Outcome of treatment of venous stasis ulcers

Monk, Barry; Sárkány, I.

doi:10.1111/j.1365-2230.1982.tb02447.x

Cited by 83 publications

(23 citation statements)

References 3 publications

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“…There is a probable underestimation of the true extent of venous leg ulceration in the general population due to its underreporting [7]. Venous ulcers are characterised by a recurring pattern of healing and subsequent 70% recurrence rate at one year [9][10][11][12][13][14]. Venous ulceration places a huge monetary burden on the healthcare system [15].…”

Section: Introductionmentioning

confidence: 99%

Topical Wound Oxygen Versus Conventional Compression Dressings in the Management of Refractory Venous Ulcers

Sultan¹,

Tawfick²,

Kavanagh³

et al. 2016

Wound Healing - New Insights Into Ancient Challenges

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Topical wound oxygen (TWO 2 ) proposes an innovative therapy option in the management of refractory non-healing venous ulcers (RVU) that aims to accelerate wound healing. TWO 2 accelerates epithelialisation. This leads to the development of a higher tensile strength collagen, which lessens scarring and the risk of recurrence. Sixty-seven limbs with 67 ulcers were managed using TWO 2 therapy, and 65 limbs with 65 ulcers were managed using conventional compression dressings (CCD). The proportion of ulcers completely healed by 12 weeks was 76% in patients managed with TWO 2 , compared to 46% in patients managed with CCD (p < 0.0001). The mean reduction in ulcer surface area at 12 weeks was 96% in the TWO 2 therapy group, compared to 61% in patients managed with CCD. The median time to full ulcer healing was 57 days in the TWO 2 group, in contrast to 107 days in patients managed with CCD (p < 0.0001). TWO 2 patients had a significantly improved Quality-Adjusted Time Spent Without Symptoms of disease and Toxicity of treatment (Q-TWiST) compared to CCD patients, denoting an improved outcome (p < 0.0001). TWO 2 reduces the time needed for RVU healing and is successful in pain alleviation and MRSA elimination. TWO 2 therapy radically degrades recurrence rates. Utilising diffused oxygen raises the capillary partial pressure of oxygen (Po 2 ) levels at the wound site, stimulating epithelialisation, and granulation of new healthy tissue. Taking the social and individual aspects of chronic venous ulceration into account, the use of TWO 2 can provide an overwhelmingly improved quality of life for long-time sufferers of this debilitating disease.

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Section: Introductionmentioning

confidence: 99%

Topical Wound Oxygen Versus Conventional Compression Dressings in the Management of Refractory Venous Ulcers

Sultan¹,

Tawfick²,

Kavanagh³

et al. 2016

Wound Healing - New Insights Into Ancient Challenges

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“…These figures compare favorably with other treatment modalities for venous ulcers. Monk and Sarkany found that two‐thirds of venous ulcers that healed during hospitalization had reulcerated within the following year 15 . The use of pinch grafting did not improve the patient's prognosis.…”

Section: Discussionmentioning

confidence: 99%

Cultured Allogenic Keratinocyte Grafts in the Management of Wound Healing: Prognostic Factors

Phillips

Gilchrest

1989

The Journal of Dermatologic Surgery and Oncology

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Cultured allografts derived from neonatal foreskin provide a potent stimulus to wound healing in a wide variety of wounds. Their application is a simple outpatient procedure involving no discomfort for the patient. In contrast to autografting, no biopsy is necessary, and growth of newborn keratinocytes in cultures is more rapid than that of adult cells. Use of cultured allogeneic cells offers immediate graft availability and the possibility of stockpiling and preserving the graft for future use. Cultured epidermal allografts may be valuable in accelerating healing by second intention in surgical wounds, as well as being a helpful addition to chronic ulcer management. In venous disease, the outcome is at least comparable to other forms of skin grafting. Ulcers due to connective tissue disorders fared less well and deep chronic ulcers (down to fascia or tendon) were not significantly improved by cultured allograft application. Surprisingly, patient age did not influence outcome.

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“…7 More severe complications include cellulitis, osteomyelitis and malignant change 89 High rates of relapse after healing is other problem with annual recurrence rates varying between 26% and 69% 10–12. In addition, VU comes with physical, social, economic and emotional burden 13…”

Section: Introductionmentioning

confidence: 99%

Framing of research question using the PICOT format in randomised controlled trials of venous ulcer disease: a protocol for a systematic survey of the literature

et al. 2016

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IntroductionAlthough venous ulcers have a great social and economic impact, there is a lack of evidence from randomised controlled trials (RCTs) to support appropriate management for this disease. Framing the research question using the Population; Intervention; Comparator; Outcome; Time frame (PICOT) format in RCTs can improve the quality of the research design.ObjectivesTo evaluate how the PICOT format is used to frame a research question in reports of RCTs of venous ulcer disease and to determine the factors associated with better adherence to the PICOT format in framing the research question.Methods and analysesWe will conduct a systematic survey of RCTs on venous ulcers published in the National Institute of Health, PubMed database between January 2009 and May 2016. We will include all RCTs addressing therapeutic intervention for venous ulcer disease involving human subjects, and published in the English language. The selection process will be carried out in duplicate by two independent investigators. First, titles and abstracts will be screened, then full-text articles. We will examine whether the five elements of the PICOT format are used in formulating the research question and give a score between 0 and 5. The primary outcome will be the proportion of studies that have adequately reported all five PICOT elements.DisseminationThis will be the first survey to assess how the PICOT format is used to frame research questions on the management of venous ulcers in reports of RCTs. On completion, this review will be submitted to a peer-reviewed biomedical journal for publication and the findings will also be presented at scientific conferences.

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Outcome of treatment of venous stasis ulcers

Cited by 83 publications

References 3 publications

Topical Wound Oxygen Versus Conventional Compression Dressings in the Management of Refractory Venous Ulcers

Topical Wound Oxygen Versus Conventional Compression Dressings in the Management of Refractory Venous Ulcers

Cultured Allogenic Keratinocyte Grafts in the Management of Wound Healing: Prognostic Factors

Framing of research question using the PICOT format in randomised controlled trials of venous ulcer disease: a protocol for a systematic survey of the literature

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