancer [16,17].…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

Liu

Lin

et al. 2022

Microorganisms

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) can be eradicated immediately while conducting an endoscopic examination. The eradication rate of intraluminal therapy for H. pylori infection (ILTHPI) is 53.7% (51/95) via local application of single-dose medicament containing amoxicillin, metronidazole, and clarithromycin. We aimed to evaluate factors affecting ILTHPI and to assess the efficacy among single antibiotics, and compared our results with combined antibiotics. We enrolled H. pylori-infected treatment-naïve symptomatic patients; 95 completed triple-antibiotic ILTHPI were evaluated for risk factors, along with 60 completed mono-antibiotic ILTHPI containing amoxicillin, clarithromycin, or metronidazole in each of the 20 patients. Univariate analysis revealed the significant influence of BMI (OR: 1.15; 95% CI: 1.03–1.27, p = 0.011) and gastric juice pH (OR: 1.35; 95% CI: 1.16–1.58, p = 0.0001). Logistic regression analysis also showed significant influence of gastric juice pH (OR: 1.30; 95% CI: 1.10–1.54, p = 0.002). The eradication rate of mono-antibiotic ILTHPI is significantly lower than triple-antibiotic ILTHPI (11.7% vs. 53.7%; p < 0.0001; α = 0.05, power = 1.0). The efficacy was 20% (4/20) for metronidazole, 10% (2/20) for amoxicillin, and 5% (1/20) for clarithromycin. In conclusion, the level of gastric juice pH is a crucial factor affecting the ILTHPI. The detection of gastric juice pH and selection of optimal intraluminal medicaments are important. Further studies with combined antibiotics for ILTHPI, perhaps metronidazole-containing medicaments, are recommended.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

Liu

Lin

et al. 2022

Microorganisms

View full text Add to dashboard Cite

show abstract

“…It is of great interest to know the specific effect of this compound on carcinomas of the upper aerodigestive tract. Previous studies ( 37 - 38 ) have proven that capsaicin supresses the growth of gastric cancer through downregulation of several pathways (NADPH, ERK 1/2, p38 MAPK, JNK), inhibition of inflammatory molecules (IL-6) and increase of apoptotic molecules (caspase-3, p53). On the other hand, capsaicin also induces G1 arrest and apoptosis of nasopharyngeal cancer cells through mitochondrial depolarization and acting on specific pathways (PI3K/mTOR) and molecules (caspase-3, Bcl-2) ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Capsaicin intake and oral carcinogenesis: A systematic review

Mosqueda-Solís

Mendoza²,

Aguirre‐Urízar³

et al. 2021

Med Oral

View full text Add to dashboard Cite

Background Chili is the most heavily and frequently consumed spice, either as a flavouring or colouring agent, and it is also a major source of pro-vitamin A, vitamin E and C. The main capsinoidcapsaicinoid found in chili peppers is capsaicin. It has been demonstrated that capsaicin acts as a cancer-suppressing agent through its antioxidant and anti-inflammatory effects, by blocking several signal transduction pathways. Oral squamous cell carcinoma is one of the most prevalent cancer worldwide. It is noteworthy that in countries where populations of diverse ethnic groups co-exist, differences have been observed in terms of incidence of oral cancer. The variances in their diet could explain, at least in part, these differences. The objective of this systematic review is to explore if there is evidence of a possible relationship between capsaicin intake and the incidence of oral squamous cell carcinoma, and discuss such association. Material and Methods A bibliographical search was made in PubMed, Scopus and Web of Science databases, and finally 7 experimental studies were included; OHAT risk of bias tool was used to assess their quality. Results allAll the studies confirm that capsaicin is a chemopreventive agent that prevents the development of oral cancer, through inhibition of malignant cell proliferation and increase of apoptosis. Conclusions More human studies are needed in order to clarify the real link between consumption of chili (capsaicin) and the prevalence of oral cancer. Key words: Chili, capsaicin, oral epithelial dysplasia, oral cancer, cell proliferation, apoptosis.

show abstract

“…Gastric cancer is a multifactorial disease with a complex interplay between genetics, lifestyle, and environment [ 28 , 29 , 30 , 31 ]. Helicobacter pylori infection is the most common chronic bacterial infection and affects over 50% of the world’s population.…”

Section: Mir-223 and Cancermentioning

confidence: 99%

Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer

Aziz

Chakraborty

Khan

et al. 2022

Biology

Self Cite

View full text Add to dashboard Cite

In 1993, the discovery of microRNAs in Caenorhabditis elegans (C. elegans) altered the paradigmatic view of RNA biology and post-transcriptional gene regulation. Further study revealed the role of microRNAs in disease development and progression. In particular, this review highlights microRNA-223 (miR-223 or miRNA-223) expression in malignant neoplastic disorders. miR-223 expression controls aspects of hematopoiesis and apoptosis, and cell proliferation, migration, and invasion. miR-223 regulates a number of gene targets, including cytoplasmic activation/proliferation-associated protein-1 (Caprin-1), insulin-like growth factor-1 receptor (IGF-1R), and other cell proliferation- and cell cycle-associated genes. Several studies have proposed miR-223 as a novel biomarker for early cancer diagnosis. Here, we emphasize miR-223′s role in the development and progression of cancer.

show abstract

Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively

Cited by 24 publications

References 41 publications

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

Capsaicin intake and oral carcinogenesis: A systematic review

Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer

Contact Info

Product

Resources

About